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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Plant Development and Abiotic Stress Response Regulation via Alternative Splicing

edited by

Yong-Hwan Moon

submission deadline 20 May 2025 | 2 articles | Viewed by 2636 | Submission Open

Keywords: plants; development; abiotic stress responses; alternative splicing; transcriptional regulation; signaling; splicing factors

(This special issue belongs to the Section Molecular Plant Sciences)

Pathophysiology and Treatment of Alzheimer's Disease

edited by

Jeffrey Fessel

submission deadline 20 May 2025 | 1 articles | Viewed by 2538 | Submission Open

Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Editorial Board Members’ Collection Series: “Emerging Progress in Nanomedicine”

edited by Hamed Laroui and

Federico D’Agata

submission deadline 20 May 2025 | 1 articles | Viewed by 2506 | Submission Open

Keywords: nanomedicine; nanoparticles; nanotechnology; targeted drug delivery; pharmaceutical nanoimaging; nanoengineering; nanotoxicology

(This special issue belongs to the Section Molecular Nanoscience)

New Molecular Mechanisms and Markers in Inflammatory Disorders, 3rd Edition

edited by

Elena Vianello

submission deadline 20 May 2025 | 4 articles | Viewed by 2489 | Submission Open

Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling

(This special issue belongs to the Section Molecular Immunology)

Advances in Research on Antifungal Resistance

edited by Anna Tomova

submission deadline 20 May 2025 | 3 articles | Viewed by 2479 | Submission Open

Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Plant–Microbe Interactions

edited by

Yangyong Zhang

submission deadline 20 May 2025 | 2 articles | Viewed by 2442 | Submission Open

Keywords: plant– microbe interaction; plant immunity; metabolism; omics; single-cell sequencing; climate change; synthetic biology; engineered plants and microbes

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring the Cytoskeleton and Its Regulators: From Structure to Function

edited by

Wan Lee

submission deadline 20 May 2025 | 2 articles | Viewed by 2329 | Submission Open

Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology

(This special issue belongs to the Section Molecular Biology)

Periodontal Disease: From Pathogenesis, Diagnosis to Treatment

edited by Sasanka Chukkapalli

submission deadline 20 May 2025 | 2 articles | Viewed by 2321 | Submission Open

Keywords: periodontal disease; oral pathogens; dysbiosis in the oral cavity; new avenues for periodontal disease diagnosis; periodontal medicine; periodontal disease therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthetic and Natural Drugs for Pain Treatment

edited by Sara Ilari

submission deadline 20 May 2025 | 1 articles | Viewed by 2301 | Submission Open

Keywords: oxidative stress; natural drugs; synthetic drugs; pain; biomarkers; mitochondria

(This special issue belongs to the Section Molecular Pharmacology)

Immunity, Inflammation, and Injury in the Pathogenesis and Progression of Kidney Diseases—from Bench to Bedside

edited by

Kinga Musiał

and

Katarzyna Taranta-Janusz

submission deadline 20 May 2025 | 1 articles | Viewed by 2275 | Submission Open

Keywords: systemic immune inflammation index; neutrophil extracellular traps; pathogen associated molecular patterns; damage associated molecular patterns; complement system; stress proteins; acute kidney injury; tubular damage; chronic kidney disease; hypertension; glomerulopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Growth Hormone Tumor: Molecular Pathologies, Diagnosis, and Therapeutic Strategies

edited by

Sabrina Chiloiro

submission deadline 20 May 2025 | 1 articles | Viewed by 2250 | Submission Open

Keywords: acromegaly; growth hormone-secreting tumors; pituitary tumors; molecular targets; target therapy

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms of Intervertebral Disc Disease

edited by

Hosni Cherif

submission deadline 20 May 2025 | 1 articles | Viewed by 2233 | Submission Open

Keywords: intervertebral disc; disc degeneration; low back pain; disc aging; disc herniation; disc regeneration; inflammation; extracellular matrix; collagen; proteoglycans; matrix metalloproteinases (MMPs); senescence; quiescence; apoptosis; oxidative stress; senotherapeutics; cytokines; growth factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Respiratory Virus Infection

edited by Nikolaos Siafakas

submission deadline 20 May 2025 | 3 articles | Viewed by 2211 | Submission Open

Keywords: respiratory virus; diagnosis; surveillance; epidemiology; therapy; vaccination; influenza virus; coronavirus; respiratory syncytial virus; rhinovirus/enterovirus

