Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Special Issues

International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

Section

Search by Title/Keyword

Order results

Display

Results per page

Molecular Crosstalk Between Metabolic Dysregulation and Neuropsychiatric Disorders: Novel Therapeutic Perspectives

edited by Aleksandra Szopa and Anna D. Serefko

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut– brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

Mechanisms of Genotoxicity Induced by Environmental Mutagens—Focus on Nanoparticles and Micro/Nanoplastics

edited by

Ricard Marcos

and Susana Pastor

submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open

Keywords: genotoxicity; DNA damage; chromosome damage; DNA repair; comet assay; micronucleus assay; mechanisms; environmental pollutants; micro/nanoplastics; nanoparticles

(This special issue belongs to the Section Molecular Toxicology)

Breast Cancer and Hormone Receptors: Molecular Insights

edited by

Alkistis Papatheodoridi

and

Antonella Muscella

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Endometrial Cancer: From Molecular Mechanisms to Treatment

edited by Ursula Catena

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: endometrial cancer; molecular mechanisms; biomarkers; targeted therapy; immunotherapy; genomics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

The Role of Dopamine Neurotransmission in Schizophrenia

edited by

Mirian Akemi Furuie Hayashi

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: schizophrenia; dopamine; dopaminergic system; neurotransmission; psychosis; pathophysiology; molecular psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Novel Diagnostic and Theragnostic Strategies in Brain Tumors

edited by Andrea Cimini and Laura Travascio

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: brain tumor; novel diagnostic and theragnostic approaches; neuro-oncology; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

Multi-Target and Synergistic Therapeutic Strategies in Modern Drug Discovery

edited by

Vincenzo Piccolo

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: multi-target and synergistic therapeutic strategies; drug design; combination therapy; polypharmacology; drug re-purposing

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms, Epigenetics and Therapeutics in Liver Cirrhosis

edited by Ana Soledad Sandoval-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: liver cirrhosis; molecular pathogenesis; fibrosis and inflammation; epigenetics; hepatocellular carcinoma (HCC); viral hepatitis; molecular mechanism; hepatic nutrition; therapeutic targets; translational hepatology; MASLD; ALD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

Mitochondria: Not Just Powerhouse of the Cell

edited by

Kailash Chandra Mangalhara

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: mitochondrial nucleic acid; mitonuclear communication; mito-ER communication; mito-lysosome communication; mitochondria in cancer; mitochondrial metabolic disorders; mitochondria in inflammation

(This special issue belongs to the Section Molecular Biology)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair

edited by Rebeca Illescas Montes

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: fibroblast; wound healing; inflammation; tissue repair; immune– stromal crosstalk; extracellular matrix remodeling; myofibroblast; regenerative medicine; exosomes; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Involvement of Connexin-, Pannexin-, and Innexin-Based Hemichannels in Physiological Functions of Diverse Tissues

edited by

Juan Carlos Saéz

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: connexin; pannexin; innexin; hemichannel; permeant ions

(This special issue belongs to the Section Molecular Biology)

New Insight Into Pathogen Stress Effects on Plant Structure and Metabolism

edited by

Edmund Kozieł

and

Katarzyna Otulak-Kozieł

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: plant– pathogen interaction; innate immunity; ultrastructure; plant defense systems; plant physiology; signal transduction; resistance genes

(This special issue belongs to the Section Molecular Plant Sciences)

Application of Germplasm Innovation Technology in Aquactic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

Molecular Insights into Heredity and Metabolism of Osteosarcoma

edited by

Hiroki Kuniyasu

and

Kanya Honoki

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: osteosarcoma; clinical imaging; genetics; epigenetics; metabolism; signal transduction; stemness; pathology; metastasis; novel druggable target

(This special issue belongs to the Section Molecular Oncology)

Precision Nutrition and Cancer: Molecular Insights Into Cancer Prevention and Development

edited by

Da Pan

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: precision nutrition; cancer prevention; cancer development; nutrigenomics; personalized diets; tumor metabolism; dietary interventions

(This special issue belongs to the Section Molecular Oncology)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

The Structure, Function, and Application of Zinc Finger Proteins

edited by

Sabrina Esposito

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: zinc finger proteins: structure; function and properties; applications; protein folding and dynamics; environmental contaminants and metal ions exposure; uptake; toxicity; molecular recognition and signal transduction; mechanisms of action and effects of abnormal zinc finger proteins on human health; zinc finger proteins as drug targets

(This special issue belongs to the Section Molecular Biology)

