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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Studies of Immune-Related Diseases
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 6394 | Submission Open
Keywords: autoimmune diseases; inflammatory diseases; asthma and allergies; GWAS studies; GWAS meta-analysis; eQTLs and pQTLs analysis; endophenotypes; immune cell traits; single cell transcriptomics; functional genomics; fine mapping; casual variant; drug target
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Research and Treatment of Breast Cancer: 3rd Edition
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 6322 | Submission Open
Keywords: biomarkers; breast cancer; cancer stem cells; cell signaling; circulating tumor cells; drug discovery; molecular diagnostics; molecular profiling; targeted therapy; therapy resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Signaling Pathways in Neurodegenerative Disorders
edited by
submission deadline 20 May 2025 | 2 articles | Viewed by 6318 | Submission Open
Keywords: Alzheimer's and Huntington's disease; human neurodegenerative diseases; gamma-aminobutyric acid (GABA) and glutamate signalling; estrogen signalling; neurotrophin signalling
(This special issue belongs to the Section Molecular Neurobiology)
Emerging Molecular Views in Neuroendocrinology
edited by Katalin Köves
submission deadline 20 May 2025 | 4 articles | Viewed by 6314 | Submission Open
Keywords: neuropeptides; neurotransmitters; neural control of ovulation; molecular basis of neuroendocrine diseases; theranostics
(This special issue belongs to the Section Molecular Neurobiology)
Primary and Secondary Bladder Disorders in Neurourology and Inflammatory Diseases submission deadline 20 May 2025 | 4 articles | Viewed by 6025 | Submission Open
Keywords: bladder ischemia; bladder pain syndrome; interstitial cystitis; irradiation cystitis; ketamine cystitis; microbiota; overactive bladder; underactive bladder; botulinum toxin for bladder disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Strategies of Inflammatory Pain
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 5913 | Submission Open
Keywords: inflammation; inflammatory pain; molecular mechanism; central sensitization
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Evolving Ribosome Concept
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 5762 | Submission Open
Keywords: specialised ribosomes; ribosome heterogeneity; differential rRNA modification; ribosomal protein paralog genes; variation ribosome composition
(This special issue belongs to the Section Molecular Genetics and Genomics)
High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 5734 | Submission Open
Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight
(This special issue belongs to the Section Biochemistry)
Modulation of Transcription: Imag(in)ing a Fundamental Mechanism
edited by
submission deadline 20 May 2025 | 2 articles | Viewed by 5671 | Submission Open
(This special issue belongs to the Section Molecular Genetics and Genomics)
Medicinal Plants and Bioactive Compounds in Health and Disease submission deadline 20 May 2025 | 7 articles | Viewed by 5563 | Submission Open
Keywords: obesity; diabetes; metabolic syndrome; metabolic-associated fat liver disease; inflammatory processes; free radicals and oxidative stress; phyto-compounds; medicinal plants; nutrition; physical exercises
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Fascial Anatomy and Histology: Advances in Molecular Biology
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 5536 | Submission Open
Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnostics and Treatment of Inflammatory Bowel Disease submission deadline 20 May 2025 | 3 articles | Viewed by 5530 | Submission Open
Keywords: IBD molecular pathogenesis; intestinal mucosal healing; gut microbiota in IBD; fecal microbiota transplantation; target therapy in IBD; stem cell therapy; biologic agents; small molecules; adhesion antagonists; inflammatory cytokines; lymphocyte control
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Progression of Genetics in Breeding of Farm Animals
edited by
submission deadline 20 May 2025 | 4 articles | Viewed by 5402 | Submission Open
Keywords: farm animal; livestock; genome sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Genetics and Biosynthesis of Biotechnological Products by Filamentous Fungi and Yeasts submission deadline 20 May 2025 | 4 articles | Viewed by 5401 | Submission Open
Keywords: filamentous fungi; yeasts; eukaryotic organisms; primary and secondary metabolites; biotechnological products
