Insights in Reproductive Immunology: The Immune Regulation at the Maternal-Fetal Interface in Health and Disease

Dear Colleagues,

The maternal–fetal interface represents a unique immunological environment where immune tolerance, inflammation, and tissue remodeling must be tightly coordinated to ensure successful reproduction. Mounting evidence indicates that immune responses play essential roles not only during embryo implantation and pregnancy maintenance but also in the pathogenesis of reproductive disorders affecting both female and male fertility. Simultaneously, emerging technologies are transforming our understanding of reproductive immunology and accelerating the discovery of novel diagnostic and therapeutic strategies.

This Special Issue aims to gather original research articles, reviews, and perspectives addressing recent advances in the field of reproductive immunology in health and disease. The topics of interest include, but are not limited to, the following: uterine immune cells and mechanisms of immune tolerance; extracellular vesicles as mediators of intercellular communication; sperm-induced inflammation and male reproductive immunity; immunometabolism, microbiome, and infection in reproduction; and endometriosis and pregnancy complications. We particularly welcome studies applying innovative approaches, such as single-cell analysis, multi-omics, and integrative technologies, to unravel immune regulation at the maternal–fetal interface and to identify clinical biomarkers or new immunotherapeutic strategies.

Dr. Mariana Cristina Ferrero
Dr. Andrea M. Canellada
Guest Editors

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