Tumor Organoids in Translational Cancer Research: Mechanisms and Applications

edited by Yong-Jun Kwon

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: tumor organoids; tumor heterogeneity; multi-omics profiling; drug resistance; tumor microenvironment; patient-derived models; organoid biobank; high-throughput drug screening; personalized therapy; translational research

(This special issue belongs to the Section Molecular Oncology)

Exploring the Chemistry of 2D Transition Metal Carbides and Nitrides (MXenes): Synthesis Methods and Surface Chemistry

edited by

Hyunho Kim

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: synthesis optimization of non-Al MAX phase; wet chemical etching of non-Al MAX phase; molten salt etching of non-Al MAX phase; surface modification of MXenes; colloidal stability of MXenes; solution process of MXenes

(This special issue belongs to the Section Materials Science)

Mechanobiology of the Cell

edited by

Zbigniew Baster

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: nuclear and chromatin mechanics; mechanobiology; mechanotransduction pathways

(This special issue belongs to the Section Molecular Biology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

Micro- and Nanoplastics: Molecular Insights from the One Health Perspective

edited by

Magdalena Zemelka-Wiacek

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: microplastics; nanoplastics; One Health; molecular toxicology; oxidative stress; inflammation; microbiome; bioaccumulation; environmental exposure

(This special issue belongs to the Section Molecular Toxicology)

Molecular Insights in Women’s Health: Advances in Gynecological Disease Mechanisms and Therapeutics

edited by Tsung-Hsuan Lai

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: ART and IVF; prenatal diagnosis; infertility; minimally invasive surgery; robotic surgery; PCOS; endometriosis; menopause; AI

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Decoding the Pediatric Brain Tumor Microenvironment: A Molecular Perspective

edited by

Samuele Tardito

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: pediatric brain tumor; precision immunotherapy; pediatric neuro-oncology; tumor microenvironment (TME); single-cell RNA sequencing; whole transcriptomics; mass spectrometry-based proteomics; mass cytometry; cellular and molecular architecture; organoid

(This special issue belongs to the Section Molecular Oncology)

Nanoparticles in Nanobiotechnology and Nanomedicine: 3rd Edition

edited by

Costica Caizer

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: nanoparticles; properties of nanoparticles; methods of obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

Natural Compounds: Impact on Health and Diseases

edited by

Charles Benneh

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: natural compounds; bioactive compounds; efficacy; toxicity; mechanism; compound isolation; chemical characterisation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by

Daniel P. Potaczek

submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications

edited by Marius Rǎdulescu

submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open

Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure– property relationships; functionalized silica; sol– gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling

(This special issue belongs to the Section Molecular Nanoscience)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K– MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Haris Charalambous

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome

(This special issue belongs to the Section Molecular Oncology)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

Smart Biomolecular Nanocarriers for Precision Cancer Therapy and Diagnosis

edited by

Atul Garkal

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: nanobiotechnology; anti-cancer agents; nanocarrier; targeted drug delivery

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Zoonoses and Vector-Borne Diseases

edited by Ravi Durvasula

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: malaria; leishmaniasis; soil-transmitted helminths; one health; cryptosporidiosis; trypanosomiasis; mosquito-borne infections; arboviral diseases; paratransgenesis; drug discovery; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biomarkers in Mood Disorders

edited by Lionella Palego and

Valerio Dell’Oste

submission deadline 30 Apr 2026 | Viewed by 26 | Submission Open

Keywords: mood disorders; etiopathogenesis; genetics/epigenetics; RNA analyses; neuroendocrinology; inflammation; molecular markers

(This special issue belongs to the Section Molecular Neurobiology)

Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by Jerran Santos

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Assisted Reproductive Technology

edited by Nuria Marti-Gutierrez

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: cytoplasm maternal factors; mitochondrial replication; meiosis; chromosome pairing; recombination; gene editors

(This special issue belongs to the Section Molecular Biology)

Progress in Photobiomodulation Therapy

edited by

Amílcar Sabino Damazo

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: photobiomodulation (PBM); low-level light therapy (LLLT); light-emitting diodes (LEDs); mitochondrial photostimulation; anti-inflammatory effects; tissue regeneration; neuromodulation; biostimulation; clinical applications; pain management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Brucella Research

edited by

Angel Oñate

submission deadline 30 Apr 2026 | Viewed by 21 | Submission Open

Keywords: Brucella abortus; molecular pathogenesis; host– pathogen interaction; virulence factors; oxidative stress response; intracellular survival; immune evasion; exosomes; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Nanoscale Materials for Advanced Electrocatalysts

edited by