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms in Tumorigenesis of NMSC
edited by and Panagiotis Kouklis
submission deadline 20 May 2025 | 2 articles | Viewed by 5383 | Submission Open
Keywords: skin cancer; NMSC; tumorigenesis; genetics; biomarkers; biology; microenvironment; exosomes
(This special issue belongs to the Section Molecular Oncology)
Diabetes: Regulation of Insulin Secretion in Pancreatic Beta Cells
edited by Alfonso Rubio-Navarro and Nicolás Gómez-Banoy
submission deadline 20 May 2025 | 2 articles | Viewed by 5338 | Submission Open
Keywords: beta cells; pancreatic islets; insulin secretion; insulin production; diabetes; hyperglycemia; beta cell heterogeneity
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Genetics and Epigenetics of Cardiometabolic Diseases
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 5275 | Submission Open
Keywords: obesity; insulin resistance; diabetes mellitus; cardiovascular diseases; metabolic syndrome; non-alcoholic fatty liver disease; dyslipidaemia; coronary artery disease; chronic kidney disease; hypertension
(This special issue belongs to the Section Molecular Genetics and Genomics)
Alzheimer’s Disease and Other Dementias—Molecular Therapeutic Approaches submission deadline 20 May 2025 | 2 articles | Viewed by 5237 | Submission Open
Keywords: dementia; prevention of dementia; treatment of dementia; amyloid tangles; tauopathies; mild cognitive impairment; neurodegenerative pathways; toxic elements inducing dementia; drug screening; drug design; cell or organelle therapy; device development; neurodegeneration; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Bioactive Materials with Antimicrobial Properties: 2nd Edition submission deadline 20 May 2025 | 3 articles | Viewed by 5200 | Submission Open
Keywords: bioactivity; biomedical application; smart packaging; aerospace; textile; antimicrobic activity; antifungal activity
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Cancer Invasion and Metastasis
edited by
submission deadline 20 May 2025 | 4 articles | Viewed by 5197 | Submission Open
Keywords: cancer; cancer invasion; metastasis; tumor microenvironment; molecular basis of cancer; immunotherapy; cell motility; cancer genetics; cancer development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: “Molecular Dynamics” submission deadline 20 May 2025 | 3 articles | Viewed by 5176 | Submission Open
Keywords: quantum mechanics; classical mechanics; hybrid QM/MM; molecular dynamics at the atomic level; steered molecular dynamics; coarse-graining; docking(protein– protein; protein– ligand); the molecular dynamics of protein– ligand interactions; drug design; virtual screening
(This special issue belongs to the Section Molecular Biophysics)
Musculoskeletal Disease: From Molecular Basis to Therapy
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 5158 | Submission Open
Keywords: musculoskeletal diseases; osteoporosis; osteoarthritis; sarcopenia; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genes Function and Mechanism Identification in Plant Stress Resistance: 3rd Edition
edited by
submission deadline 20 May 2025 | 4 articles | Viewed by 5128 | Submission Open
Keywords: cotton; plant abiotic stresses; drought resistance; high-temperature resistance; low-temperature resistance; salt resistance
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Advances in Hypercapnia
edited by Masahiko Shigemura
submission deadline 20 May 2025 | 4 articles | Viewed by 5089 | Submission Open
Keywords: carbon dioxide (CO2); hypercapnia; CO2 sensing mechanisms; hypercapnia-mediated signal; transduction pathways; beneficial effects of hypercapnia; detrimental effects of hypercapnia; humans; mammals; flies; nematodes; plants; marine animals
(This special issue belongs to the Section Molecular Biology)
Design and Application of Organic Superbases—from Theory to Experiment submission deadline 20 May 2025 | 3 articles | Viewed by 5054 | Submission Open
Keywords: organic superbases; computational study; synthesis; structrue-function relationship; catalysis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular and Cellular Characterizations: Reproductive Development in Plants
edited by Yanming Deng
submission deadline 20 May 2025 | 3 articles | Viewed by 4993 | Submission Open
Keywords: floral induction and organogenesis; flower bud development; meiosis; microsporogenesis; megasporogenesis; pollen development; pollen germination; pollen tube growth; embryo development and abortion; self-incompatibility; cross compatibility; cross reproductive barrier
