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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Genetics in Ovarian Cancer (2nd Edition)

edited by

Bruna Scaggiante

submission deadline 31 Dec 2026 | Viewed by 141 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular, Metabolic, and Endocrine Mechanisms in Reproduction

edited by Aleksandra Stefanović

submission deadline 31 Dec 2026 | Viewed by 141 | Submission Open

Keywords: reproductive disorders; pregnancy complications; obesity; inflammation; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Immunology in Health and Disease

edited by

Adli Ali

submission deadline 31 Dec 2026 | Viewed by 139 | Submission Open

Keywords: immunodeficiencies; autoimmunity; inflammation; immunometabolism; neuroinflammation; immunotherapy; immunophenotyping; biomarkers; infection; precision medicine; immunogenetics

(This special issue belongs to the Section Molecular Immunology)

Cellular and Molecular Mechanisms of Exercise-Induced Tissue Adaptation in Health, Disease and Performance

edited by

Gilberto E. Shiguemoto

and

Wladimir Rafael Beck

submission deadline 31 Dec 2026 | Viewed by 136 | Submission Open

Keywords: skeletal muscle plasticity; exerkines and tissue crosstalk; molecular signaling pathways; exercise training adaptation; mitochondrial function; mitokines and metabolic crosstalk; epigenetic regulation; myokines

(This special issue belongs to the Section Molecular Biology)

Natural Bioactive Compounds: Green Extraction and Applications

edited by Milica Atanacković Krstonošić

submission deadline 31 Dec 2026 | Viewed by 135 | Submission Open

Keywords: bioactive molecules; green extraction; spectrometry; chromatography; delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Biomaterial Advances in Tissue Engineering

edited by

Haishan Shi

and

Jinfeng He

submission deadline 31 Dec 2026 | Viewed by 134 | Submission Open

Keywords: tissue engineering; regenerative medicine; biomaterials; stem cells; 3D bioprinting; molecular mechanisms; extracellular matrix

(This special issue belongs to the Section Materials Science)

Functional Genomics of Rare Variants in Human Disease

edited by

Salvatore Saccone

submission deadline 31 Dec 2026 | Viewed by 131 | Submission Open

Keywords: rare genetic variants; functional genomics; variant interpretation; next-generation sequencing; genome editing; neurodevelopmental disorders; Mendelian diseases; multi-omics integration; gene regulation; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Aquaculture Biology

edited by Jorge Olmos-Soto

submission deadline 31 Dec 2026 | Viewed by 131 | Submission Open

Keywords: transcriptomics; proteomics; metabolomics; immunomics; host–pathogen interactions; microbiome engineering; next-generation probiotics; recombinant vaccines; epigenetics; molecular diagnostics

(This special issue belongs to the Section Molecular Biology)

Pharmacological Advances of Epilepsy

edited by

Noemí Cárdenas-Rodríguez

Cindy Bandala

and Iván Ignacio-Mejía

submission deadline 31 Dec 2026 | Viewed by 130 | Submission Open

Keywords: epilepsy; antiseizure medications; pharmacology; epileptogenesis; drug resistance epilepsy; neuroinflammation; pharmacogenomics; oxidative stress; molecular targets; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Applications of Phage Infection and Host Resistance

edited by Rajnikant Sharma

submission deadline 31 Dec 2026 | Viewed by 130 | Submission Open

Keywords: bacteriophages; phage therapy; phage–host interactions; bacterial host resistance; antimicrobial resistance; biotechnology applications

(This special issue belongs to the Section Molecular Microbiology)