(This special issue belongs to the Section Molecular Microbiology)

Beyond Silos: A Comprehensive Understanding of HIV Functional Cure and NeuroHIV

edited by Taisuke Izumi,

Alexander Zestos

and Anthony L. Riley

submission deadline 20 May 2025 | 1 articles | Viewed by 2204 | Submission Open

Keywords: neuroHIV; functional cure; antiretroviral therapy; reservoir; long-acting antivirals; chronic infection; host– virus interactions; immunotherapy; persistence; remission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Deciphering Molecular Complexity of Pancreatic Cancer

edited by

Dimitrios H. Roukos

submission deadline 20 May 2025 | 2 articles | Viewed by 2163 | Submission Open

Keywords: pancreatic cancer; intratumor heterogeneity; bulk and single-cell multiomics; tumor microenvironment; cancer immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 May 2025 | 1 articles | Viewed by 2159 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Metabolomics in the Field of Autoimmune Diseases

edited by

Cristina Piras

and

Federica Murgia

submission deadline 20 May 2025 | 1 articles | Viewed by 2154 | Submission Open

Keywords: metabolomics; proteomics; genomics; transcriptomics; biomarkers; autoimmune diseases; inflammatory diseases; nuclear magnetic resonance spectroscopy; mass spectrometry; precision medicine

(This special issue belongs to the Section Molecular Immunology)

Molecular Perspectives in the Diagnosis, Prevention, Treatment, and Vaccination Against Parasitic Diseases

edited by

Bartłomiej Tomasz Ferra

and Anna Lass

submission deadline 20 May 2025 | 2 articles | Viewed by 2139 | Submission Open

Keywords: parasitoses; vaccines; diagnostic; epidemiology; prevention; antibodies; cytokines; immune system; treatment; native antigen; recombinant protein; chimeric recombinant protein; multiepitope recombinant protein; pharmaceutical analogues; PCR; molecular techniques

(This special issue belongs to the Section Molecular Microbiology)

Obesity and Malignancies in Women: Searching for New Molecular Links

edited by

Luca Gelsomino

submission deadline 20 May 2025 | 1 articles | Viewed by 2117 | Submission Open

Keywords: obesity; female malignancies; adipokines; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Derived Natural Substances as Multi-target Therapeutic Modalities in Experimental Models of Non-communicable Diseases

edited by

Rumyana Simeonova

submission deadline 20 May 2025 | 2 articles | Viewed by 2106 | Submission Open

Keywords: cytokinins; phenolic acids; flavonoids; alkaloids; terpenoids; phenylpropanoids; natural products; toxicological characteristics; metabolomics and proteomics

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Acquiring Resistance to Treatments in Prostate Cancer: Perspectives of Old and New Organelles

edited by

Masatoshi Watanabe

submission deadline 20 May 2025 | 1 articles | Viewed by 2083 | Submission Open

Keywords: prostate cancer; castration-resistance; organelle; endoplasmic reticulum stress; mitochondria; Golgi apparatus; primary cilia; chemotherapy; radiation therapy; immunotherapy; PARP inhibitor; chemoresistance; radio-resistance; treatment-related neuroendocrine prostate cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genome Structure, Function and Dynamic Regulation of Cell Fate

edited by Georg Hildenbrand and

Michael Hausmann

submission deadline 20 May 2025 | 1 articles | Viewed by 2080 | Submission Open

Keywords: genome structure and organization; DNA sequence patterning and functional genomics; epigenetic regulation and chromatin remodeling; DNA damage response and cellular developments; cellular differentiation and cell fate; transcriptional control; chromatin architecture

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Perspectives on Virus–Host Interactions

edited by

Qibin Geng

submission deadline 20 May 2025 | 2 articles | Viewed by 2012 | Submission Open

Keywords: viral manipulation of host metabolics; virus– host interactions; host– pathogen co-evolution; susceptibility and resistance to viral infection; novel antiviral strategies

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanism and Pathogenesis of Cardiac Disease

edited by Yu-Hsun Kao

submission deadline 20 May 2025 | 2 articles | Viewed by 2004 | Submission Open

Keywords: cardiac diseases; cardiac metabolidm; epigenetics; ER stress; mitochondrial dysfunction; molecular mechanisms; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Dysregulation in Cardiovascular Conditions

edited by

Sergey Dikalov

submission deadline 20 May 2025 | 1 articles | Viewed by 1969 | Submission Open

Keywords: cardiovascular diseases; metabolic conditions; hypertension; heart failure; mitochondria; oxidative stress; vascular dysfunction; superoxide dismutase

