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Int. J. Mol. Sci. 2019, 20(2), 313; https://doi.org/10.3390/ijms20020313

Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity

1
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
2
Food Science and Technology Program, Department of Chemistry, National University of Singapore, Singapore 117600, Singapore
3
National University of Singapore (Suzhou) Research Institute, Suzhou 215123, China
*
Authors to whom correspondence should be addressed.
Received: 16 December 2018 / Revised: 8 January 2019 / Accepted: 10 January 2019 / Published: 14 January 2019
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Abstract

Though historically known as a toxic gas, hydrogen sulfide (H2S) has displayed a new face as the third endogenous gaseous signaling molecule after nitric oxide (NO) and carbon monoxide (CO). Here in this review, we survey the role and therapeutic potential of H2S in cisplatin-induced nephrotoxicity. Specifically, reduction of H2S by cystathionine γ-lyase (CSE) downregulation upon cisplatin treatment may contribute to cisplatin-induced renal cell injury, possibly by augmentation of endogenous reactive oxygen species (ROS) production, while H2S donation may prevent subsequent renal dysfunction by inhibiting NADPH oxidase activation. Intriguingly, H2S slow-releasing compound GYY4137 seems to increase the anticancer activity of cisplatin, at least in several cancer cell lines, and this is probably due to its own anticancer effect. However, the efficacy of H2S donors in tumor-bearing animals remains to be tested in terms of renal protection and cancer inhibition after receiving cisplatin. Furthermore, accumulative evidence regarding usage of polysulfide, a novel H2S derived molecule, in the therapy of cisplatin-induced nephrotoxicity, was also summarized. View Full-Text
Keywords: hydrogen sulfide; hydrogen polysulfide; cisplatin-induced nephrotoxicity; NADPH oxidase; GYY4137; cystathionine γ-lyase hydrogen sulfide; hydrogen polysulfide; cisplatin-induced nephrotoxicity; NADPH oxidase; GYY4137; cystathionine γ-lyase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cao, X.; Zhang, W.; Moore, P.K.; Bian, J. Protective Smell of Hydrogen Sulfide and Polysulfide in Cisplatin-Induced Nephrotoxicity. Int. J. Mol. Sci. 2019, 20, 313.

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