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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Adsorption Science: From Molecular Mechanisms to Practical Applications submission deadline 28 Feb 2027 | Viewed by 86 | Submission Open
Keywords: adsorption mechanisms; surface science; molecular mechanisms; heterogeneous catalysis; water treatment; interfacial phenomena; molecular modeling; functional nanomaterials; kinetics and thermodynamics
(This special issue belongs to the Section Molecular Biophysics)
Deep Learning–Enabled Smart Phenotyping: From Multi-Omics Data Integration to Molecular Mechanism Elucidation
edited by Jie Jiang and
submission deadline 28 Feb 2027 | Viewed by 81 | Submission Open
Keywords: deep learning; smart phenotyping; multi-omics integration; computer vision; convolutional neural networks; transformers; graph neural networks; multimodal fusion; high-throughput phenotyping; genome-wide association studies; molecular mechanism; regulatory network inference; explainable AI; gene discovery; crop improvement; temporal dynamics; representation learning; systems biology; intelligent agriculture
(This special issue belongs to the Section Molecular Informatics)
Artificial Intelligence in Molecular Medicine and Human Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 78 | Submission Open
Keywords: artificial intelligence; molecular medicine; human diseases; machine learning; deep learning; precision medicine; biomarker discovery; multi-omics integration; genomics; transcriptomics; proteomics; metabolomics; molecular signatures; disease mechanisms; systems biology; molecular networks; therapeutic targets; predictive modeling; explainable AI
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms of Plant–Soil–Water Interactions Under Agricultural Water Stress
edited by Saif Ullah and
submission deadline 28 Feb 2027 | Viewed by 73 | Submission Open
Keywords: molecular plant–water interactions; plant–soil–water nexus; aquaporins; water-use efficiency (WUE); drought stress signaling; abscisic acid (ABA); root system architecture; plant hydraulics; transcriptomics; proteomics; metabolomics; epigenetic regulation; rhizosphere microbiome; salinity tolerance; climate-resilient crops
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research Advances in Additive Manufacturing
edited by and Wenzhi Xu
submission deadline 28 Feb 2027 | Viewed by 72 | Submission Open
Keywords: additive manufacturing; molecular mechanisms; microstructural design; polymerization kinetics; molecular dynamics simulation
(This special issue belongs to the Section Materials Science)
Mechanobiology of the Cell Membrane and Cytoskeleton: From Force Sensing to Therapeutic Targeting
edited by
submission deadline 28 Feb 2027 | Viewed by 70 | Submission Open
Keywords: mechanical forces; magnetic fields; cell cytoskeleton; cell division; gene expression
(This special issue belongs to the Section Molecular Biology)
From Multi-Omics Discovery and Functional Validation to Translational Applications in Cancer
edited by Luísa Pereira, Lúcio Lara Santos and
submission deadline 28 Feb 2027 | Viewed by 67 | Submission Open
Keywords: cancer; omics; functional testing; experimental models; underrepresented ancestries; artificial intelligence/machine learning; translational research
(This special issue belongs to the Section Molecular Genetics and Genomics)
Pharmacology of Neuropathic and Inflammatory Pain
edited by and Hector Isaac Rocha-González
submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: neuropathic pain; inflammatory pain; diabetic neuropathy; neuropharmacology; neuroinflammation; ion channels; sexual dimorphism; precision pain medicine; pharmacogenomics; proteomics, transcriptomics, and metabolomics in analgesic discovery
(This special issue belongs to the Section Molecular Pharmacology)
Latest Advances in Novel Luminescent Materials
edited by K. Naveen Kumar
submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: luminescent materials; rare-earth ions; nanophosphors; quantum dots; glass-ceramics; photoluminescence; upconversion luminescence; optical materials; photonic applications; light-emitting devices
(This special issue belongs to the Section Materials Science)
Molecular Networks Regulating Plant Organ Growth
edited by Yueya Zhang
submission deadline 28 Feb 2027 | Viewed by 60 | Submission Open
Keywords: plant organ growth; molecular regulatory; organ morphogenesis; developmental regulation; cell growth and differentiation; signaling regulation; environmental responses
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Biofilm Management: Current Challenges and Future Directions in Eradication Strategies
edited by and Hilal Başak Erol
submission deadline 28 Feb 2027 | Viewed by 58 | Submission Open
Keywords: biofilm management; eradication strategies; phenotypic tolerance; standardization of methodologies; synergistic therapy
(This special issue belongs to the Section Molecular Microbiology)