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Reproductive Toxicity

edited by

Palma Simoniello

and

Luigi Rosati

submission deadline 20 May 2025 | 1 articles | Viewed by 1922 | Submission Open

Keywords: cytotoxicity; environmental stressors; gametogenesis; thermal stress; apoptosis; embryos; developmental gene regulation; endocrine disruption; gene expression; larval development; reproductive toxicology; teratogenesis; xenobiotics; heavy metals

(This special issue belongs to the Section Molecular Toxicology)

Therapeutic Target in Cardiovascular Disease

edited by Hyelim Park

submission deadline 20 May 2025 | 1 articles | Viewed by 1916 | Submission Open

Keywords: cardiac disease; arrhythmia; cardiac remodeling; therapeutic target

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Clostridial and Related Neurotoxins, 3rd Edition

edited by

Sabine Pellett

submission deadline 20 May 2025 | 1 articles | Viewed by 1903 | Submission Open

Keywords: botulinum neurotoxin; BoNT; toxicity; molecular mechanisms; recombinant; derivative; clostridium botulinum

(This special issue belongs to the Section Molecular Toxicology)

Neurodegenerative Disease: Looking for Oxidative Stress and Inflammation Mechanisms

edited by

Soraya L. Valles

submission deadline 20 May 2025 | 1 articles | Viewed by 1901 | Submission Open

Keywords: neurodegenerative disease; oxidative stress; inflammation mechanisms; neurons; astrocytes; microglia; oligodendroglia

(This special issue belongs to the Section Molecular Neurobiology)

Research on Cyclodextrin

edited by Valentina Giglio

submission deadline 20 May 2025 | 1 articles | Viewed by 1884 | Submission Open

Keywords: drug delivery systems; polymeric cyclodextrin; pollution removal; sponge-like material; selective targeting systems; catalyst

(This special issue belongs to the Section Materials Science)

Bioactive Peptides: Synthesis, Functions, and Medicinal Chemistry Applications

edited by

Giovanni Grazioso

submission deadline 20 May 2025 | 3 articles | Viewed by 1874 | Submission Open

Keywords: peptides; protein– protein interactions (PPIs); peptide intracellular delivery

(This special issue belongs to the Section Molecular Pharmacology)

The Molecular and Cellular Aspects of Insulin Resistance

edited by

Jesús Alberto Olivares-Reyes

and

Angélica Rueda

submission deadline 20 May 2025 | 1 articles | Viewed by 1855 | Submission Open

Keywords: insulin resistance; insulin receptor; IRS; Akt; PI3K; protein phosphorylation; protein dephosphorylation; inflammation; metabolic syndrome; cardiometabolic syndrome; diabetic cardiomyopathy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

B Cell Lymphoma: From Pathogenesis to Treatment

edited by

Myrna Gloria Candelaria

submission deadline 20 May 2025 | 1 articles | Viewed by 1840 | Submission Open

Keywords: non-Hodgkin lymphoma pathogenesis; B cell lymphoma regulation; epigenetics and B cell lymphoma; bispecific antibodies in lymphoma; epigenetics in B cell lymphoma

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology of Sulfatase

edited by

Joanne Tobacman

submission deadline 20 May 2025 | 1 articles | Viewed by 1817 | Submission Open

Keywords: chondroitin sulfatases; sulfotransferases; steroid; tyrosine; and other sulfatases; metabolic pathways affected by sulfation; impact of changes in sulfation on disease

(This special issue belongs to the Section Molecular Biology)

Synthesis of Advanced Polymer Materials, 3rd Edition

edited by

Haiyang Gao

submission deadline 20 May 2025 | 1 articles | Viewed by 1814 | Submission Open

Keywords: polymer synthesis; polymer chemistry; coordination polymerization; organometallic catalysts; polyolefin; degradable polymer materials; green and sustainable polymeric materials; homogeneous polymerization; heterogeneous polymerization

(This special issue belongs to the Section Macromolecules)