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Research of Plant and Microbial Communities
edited by
submission deadline 20 May 2025 | 5 articles | Viewed by 4882 | Submission Open
Keywords: microbiome and mycobiome of soil and plant rhizosphere; mycorrhizal fungi; next-generation sequencing; soil biodiversity
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases
edited by
submission deadline 20 May 2025 | 2 articles | Viewed by 4794 | Submission Open
Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Inflammatory and Immune Response to Helicobacter pylori Infection
edited by Leonid B. Lazebnik and
submission deadline 20 May 2025 | 2 articles | Viewed by 4782 | Submission Open
Keywords: adhesion; antibiotics resistance; bacteriophages; chronic inflammation; dysbiosis; eradication; fucosylated glycan; gastric cancer; gastric microbiota; gut microbiota; Helicobacter pylori; H. pylori-associated gastritis; H. pylori differ stamms; host immune response; inflammasome; inflammatory response; innate immunity; Lewis system antigens; matrix metalloproteinases; microbial interaction; microbial metabolites; microRNA; molecular mimicry; non-coding RNA; oxidative stress; pathogen-associated molecular patterns; pattern recognition receptors; phytochemicals; postbiotics; probiotics; synthetic peptides; vaccine; virulence factors
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances and Insights on Diagnosis, Prevention and Therapeutics of Cardiovascular Diseases submission deadline 20 May 2025 | 2 articles | Viewed by 4776 | Submission Open
Keywords: cardiovascular disease; cardiovascular calcification; inflammation; oxidative stress; atherosclerosis; chronic kidney disease; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights in Reproductive Immunology and Placental Pathology, 2nd Edition
edited by
submission deadline 20 May 2025 | 4 articles | Viewed by 4725 | Submission Open
Keywords: gamete immunology; in vitro fertilization; infertility; immunocontraception; implantation; placentation; immunotolerance; reproductive immunology; inflammation; cytokine network; placenta-derived stem cells; placental development; placental insufficiency; endometriosis; immunopathology of pregnancy; sex hormones
(This special issue belongs to the Section Molecular Immunology)
Recent Advances in Biomolecule and Bioprocess Engineering for Sustainable Environment
edited by , and Chulhwan Park
submission deadline 20 May 2025 | 2 articles | Viewed by 4715 | Submission Open
Keywords: bioactive molecule; biocatalyst; biochar; bioconversion; biomass; biorefinery; biopolymer; bioprocess; biotechnology
(This special issue belongs to the Section Biochemistry)
Advancements in Pincer Ligand Chemistry
edited by
submission deadline 20 May 2025 | 2 articles | Viewed by 4702 | Submission Open
Keywords: pincer ligands; metal complexes; tridentate ligands; catalysis; organometallic chemistry; homogenous catalysis; ligand tunability
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Protein and Protein Interactions
edited by Wu Xu
submission deadline 20 May 2025 | 3 articles | Viewed by 4677 | Submission Open
Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics
(This special issue belongs to the Section Molecular Biology)
Glycosaminoglycans, 2nd Edition submission deadline 20 May 2025 | 3 articles | Viewed by 4652 | Submission Open
Keywords: biosynthesis of glycosaminoglycans; hyaluronan; chondroitin sulfate; heparin; modified GAGS; GAG bioactivity; GAGs as biomarkers; novel characterization methods; GAGs as drug or drug carriers; GAG= interaction with cells; in vitro cell-based assays; innovative biofabrication methodology based on GAGs; 3D scaffolds based on GAGs
(This special issue belongs to the Section Macromolecules)
Chitin: Structure, Modifications and Applications
edited by and
submission deadline 20 May 2025 | 3 articles | Viewed by 4628 | Submission Open
Keywords: chitin; nanotechnology; chemical modification; chitin-based biomaterials
(This special issue belongs to the Section Macromolecules)
New Insights into Immunity and Inflammation in Cardiovascular Diseases
edited by
submission deadline 20 May 2025 | 4 articles | Viewed by 4558 | Submission Open
Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation
(This special issue belongs to the Section Molecular Immunology)
Targeting Blood Vessels in Cancer and Fibrosis submission deadline 20 May 2025 | 2 articles | Viewed by 4551 | Submission Open