Molecular Design and Mechanistic Insights into Sustainable Polymers
edited by Lucia Caporaso
submission deadline 28 Feb 2027 | Viewed by 57 | Submission Open
Keywords: sustainable polymers; molecular design; polymerization catalysis; reaction mechanisms; computational chemistry; density functional theory; ring-opening polymerization; CO2 utilization; chemical recycling; circular polymer economy
(This special issue belongs to the Section Materials Science)
Disease Models and Molecular Mechanisms in Cardiovascular Development and Remodeling submission deadline 28 Feb 2027 | Viewed by 56 | Submission Open
Keywords: heart failure; CRISPR; LNPS; polymer; regeneration; fibrosis; therapy; animal model; target therapy; angiogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Metabolic Inflammation in Diabetic Complications, Metabolic Disorders, and Cancer Progression
edited by Dong-Keon Lee and
submission deadline 28 Feb 2027 | Viewed by 55 | Submission Open
Keywords: metabolic inflammation; inflammatory signaling; type 2 diabetes; insulin resistance; diabetic complications; oxidative stress; mitochondrial dysfunction; cancer progression
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exercise, Aging and Molecular Homeostasis
edited by and Daniela Vitucci
submission deadline 28 Feb 2027 | Viewed by 54 | Submission Open
Keywords: exercise; aging; molecular homeostasis; mitochondria; multi-omics; senescence; inflammation; skeletal muscle
(This special issue belongs to the Section Molecular Biology)
New Insights into Bacterial, Fungal, and Plant Lipids: From Structural Diversity to Biological Functions and Applications submission deadline 28 Feb 2027 | Viewed by 53 | Submission Open
Keywords: lipidomics; glycerolipids; sphingolipids; sterols; oxylipins; plant lipids; fungal lipids; bacterial lipids
(This special issue belongs to the Section Molecular Biology)
Molecular Innovations and Precision Medicine in Liver Diseases: From Mechanisms to Clinical Practice submission deadline 28 Feb 2027 | Viewed by 53 | Submission Open
Keywords: liver diseases; precision hepatology; metabolic dysfunction-associated steatotic liver disease (MASLD); molecular biomarkers; molecular imaging; multi-omics; liver regeneration; liver transplantation; artificial intelligence; nanomedicine; targeted drug delivery; GLP-1 therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Marine Natural Products and Their Derivatives
edited by
submission deadline 28 Feb 2027 | Viewed by 52 | Submission Open
Keywords: marine natural products; bioactive compounds; bioactive peptides; marine by-products; functional foods; nutraceuticals; structure–activity relationship; molecular docking; molecular dynamics simulation; circular bioeconomy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Nutrition and Chronic Metabolic Diseases Prevention: Molecular Exploration
edited by
submission deadline 28 Feb 2027 | Viewed by 51 | Submission Open
Keywords: nutrition; chronic metabolic diseases; molecular mechanism; phytochemicals; diabetes; atherosclerosis; metabolic health; nicotinamide mononucleotide; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Latest Research on Plant Genomics and Genome Editing, 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 49 | Submission Open
Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Plant Breeding and Genetic Improvement submission deadline 28 Feb 2027 | Viewed by 48 | Submission Open
Keywords: marker-assisted selection (MAS); CRISPR/Cas genome editing; genomic selection (GS); genome-wide association studies (GWAS); quantitative trait loci (QTL) mapping; abiotic and biotic stress tolerance; functional genomics; transcriptomics and metabolomics; plant genetic resources; crop quality improvement; climate-resilient agriculture; sustainable crop production; epigenetics and gene regulation; high-throughput phenotyping; agrobiotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Neuro-Oncology: Biomarkers and Mechanisms
edited by
submission deadline 28 Feb 2027 | Viewed by 47 | Submission Open
Keywords: brain tumors; glioma; glioblastoma; targeted therapy; precision medicine; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
Imaging Biomarkers in Cardiovascular Disease submission deadline 28 Feb 2027 | Viewed by 46 | Submission Open
Keywords: molecular imaging; cardiovascular disease; precision medicine; radiomics; molecular biomarkers; echocardiography; multi-omics; cardiac MRI
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Horticultural Crops
edited by
submission deadline 28 Feb 2027 | Viewed by 45 | Submission Open
Keywords: berry quality and postharvest physiology; developmental and reproductive biology; functional genomics and precision breeding (GWAS, CRISPR); stress responses and secondary metabolism
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress, Inflammation, and Insulin Resistance in Obesity and Metabolic Syndrome
edited by
