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The Roles of RNA (Coding and Non-coding) in Human Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 552

Special Issue Editor


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Guest Editor
1. Cardiovascular Research Institute, National University Health System, Singapore 117599, Singapore
2. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore
Interests: biomarkers; microRNAs; therapeutic; cardiovascular disease; breast cancer; signalling

Special Issue Information

Dear Colleagues,

RNA plays a multifaceted role in human disease, influencing pathogenesis at various levels. Beyond its fundamental role in protein synthesis, RNA is being increasingly recognized for its regulatory functions, impacting gene expression and cellular processes. Coding RNA and non-coding RNA represent two broad categories of RNA molecules with distinct roles in cellular processes. Coding RNA directs protein synthesis, and disruptions in its functionality contribute to diseases like cancer and neurodegeneration. Non-coding RNA, including microRNAs and long non-coding RNAs, intricately modulate gene expression and are implicated in diverse pathologies. RNA’s utility as a biomarker for disease diagnosis and prognosis is expanding, given its differential expression profiles in various conditions. Moreover, understanding RNA’s functional nuances provides insights into disease mechanisms, offering potential therapeutic targets. Innovative RNA-based therapies, such as RNA interference and antisense oligonucleotides, hold promise for precision medicine by targeting specific disease-related RNA aberrations. Unraveling the complex interplay of coding and non-coding RNA in human diseases not only refines diagnostic approaches but also opens avenues for developing novel, targeted therapeutics. In this Special Issue, we welcome the submission of research articles and full reviews.

Dr. Lee Lee Wong
Guest Editor

Manuscript Submission Information

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Keywords

  • coding RNA
  • non-coding RNA
  • biomarker
  • functional role
  • therapeutic targets
 

Published Papers (1 paper)

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Research

19 pages, 7067 KiB  
Article
MEG3-Mediated Oral Squamous-Cell-Carcinoma-Derived Exosomal miR-421 Activates Angiogenesis by Targeting HS2ST1 in Vascular Endothelial Cells
by Chia-Yun Huang, Sung-Tau Chou, Yuan-Ming Hsu, Wan-Ju Chao, Guan-Hsun Wu, Jenn-Ren Hsiao, Horng-Dar Wang and Shine-Gwo Shiah
Int. J. Mol. Sci. 2024, 25(14), 7576; https://doi.org/10.3390/ijms25147576 - 10 Jul 2024
Viewed by 282
Abstract
Exosomal microRNAs (miRNAs) from cancer cells play a key role in mediating the oral squamous cell carcinoma (OSCC) microenvironment. The objective of this study was to investigate how the long non-coding RNA (lncRNA) MEG3 affects OSCC angiogenesis through exosomal miR-421. Global miRNA microarray [...] Read more.
Exosomal microRNAs (miRNAs) from cancer cells play a key role in mediating the oral squamous cell carcinoma (OSCC) microenvironment. The objective of this study was to investigate how the long non-coding RNA (lncRNA) MEG3 affects OSCC angiogenesis through exosomal miR-421. Global miRNA microarray analysis and quantitative real-time PCR (qRT-PCR) were performed to determine the level of miRNAs in OSCC cell-derived exosomes. Cell migration, invasion, tube formation, immunohistochemistry, and hemoglobin concentrations were used to study the effects of exosomal miR-421 in angiogenesis. Western blotting was used to determine the expression level of HS2ST1 and VEGFR2-related downstream proteins. MiRNA array and qRT-PCR identified the upregulation of miR-421 in OSCC cell-derived exosomes. Furthermore, exosomal miR-421 can be taken up by human umbilical vein endothelial cells (HUVECs) and then target HS2ST1 through VEGF-mediated ERK and AKT phosphorylation, thereby promoting HUVEC migration, invasion, and tube formation. Additionally, forced expression of the lncRNA MEG3 in OSCC cells reduced exosomal miR-421 levels and then increased HS2ST1 expression, thereby reducing the VEGF/VEGFR2 pathway in HUVECs. Our results demonstrate a novel mechanism by which lncRNA MEG3 can act as a tumor suppressor and regulate endothelial angiogenesis through the exosomal miR-421/HS2ST1 axis, which provides a potential therapeutic strategy for OSCC angiogenesis. Full article
(This article belongs to the Special Issue The Roles of RNA (Coding and Non-coding) in Human Disease)
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