Keywords: blood vessels; angiogenesis; fibrosis; fibroblasts; hypoxia; pericytes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Mitochondria in Health and Diseases submission deadline 20 May 2025 | 4 articles | Viewed by 4476 | Submission Open
Keywords: mitochondrial bioenergetics; reactive oxygen species; apoptosis; aging; immune function; mtDNA mutations; mitochondrial dysfunction; mitochondria-targeted therapies
(This special issue belongs to the Section Biochemistry)
Unravelling Interactions between Amyloid Beta (Aβ) and Key Pathological Features of Alzheimer’s Disease
edited by Athanasios Metaxas
submission deadline 20 May 2025 | 1 articles | Viewed by 4475 | Submission Open
Keywords: Alzheimer’ s disease; amyloid; tau; neuroinflammation; synapses; metabolism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition
edited by and Giulia Russo
submission deadline 20 May 2025 | 3 articles | Viewed by 4418 | Submission Open
Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
The Role of Sugars in Plant Responses to Stress and Their Regulatory Function during Development—3rd Edition submission deadline 20 May 2025 | 2 articles | Viewed by 4418 | Submission Open
Keywords: sugar signaling; abiotic stress tolerance; biotic stress; plant responses; developmental regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Nanosorbent Materials submission deadline 20 May 2025 | 2 articles | Viewed by 4390 | Submission Open
Keywords: adsorption; adsorbents; nanomaterials; insight at the molecular level; experimental studies; theoretical studies; fundamentals; applications
(This special issue belongs to the Section Materials Science)
Macrophage Polarization: Learning to Manage It (4th Edition)
edited by
submission deadline 20 May 2025 | 2 articles | Viewed by 4370 | Submission Open
Keywords: macrophages; macrophage plasticity; macrophage polarization; innate immunity; IFN-γ ; TNF-α ; immunomodulators; diseases; homeostasis; inflammation; cancer
(This special issue belongs to the Section Molecular Immunology)
Nanomedicine Advances in the Treatment of Chronic Inflammation submission deadline 20 May 2025 | 2 articles | Viewed by 4368 | Submission Open
(This special issue belongs to the Section Molecular Nanoscience)
Recent Research of Natural Products from Microalgae and Cyanobacteria
edited by
submission deadline 20 May 2025 | 2 articles | Viewed by 4352 | Submission Open
Keywords: marine and fresh water microalgal and cyanobacterial bioactive compounds; microalgal and cyanobacterial carotenoids; vitamins; phenolics; and phycobiliproteins; microalgal and cyanobacterial alkaloids; microalgal and cyanobacterial polysaccharides; microalgal and cyanobacterial peptides; microalgal and cyanobacterial polyphenols; microalgal and cyanobacterial antioxidants; microalgal and cyanobacterial pharmaceuticals; microalgal and cyanobacterial nutraceuticals; microalgal and cyanobacterial anti-inflammatory compounds; microalgal and cyanobacterial antimicrobial compounds; microalgal and cyanobacterial anticancer compounds; microalgal and cyanobacterial neuroprotective compounds; microalgal and cyanobacterial antiviral compounds; microalgal and cyanobacterial-derived anti-aging compounds; microalgal and cyanobacterial extracts
(This special issue belongs to the Section Biochemistry)
The Roles of RNA (Coding and Non-coding) in Human Disease
edited by Lee Lee Wong
submission deadline 20 May 2025 | 3 articles | Viewed by 4343 | Submission Open
Keywords: coding RNA; non-coding RNA; biomarker; functional role; therapeutic targets  
(This special issue belongs to the Section Macromolecules)
Aging and Chronic Kidney Disease submission deadline 20 May 2025 | 2 articles | Viewed by 4312 | Submission Open
Keywords: chronic kidney disease; aging; age-related diseases; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Heart Failure: From Molecular Basis to Therapeutic Strategies
edited by
submission deadline 20 May 2025 | 3 articles | Viewed by 4311 | Submission Open
Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Yeasts: Model Systems for Molecular Research
edited by
submission deadline 20 May 2025 | 5 articles | Viewed by 4308 | Submission Open
Keywords: yeasts as a model organism; yeast genomics; DNA replication and repair; cell cycle and its regulation; transcription; translation and posttranslational modification; signal transduction; chromosomal biology; nuclear import and export; mitochondria; synthetic biology; yeast biotechnology; biomedicine; in lab evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
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