Next Article in Journal
Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late
Next Article in Special Issue
The Role of Midkine in Arteriogenesis, Involving Mechanosensing, Endothelial Cell Proliferation, and Vasodilation
Previous Article in Journal
Genome Sequencing and Carbohydrate-Active Enzyme (CAZyme) Repertoire of the White Rot Fungus Flammulina elastica
Previous Article in Special Issue
Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(8), 2381;

Therapeutic Aspects of Carbon Monoxide in Cardiovascular Disease

Department of Emergency Medicine, Ajou University School of Medicine, Suwon 16499, Korea
Author to whom correspondence should be addressed.
Received: 19 July 2018 / Revised: 8 August 2018 / Accepted: 8 August 2018 / Published: 13 August 2018
Full-Text   |   PDF [431 KB, uploaded 13 August 2018]   |  


Carbon monoxide (CO) is being increasingly recognized as a potential therapeutic with important signaling functions in various diseases. Carbon monoxide-releasing molecules (CORMs) show anti-apoptotic, anti-inflammatory, and anti-oxidant effects on the tissues of organisms, thus contributing to tissue homeostasis. An increase in reactive oxygen species production from the mitochondria after exposure to CO is also considered one of the underlying mechanisms of cardioprotection, although mitochondrial inhibition is the main toxic mechanism of CO poisoning. This review highlights the mechanism of the biological effects of CO and its potential application as a therapeutic in clinical settings, including in cardiovascular diseases. This review also discusses the obstacles and limitations of using exogenous CO or CORMs as a therapeutic option, with respect to acute CO poisoning. View Full-Text
Keywords: carbon monoxide; therapeutics; cardiovascular diseases; adverse effects carbon monoxide; therapeutics; cardiovascular diseases; adverse effects

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kim, H.-H.; Choi, S. Therapeutic Aspects of Carbon Monoxide in Cardiovascular Disease. Int. J. Mol. Sci. 2018, 19, 2381.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top