Advances in Bioactive Phytochemicals of Plant Origins

edited by

Onur Ketenoglu

submission deadline 31 Dec 2026 | Viewed by 128 | Submission Open

Keywords: bioactivity; plant; phenolics; toxicity; health-promoting attributes; phytochemicals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Gut Microbiota in Disease Pathophysiology and Therapy

edited by

Dulcenombre Gómez Garre

submission deadline 31 Dec 2026 | Viewed by 127 | Submission Open

Keywords: gut microbiota; dysbiosis; microbial metabolites; host–microbiota interactions; microbiome-targeted therapy; fecal microbiota transplantation; probiotics and postbiotics; gut–brain axis; metabolic and immune-mediated diseases; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Basis of Chronic Pain

edited by

Kuthati Yaswanth

submission deadline 31 Dec 2026 | Viewed by 127 | Submission Open

Keywords: neuro–immune crosstalk; chondroprotection; subchondral bone remodeling; central sensitization; nociceptive signaling pathways; health supplements

(This special issue belongs to the Section Molecular Neurobiology)

Insights in Reproductive Immunology: The Immune Regulation at the Maternal-Fetal Interface in Health and Disease

edited by Mariana Cristina Ferrero and

Andrea M. Canellada

submission deadline 31 Dec 2026 | Viewed by 127 | Submission Open

Keywords: reproductive immunology; maternal–fetal interface; uterine immune cells; extracellular vesicles; gonadal disfunction; sperm-induced inflammation; immune tolerance; immunometabolism; endometriosis; pregnancy complications; microbiome; single-cell and multi-omics; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Updates on Pathogenesis and Molecular Targets of Alzheimer’s Disease

edited by Jean-Pierre Brion and Kunie Ando

submission deadline 31 Dec 2026 | Viewed by 125 | Submission Open

Keywords: Alzheimer’s disease; tau; amyloid; neurodegenerative diseases; inflammation; biomarkers; genetic variants; risk factors; protein-protein interactions; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Bridging Molecular and Translational Research in Chronic Kidney Disease and Dysmetabolism

edited by

Gianluigi Zaza

Francesca Tinti

, Lida Tartaglione and

Silvia Lai

submission deadline 31 Dec 2026 | Viewed by 124 | Submission Open

Keywords: chronic kidney disease; translational research; dysmetabolism; biotechnologies; bone diseases; inflammation; oxidative stress; omics; personalize medicine; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Health and Diseases

edited by

Jinnatun Nahar

submission deadline 31 Dec 2026 | Viewed by 122 | Submission Open

Keywords: natural products; phytochemicals; bioactive compounds; molecular mechanisms; drug delivery; antioxidant activity; anti-inflammatory activity; antimicrobial resistance; cancer therapeutics; nanoformulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Physicochemical Research Progress of Orthodontic Materials: From Metal Alloys to Dental Resins

edited by

Marcin Mikulewicz

submission deadline 31 Dec 2026 | Viewed by 118 | Submission Open

Keywords: orthodontic archwires; ion release; acrylic resin; colour stability; surface roughness; corrosion; dental materials; biomechanics; microbial colonisation; prosthodontics; orthodontics; oral environment

(This special issue belongs to the Section Materials Science)

Neuroinflammation: Molecular Targets and Therapeutic Advances

edited by

Tamás Körtési

submission deadline 31 Dec 2026 | Viewed by 118 | Submission Open

Keywords: neuroinflammation; neuroimmune signaling; migraine; neuropeptides; glutamatergic system; kynurenine pathway; microglia; astrocytes; neurodegeneration; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Evolution of Plant Genomes and Stress Adaptation

edited by

Zhonghu Li

submission deadline 31 Dec 2026 | Viewed by 117 | Submission Open

Keywords: plant genomics; molecular evolution; population genetics; stress adaptation; lineage divergence

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Biomarkers in Allergic and Immune-Mediated Diseases

edited by

Luisa Ricciardi

submission deadline 31 Dec 2026 | Viewed by 112 | Submission Open

Keywords: allergy; clinical immunology; autoimmune diseases; IgE; auto-antibodies; biomarkers; inflammation

(This special issue belongs to the Section Molecular Immunology)