submission deadline 28 Feb 2027 | Viewed by 42 | Submission Open
Keywords: oxidative stress; metabolic syndrome; obesity; mitochondrial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Effects of Nanoparticle Application in Plant Physiology
edited by and Camila Neves Lange
submission deadline 28 Feb 2027 | Viewed by 39 | Submission Open
Keywords: nanotechnology in agriculture; nano-enabled fertilizers; plant–nanoparticle interactions; plant physiology; abiotic stress tolerance; biofortification
(This special issue belongs to the Section Molecular Plant Sciences)
Adipogenesis in Health and Disease: Molecular Mechanisms, Multi-Omics and Precision Medicine submission deadline 28 Feb 2027 | Viewed by 37 | Submission Open
Keywords: adipogenesis; adipocyte; adipose tissue; lipid metabolism; metabolic diseases; genetic diseases; multi-omics; precision medicine; metabolic health
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Application of Natural Product in Nanotechnology
edited by Volodymyr Tkach
submission deadline 28 Feb 2027 | Viewed by 37 | Submission Open
Keywords: natural products; nanotechnology; nanomedicine; green synthesis; nanoparticles; drug delivery; phytochemicals; polyphenols; flavonoids; nanoformulations; biomaterials; controlled release; nanotoxicology; sustainable nanotechnology; bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Iron Metabolism in Cancer: Mechanisms and Therapeutic Targeting
edited by Michael Petronek
submission deadline 28 Feb 2027 | Viewed by 36 | Submission Open
Keywords: iron metabolism; redox biology; ferroptosis; tumor progression; cancer therapy; iron–sulfur clusters; heme proteins; ferritinophagy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Brain Tumours submission deadline 28 Feb 2027 | Viewed by 35 | Submission Open
Keywords: IGF; glioblastoma; nephroblastoma; cancer genetics; antisense therapy
(This special issue belongs to the Section Molecular Oncology)
Comparative and Functional Genomics of Plants
edited by Swapan Chakrabarty and
submission deadline 28 Feb 2027 | Viewed by 34 | Submission Open
Keywords: pangenome; genome evolution; systems biology; regulatory pathways; gene function
(This special issue belongs to the Section Molecular Genetics and Genomics)
Pathogenesis of Endometriosis, Disease Stratification, Diagnosis and Therapy
edited by Katharina Proestling and
submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open
Keywords: endometriosis; biomarkers; inflammation; fibrosis; oxidative stress; epigenetics; genetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA Regulation and Satellite Cell-Opathies: Molecular Pathogenesis and Therapeutic Frontiers in Neuromuscular Diseases submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open
Keywords: satellite cells; neuromuscular disorders; alternative splicing; satellite cell-opathies; RNA-binding proteins; RNA therapeutics; molecular pathogenesis; myogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research on Cardiovascular Endocrinology and Metabolism
edited by
submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open
Keywords: cardiovascular endocrinology; cardiovascular disease; endocrine signaling; cardiometabolic disorders; diabetes mellitus; obesity; hormones; endothelial dysfunction; cardiac remodeling; inflammation; oxidative stress; biomarkers; precision medicine; translational research; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pyroptosis, Ferroptosis and Necroptosis in Cardiovascular Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 31 | Submission Open
Keywords: pyroptosis; ferroptosis; necroptosis; inflammation; NLRP3 inflammasome; pro-inflammatory cytokines; lipid peroxidation; oxidative stress; receptor-interacting protein kinases (RIPKs); mixed lineage kinase domain-like protein (MLKL)
(This special issue belongs to the Section Molecular Biology)
Molecular Toxicology: How Environmental Pollutants Shape the Epigenome
edited by José Francisco Herrera Moreno and Diana Marcela Paredes-Céspedes
submission deadline 28 Feb 2027 | Viewed by 30 | Submission Open
Keywords: molecular toxicology; environmental health; environmental pollutants; epigenetics; multi-omics; biomarkers; human health; gene regulation; toxicology; environmental epidemiology
(This special issue belongs to the Section Molecular Toxicology)
Viral Infections and Immune Responses—2nd Edition submission deadline 28 Feb 2027 | Viewed by 29 | Submission Open
Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralising activity
(This special issue belongs to the Section Molecular Immunology)
Immunobiology of Metabolic Regulation and Aging
edited by and Masaki Ohmuraya
submission deadline 28 Feb 2027 | Viewed by 26 | Submission Open
Keywords: age-related diseases; aging vascular endothelial cells; healthy lifespan; organ-specific niche; senescence-associated (SA) immune cells; senescence-associated (SA) metabolism; super-aging society; tertiary lymphoid structures