Physiological and Molecular Responses to Biotic and Abiotic Stressors in Marine Organisms

edited by

Chiara Lauritano

and Miriam Ruocco

submission deadline 20 May 2025 | 2 articles | Viewed by 1806 | Submission Open

Keywords: stress responses; marine organisms; enzymatic pathways; multiple stressors; stress markers; epigenetic response; physiological response

(This special issue belongs to the Section Molecular Biology)

New Advances in Bioactive Compounds in Health and Disease

edited by

Luís Silva

submission deadline 20 May 2025 | 2 articles | Viewed by 1787 | Submission Open

Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Lipid Metabolism and Biomarkers in Neural and Cardiometabolic Health

edited by

Elena Vianello

submission deadline 20 May 2025 | 1 articles | Viewed by 1768 | Submission Open

Keywords: lipid species; cardiovascular health; neural health; inflammation; cardiac biomarkers; neural biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Formation, Regulation and Affecting Factors of Fruit Quality, 2nd Edition

edited by

Wensuo Jia

submission deadline 20 May 2025 | 1 articles | Viewed by 1753 | Submission Open

Keywords: fruit ripening; fruit quality formation; signal transduction; hormones; environmental signals; transcription factors; key enzymes; metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

G Protein-Coupled Receptors in Cell Signaling Transductions—2nd Edition

edited by

Sandra Beer-Hammer

and

Ines Liebscher

submission deadline 20 May 2025 | 1 articles | Viewed by 1737 | Submission Open

Keywords: GPCRs; G-Proteins; canonical/non-canonical signaling; AGS proteins; RGS proteins; β -arrestin; NDPKs; pharmacological intervention; biased ligands

(This special issue belongs to the Section Biochemistry)

Design, Synthesis and Biological Activity Evaluation of Kinase Inhibitors

edited by Souvik Banerjee

submission deadline 20 May 2025 | 1 articles | Viewed by 1733 | Submission Open

Keywords: kinase inhibitors; dual inhibitors; adjuvant therapy; metabolic stability; drug resistance

(This special issue belongs to the Section Biochemistry)

Research on Drug Metabolism and Disposition

edited by Tashinga E. Bapiro

submission deadline 20 May 2025 | 1 articles | Viewed by 1733 | Submission Open

Keywords: drug metabolism; metabolite identification; biotransformation; clearance; bioavailability; pharmacokinetics; absorption; dose prediction; reaction phenotyping

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Veterinary Science

edited by

JeongWoo Kang

submission deadline 20 May 2025 | 1 articles | Viewed by 1708 | Submission Open

Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics

(This special issue belongs to the Section Molecular Toxicology)

Genomic Variation and Epidemiology of Cystic Fibrosis

edited by

Fernando Augusto Lima Marson

submission deadline 20 May 2025 | 1 articles | Viewed by 1703 | Submission Open

Keywords: CFTR; epidemiology; genetics; gene expression; personalized medicine; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Immunologic Perspectives on Mycobacterium tuberculosis Infection

edited by

Vishwanath Venketaraman

submission deadline 20 May 2025 | 1 articles | Viewed by 1700 | Submission Open

Keywords: M. tb infection; molecular immunology; HIV; AIDS; pathogenesis; host immune responses; adjunctive therapy; immune-enhancing agents; antimycobacterial compounds; host-directed therapies; pathogenesis; modulation of host immune responses

(This special issue belongs to the Section Molecular Immunology)

Diagnosis and Treatment of Osteoporosis

edited by

Fabio Vescini

submission deadline 20 May 2025 | 2 articles | Viewed by 1675 | Submission Open

Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Antonio Barbato

submission deadline 20 May 2025 | 1 articles | Viewed by 1662 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Biomarkers in Ischemic Stroke

edited by Hanna Pawluk and

Renata Kołodziejska

submission deadline 20 May 2025 | 2 articles | Viewed by 1608 | Submission Open

Keywords: stroke; brain tissue damage; ischemic stroke; inflammatory markers; immune response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism Involved in Cancer Metastasis

edited by

Mohamed Jemaà

submission deadline 20 May 2025 | 1 articles | Viewed by 1599 | Submission Open

Keywords: cell motility; cell migration; spheroid; metastasis; extracellular matrix; cell architecture; lamellipodia; epithelial-mesenchymal transition EMT; videomicroscopy; confocal microscopy; animal model

(This special issue belongs to the Section Molecular Oncology)

The Role of Extracellular Vesicles in Cancers

edited by