Natural Products: Molecular Mechanisms and Bioactivities

edited by

Pınar Kadiroğlu Kelebek

submission deadline 31 Dec 2026 | Viewed by 110 | Submission Open

Keywords: natural products; bioactive compounds; molecular mechanisms; anti-inflammatory activity; immune response; antimicrobial activity; fermentation; lactic acid bacteria; functional foods; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neuroimmune Crosstalk Across Neurodegenerative Disorders

edited by Muhammad Sohail Khan

submission deadline 31 Dec 2026 | Viewed by 109 | Submission Open

Keywords: neuroimmune crosstalk; neuroinflammation; neurodegeneration; microglia astrocytes; Alzheimer’s disease; Parkinson’s disease; extracellular vesicles; biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research and Developments in Antimicrobial Natural Products

edited by

Ki-Young Kim

submission deadline 31 Dec 2026 | Viewed by 108 | Submission Open

Keywords: antimicrobial natural products; antimicrobial resistance; plant-derived antimicrobials; microbial secondary metabolites; marine; natural products; antimicrobial peptides; lead compound discovery; mechanism of action; AI-assisted drug discovery; translational development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Strategies for Spinal Cord Injury: Cellular and Molecular Targets for SCI Repair and Recovery

edited by Karen L. Lankford

submission deadline 31 Dec 2026 | Viewed by 107 | Submission Open

Keywords: spinal cord injury; chronic; acute; miRs; mRNA; inflamasome; extracellular matrix; integrins; neurogenesis; myelin; sulphate proteoglycans (CSPG); myelin-derived inhibitors (MAIs)

(This special issue belongs to the Section Molecular Neurobiology)

Spinal Muscular Atrophy: From Genetics to Therapeutics

edited by Eduardo F. Tizzano and

Lucia Tabares

submission deadline 31 Dec 2026 | Viewed by 104 | Submission Open

Keywords: spinal muscular atrophy; motor neuron; survival motor neuron genes; genetic modifiers; disease-modifying therapies; multisystemic disease; synapsis; later-onset phenotypes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds in Cancer Therapy and Prevention, 3rd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 31 Dec 2026 | Viewed by 102 | Submission Open

Keywords: cancer therapy; cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Biomedical and Biological Applications of Organic Chemical Molecules and Materials

edited by Katarzyna Kotwica-Mojzych

submission deadline 31 Dec 2026 | Viewed by 101 | Submission Open

Keywords: organic molecules; medicinal chemistry; heterocyclic compounds; biomaterials; nanomaterials; drug discovery; anticancer agents; molecular mechanisms; tissue engineering; regenerative medicine

(This special issue belongs to the Section Materials Science)

Molecular Research on Hypertension, Diabetes and Obesity

edited by

Shin-Da Lee

submission deadline 31 Dec 2026 | Viewed by 100 | Submission Open

Keywords: hypertension; diabetes; obesity; metabolic syndrome; cardiometabolic; neurocardiometabolic; endothelial dysfunction; oxidative stress; inflammation; apoptosis; cardiovascular disease with comorbidity; chronic kidney disease with comorbidity; neurology disease with comorbidity; exercise training; pharmacological intervention; nutritional intervention; precision medicine; biomarkers; molecular mechanisms; translational medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Transition Metal Catalysis: Constructing Complex Structures and Introducing Chirality

edited by Guodu Liu

submission deadline 31 Dec 2026 | Viewed by 96 | Submission Open

Keywords: transition metal catalysis; asymmetric synthesis; chiral ligands; cross-coupling reactions; catalytic hydrogenation; organometallic chemistry; synthetic methodology; homogeneous catalysis; total synthesis; medicinal chemistry; chemical biology

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Biology and the Genetic Breeding of Aquatic Animals: Breakthroughs and Challenges (3rd Edition)

edited by

Hongyan Xu

and

Ke Feng

submission deadline 31 Dec 2026 | Viewed by 95 | Submission Open

Keywords: transgenic; genetic breeding; omics; gene expression and regulation; aquatic animals

