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Review

Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke

1
Center of Excellence for Aging and Brain Repair, Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL 33612, USA
2
KM Pharmaceutical Consulting LLC, Washington, DC 20006, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(8), 2845; https://doi.org/10.3390/ijms21082845
Received: 27 March 2020 / Revised: 15 April 2020 / Accepted: 18 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Molecular Research on Neurodegenerative Diseases 2.0)
Human mesenchymal stem cells have been explored for their application in cell-based therapies targeting stroke. Identifying cell lines that stand as safe, accessible, and effective for transplantation, while optimizing dosage, timing, and method of delivery remain critical translational steps towards clinical trials. Preclinical studies using bone marrow-derived NCS-01 cells show the cells’ ability to confer functional recovery in ischemic stroke. Coculturing primary rat cortical cells or human neural progenitor cells with NCS-01 cells protects against oxygen-glucose deprivation. In the rodent middle cerebral artery occlusion model, intracarotid artery administration of NCS-01 cells demonstrate greater efficacy than other mesenchymal stem cells (MSCs) at improving motor and neurological function, as well as reducing infarct volume and peri-infarct cell loss. NCS-01 cells secrete therapeutic factors, including basic fibroblast growth factor and interleukin-6, while also demonstrating a potentially novel mechanism of extending filopodia towards the site of injury. In this review, we discuss recent preclinical advancements using in vitro and in vivo ischemia models that support the transplantation of NCS-01 in human stroke trials. These results, coupled with the recommendations put forth by the consortium of Stem cell Therapeutics as an Emerging Paradigm for Stroke (STEPS), highlight a framework for conducting preclinical research with the ultimate goal of initiating clinical trials. View Full-Text
Keywords: mesenchymal stem cells; cerebral ischemia; middle cerebral artery occlusion; regenerative medicine; interleukin-6; basic fibroblast growth factor; filopodia mesenchymal stem cells; cerebral ischemia; middle cerebral artery occlusion; regenerative medicine; interleukin-6; basic fibroblast growth factor; filopodia
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MDPI and ACS Style

Brown, J.; Park, Y.J.; Lee, J.-Y.; Chase, T.N.; Koga, M.; Borlongan, C.V. Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke. Int. J. Mol. Sci. 2020, 21, 2845. https://doi.org/10.3390/ijms21082845

AMA Style

Brown J, Park YJ, Lee J-Y, Chase TN, Koga M, Borlongan CV. Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke. International Journal of Molecular Sciences. 2020; 21(8):2845. https://doi.org/10.3390/ijms21082845

Chicago/Turabian Style

Brown, John, You J. Park, Jea-Young Lee, Thomas N. Chase, Minako Koga, and Cesar V. Borlongan. 2020. "Bone Marrow-Derived NCS-01 Cells Advance a Novel Cell-Based Therapy for Stroke" International Journal of Molecular Sciences 21, no. 8: 2845. https://doi.org/10.3390/ijms21082845

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