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Metabolic Programming: Control of Gene Expression in Health and Disease
edited by
submission deadline 28 Feb 2027 | Viewed by 26 | Submission Open
Keywords: metabolic programming; gene regulation; immunometabolism; oncometabolism; acetyl-CoA; epigenetics; transcription; NAD; one-carbon metabolism; metabolic biosensors
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Molecular Insights into Ischemia/Reperfusion: 3rd Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 25 | Submission Open
Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular and Cellular Mechanisms of Autoimmune Diseases
edited by Stelvio Tonello and
submission deadline 28 Feb 2027 | Viewed by 23 | Submission Open
Keywords: autoimmunity; NETosis; biomarkers; pathology; autoimmune disease; pharmacological response; immunological modulation
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Immune Responses in Infectious Diseases: From Genes and Protein Interactions to Disease Outcomes submission deadline 28 Feb 2027 | Viewed by 23 | Submission Open
Keywords: infectious diseases; immune response; molecular immunology; host–pathogen interactions; immune-related genes; protein–protein interactions; cytokines; biomarkers; molecular mechanisms; disease severity; mortality; genomics; transcriptomics; proteomics; bioinformatics; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Tumor Microenvironment and Precision Therapeutics: From Biological Insights to Clinical Applications in Solid and Hematological Malignancies
edited by and Eleni D. Kapsali
submission deadline 28 Feb 2027 | Viewed by 20 | Submission Open
Keywords: tumor microenvironment; precision oncology; precision therapeutics; solid tumors; hematological malignancies; tumor heterogeneity; immunotherapy; targeted therapy; cellular therapy; therapeutic resistance; biomarkers; molecular profiling; single-cell sequencing; stromal cells; cancer-associated fibroblasts; extracellular matrix; extracellular vesicles; liquid biopsy; translational oncology; personalized medicine
(This special issue belongs to the Section Molecular Oncology)
Advances in the Molecular Pathogenesis, Diagnosis and Treatment of Inherited Metabolic Diseases
edited by
submission deadline 28 Feb 2027 | Viewed by 19 | Submission Open
Keywords: inherited metabolic disease; inborn errors of metabolism; newborn screening; mitochondrial disorders; lysosomal storage diseases; congenital disorders of glycosylation; organic acidurias; amino acid disorders; fatty acid oxidation defects; peroxisomal disorders; urea cycle defects
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Inflammatory, Metabolic, and Redox Biomarkers in Oncology submission deadline 28 Feb 2027 | Viewed by 17 | Submission Open
Keywords: oncology; biomarkers; inflammation; cancer metabolism; oxidative stress; redox biology; tumor microenvironment; treatment response; therapeutic resistance; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Extracellular Vesicle-Mediated Communication in Tumor Progression and Metastasis
edited by Sze Keong Tey
submission deadline 28 Feb 2027 | Viewed by 16 | Submission Open
Keywords: extracellular vesicles; exosomes; tumor progression; cancer metastasis
(This special issue belongs to the Section Molecular Oncology)
Molecular Research and Targeted Therapies of Cardiovascular Diseases
edited by Christos Kourek
submission deadline 28 Feb 2027 | Viewed by 16 | Submission Open
Keywords: cardiovascular diseases; molecular mechanisms; targeted therapy; endothelial progenitor cells; endothelial dysfunction; angiogenesis and vascular repair; cardiac regeneration; biomarkers; precision medicine; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Interactions in Drug Delivery: From Design to Therapeutic Outcomes
edited by Wenhao Wang
submission deadline 28 Feb 2027 | Viewed by 15 | Submission Open
Keywords: molecular interactions; drug delivery; self-assembly carrier; protein corona; nano–bio interface; targeted delivery; in vivo fate; pharmacokinetics
(This special issue belongs to the Section Molecular Pharmacology)
State-of-the-Art "Molecular Oncology" in Spain
edited by
submission deadline 28 Feb 2027 | Viewed by 14 | Submission Open
Keywords: molecular oncology; molecular pathology; sarcomas; solid tumors; RNA sequencing; DNA sequencing; epigenomics; multidisciplinary team; clinicopathological correlation
(This special issue belongs to the Section Molecular Oncology)
Molecular Biomarkers and Multi-Omics in Neurological and Neuropsychiatric Disorders submission deadline 28 Feb 2027 | Viewed by 13 | Submission Open
Keywords: molecular biomarkers; multi-omics; translational neuroscience; precision medicine; neurodegeneration; neuropsychiatric disorders; blood biomarkers; cerebrospinal fluid; proteomics; personalized medicine
(This special issue belongs to the Section Molecular Neurobiology)
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