(This special issue belongs to the Section Molecular Biology)

Bio/Synthesis, Design and Characterization of Materials from Natural Resources

edited by

Catalina Natalia Cheaburu-Yilmaz

submission deadline 31 Dec 2026 | Viewed by 94 | Submission Open

Keywords: biosynthesis; biopolymers; green chemistry; functional materials; renewable resources; electroactive materials

(This special issue belongs to the Section Materials Science)

Advances and Perspectives in Cyanobacterial Research

edited by

Mathias Chia

submission deadline 31 Dec 2026 | Viewed by 92 | Submission Open

Keywords: cyanobacteria; molecular biology; genomics; transcriptomics; proteomics; metabolomics; cyanotoxins; secondary metabolites; nitrogen fixation; synthetic biology

(This special issue belongs to the Section Molecular Plant Sciences)

Neutrophils in Human and Animal Reproduction: Functions, Disorders, and Therapeutic Potential

edited by

Fabiola Zambrano

submission deadline 31 Dec 2026 | Viewed by 91 | Submission Open

Keywords: neutrophils; reproductive immunology; NETosis; extracellular traps; fertility; reproductive disorders; endometritis; male infertility; reproductive tract infections; oxidative stress

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapeutic Implications in Cardiovascular Diseases

edited by Luyao Wang

submission deadline 31 Dec 2026 | Viewed by 91 | Submission Open

Keywords: cardiovascular diseases (CVDs); molecular mechanisms; target discovery; therapeutic implications; drug development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond Antimicrobial Resistance: Molecular Mechanisms of Bacterial Survival Strategies and Next-Generation Therapeutic Approaches

edited by

Ksenia Szymanek-Majchrzak

submission deadline 31 Dec 2026 | Viewed by 90 | Submission Open

Keywords: antimicrobial resistance; heteroresistance; persistence; biofilm; bacterial adaptation; antimicrobial tolerance; anti-biofilm therapy; next-generation therapeutics

(This special issue belongs to the Section Molecular Microbiology)

Molecular Design and Characterization of Functional Nanomaterials

edited by Mingyue Zhang

submission deadline 31 Dec 2026 | Viewed by 90 | Submission Open

Keywords: functional nanomaterials; molecular design; nanomaterial synthesis; surface engineering; nanoscale characterization; structure–property relationships; hybrid nanomaterials; chiral nanomaterials; catalytic nanomaterials; energy nanomaterials; carbon-based nanomaterials; quantum dots; biomedical nanomaterials; advanced nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Molecular and Ecophysiological Plant Responses to Environmental Stress

edited by

Md Jahirul Islam

submission deadline 31 Dec 2026 | Viewed by 86 | Submission Open

Keywords: environmental stress; abiotic stress tolerance; plant stress physiology; molecular stress responses; oxidative stress and antioxidants; gene expression and signaling pathways; climate change adaptation in plants; crop resilience and sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Therapeutic Innovations in Hypercholesterolemia and Dyslipidemia

edited by

Baskaran Gunasekaran

submission deadline 31 Dec 2026 | Viewed by 84 | Submission Open

Keywords: hypercholesterolemia; dyslipidemia; cholesterol Metabolism; lipid homeostasis; transcriptomics; nutraceuticals; phytosterols; precision medicine; cardiovascular disease; molecular therapeutic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Complexity of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Bench to Clinical Practice

edited by

Łukasz Bułdak

submission deadline 31 Dec 2026 | Viewed by 79 | Submission Open

Keywords: MASLD; liver steatosis; steatohepatitis; liver cirrhosis; hepatocellular carcinoma; obesity; type 2 diabetes; hyperlipidemia; quality of life; in vivo; in vitro; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Natural Products in Nanotechnology

edited by Mehmet Gokhan Halici

submission deadline 31 Dec 2026 | Viewed by 76 | Submission Open

Keywords: natural products; nanotechnology; green synthesis; biologically mediated nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Hormonal Disturbances in Respiratory Disorders

edited by

Dominika Zając

submission deadline 31 Dec 2026 | Viewed by 71 | Submission Open

Keywords: hormonal disturbances; obesity; diabetes mellitus; hypo-/hyperthyroidism; PCOS; menopause; respiratory diseases; asthma; obstructive sleep apnea (OSA); airway obstruction; airway inflammation; pulmonary arterial hypertension (PAH); recurrent respiratory infections; respiratory failure; allergy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Strategies for Enzyme-Based Biosensors

edited by

Roxana Apetrei

submission deadline 31 Dec 2026 | Viewed by 66 | Submission Open

Keywords: molecular recognition; biocatalysis; biological receptors; nanozymes; molecularly imprinted polymers; transduction interfaces

(This special issue belongs to the Section Macromolecules)

Cholangiocarcinoma: Molecular Diagnosis and Future Therapeutic Perspectives

edited by

Diamantis I. Tsilimigras

and

Ioannis Ntanasis-Stathopoulos

submission deadline 31 Dec 2026 | Viewed by 56 | Submission Open

Keywords: cholangiocarcinoma; molecular diagnostics; precision oncology; biomarkers; targeted therapy; immunotherapy; tumor microenvironment; genomics; liquid biopsy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Sustainable Food and Packaging Systems

edited by

Kingwascharapong Passakorn

submission deadline 1 Jan 2027 | Viewed by 103 | Submission Open

Keywords: molecular food science and molecular interactions; structure–function relationships of food biomolecules; bioactive compounds and functional ingredients; food quality, stability, and functionality; alternative proteins; sustainable processing and circular economy; by-product valorization; biodegradable and active packaging; biomaterials for food and packaging applications; advanced analytical and characterization techniques

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Uncovering the Advantages of Natural Medicines in Treating and Preventing Diseases

edited by

Xingkang Wu

submission deadline 20 Jan 2027 | Viewed by 110 | Submission Open

Keywords: natural medicine; natural product; natural product derivatives; traditional medicine; extract; therapeutic efficacy; toxicological effects; multi-target, multi-pathway

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Insights into Active Substances and Extracts

edited by Diamanto Lazari and

Charikleia Paloukopoulou

submission deadline 20 Jan 2027 | Viewed by 108 | Submission Open

Keywords: bioactive compounds; natural products; synthetic molecules; functional materials; molecular mechanisms; cell signaling; oxidative stress; structure–activity relationships; nutraceuticals; molecular pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Anticancer Agents: Discovery, Development, and Clinical Applications

edited by

Nicoletta Cordani

submission deadline 20 Jan 2027 | Viewed by 91 | Submission Open

Keywords: anticancer agents; targeted therapy; immunotherapy; drug discovery; precision oncology; biomarkers; drug resistance; combination therapy; translational research; clinical applications

(This special issue belongs to the Section Molecular Pharmacology)

Melanoma: Advances in Biology and Treatment

edited by

Joanne Tobacman

submission deadline 20 Jan 2027 | Viewed by 72 | Submission Open

Keywords: chondroitin sulfate; proteoglycans; chondroitin sulfatases; sulfotransferases; microenvironment; checkpoint inhibitor combinations

(This special issue belongs to the Section Molecular Biology)

Nanodelivery Systems in Health and Disease: Molecular Design and Biomedical Applications

edited by

Chi Lin

submission deadline 25 Jan 2027 | Viewed by 109 | Submission Open

Keywords: nanodelivery systems; molecular design; targeted drug delivery; stimuli-responsive nanocarriers; supramolecular assembly; bioactive molecules; nucleic acid delivery; biomedical applications; nutraceutical delivery

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 2301-2350 on page 47 of 62.

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