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Special Issue "Recent Insights in Chemistry and Technology of Cyclodextrins"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editors

Prof. Dr. Antonino Mazzaglia
E-Mail Website
Guest Editor
CNR-ISMN, c/o Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, Viale F. Stagno D'Alcontres 31, I-98166 Messina, Italy
Interests: cyclodextrins; self-assembly; nanodelivery; phototherapeutics; hybrids nanobiomaterials; carbon nanomaterials; nanomedicine; regenerative medicine
Special Issues and Collections in MDPI journals
Dr. Lajos Szente
E-Mail Website
Guest Editor
CycloLab Cyclodextrin Research & Development Laboratory, Ltd., Budapest, Hungary
Interests: industrial uses of cyclodextrins; cyclodextrins as drugs; cyclodextrin antidotes; cellular effects; analytical aspects of cyclodextrins
Prof. Dr. Francesco Trotta
E-Mail Website
Guest Editor

Special Issue Information

Dear Colleagues,

At present, Cyclodextrin Chemistry and Technology has involved numerous scientists in various academic and industrial teams. In this field, pure research and industrial applications mostly converge in the unique aim of improving health and quality of life, increasing the feasibility of green technologies to prepare novel molecules, complexes and innovative materials for nanomedicine, pharmaceutics, cosmetics, food manufacturing, and the environment (bioremediation, renewable energy processes, catalysis, and conservation of cultural heritage). This Special Issue will collect the more meaningful contributions of the ICS2020 symposium (http://www.ismn.cnr.it/ics2020/), and will be focused on the following topics, privileging the property–structure correlation of the designed cyclodextrin systems: 

  • -Chemistry and modeling;
  • -Supramolecules, polymers, and self-assembly;
  • -Nanomaterials;
  • -Hybrid, soft, and biomaterials;
  • -Life science;
  • -Therapy and diagnosis;
  • -Nutraceutics;
  • -Analytical applications;
  • -Green technologies;
  • -Catalysis.

This Special Issue is open from 30 May 2020. Both articles and reviews on the above mentioned topics are fully welcome.

Prof. Dr. Antonino Mazzaglia
Dr. Lajos Szente
Prof. Dr. Francesco Trotta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cyclodextrin
  • Synthesis
  • Modeling
  • Self-assembly
  • Polymers
  • Stimuli-responsive materials
  • Spectroscopic characterization
  • Biomaterials
  • Drug delivery
  • Cell interactions
  • Food chemistry and technology
  • Sensors
  • Green chemistry
  • Catalysis

Published Papers (3 papers)

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Research

Open AccessArticle
Robust Ruthenium Catalysts Supported on Mesoporous Cyclodextrin-Templated TiO2-SiO2 Mixed Oxides for the Hydrogenation of Levulinic Acid to γ-Valerolactone
Int. J. Mol. Sci. 2021, 22(4), 1721; https://doi.org/10.3390/ijms22041721 - 09 Feb 2021
Viewed by 485
Abstract
In this paper, we present a versatile template-directed colloidal self-assembly method for the fabrication in aqueous phase of composition-tuned mesoporous RuO2@TiO2-SiO2 catalysts. Randomly methylated β-cyclodextrin/Pluronic F127 supramolecular assemblies were used as soft templates, TiO2 colloids as building [...] Read more.
In this paper, we present a versatile template-directed colloidal self-assembly method for the fabrication in aqueous phase of composition-tuned mesoporous RuO2@TiO2-SiO2 catalysts. Randomly methylated β-cyclodextrin/Pluronic F127 supramolecular assemblies were used as soft templates, TiO2 colloids as building blocks, and tetraethyl orthosilicate as a silica source. Catalysts were characterized at different stages of their synthesis using dynamic light scattering, N2-adsorption analysis, powder X-ray diffraction, temperature programmed reduction, high-resolution transmission electron microscopy, high-angle annular bright-field and dark-field scanning transmission electron microscopy, together with EDS elemental mapping. Results revealed that both the supramolecular template and the silica loading had a strong impact on the pore characteristics and crystalline structure of the mixed oxides, as well as on the morphology of the RuO2 nanocrystals. Their catalytic performance was then evaluated in the aqueous phase hydrogenation of levulinic acid (LA) to γ-valerolactone (GVL) under mild conditions (50 °C, 50 bar H2). Results showed that the cyclodextrin-derived catalyst displayed almost quantitative LA conversion and 99% GVL yield in less than one hour. Moreover, this catalyst could be reused at least five times without loss of activity. This work offers an effective approach to the utilization of cyclodextrins for engineering the surface morphology of Ru nanocrystals and pore characteristics of TiO2-based materials for catalytic applications in hydrogenation reactions. Full article
(This article belongs to the Special Issue Recent Insights in Chemistry and Technology of Cyclodextrins)
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Open AccessArticle
Controlled Drug Release and Cytotoxicity Studies of Beta-Lapachone and Doxorubicin Loaded into Cyclodextrins Attached to a Polyethyleneimine Matrix
Int. J. Mol. Sci. 2020, 21(16), 5832; https://doi.org/10.3390/ijms21165832 - 14 Aug 2020
Viewed by 677
Abstract
This work presents a new look at the application of cyclodextrins (CD) as a drug nanocarrier. Two different cyclodextrins (αCD, βCD) were covalently conjugated to branched polyethylenimine (PEI), which was additionally functionalized with folic acid (PEI-βCD-αCD-FA). [...] Read more.
This work presents a new look at the application of cyclodextrins (CD) as a drug nanocarrier. Two different cyclodextrins (αCD, βCD) were covalently conjugated to branched polyethylenimine (PEI), which was additionally functionalized with folic acid (PEI-βCD-αCD-FA). Here, we demonstrated that the combination of αCD and βCD enabled to load and control release of two anticancer drugs: doxorubicin (DOX) and beta-lapachone (beta-LP) (DOX in β-CD and beta-LP into α-CD) via host-guest inclusion. The PEI-βCD(DOX)-αCD-FA nanoconjugate was used to transport anticancer drugs into A549 lung cancer cells for estimation the cytotoxic and antitumor effect of this nanoconjugate. The presence of FA molecules should facilitate the penetration of studied nanoconjugate into the cell. Whereas, the non-cellular experiments proved that the drugs are released from the carrier mainly in the pH 4.0. The release mechanism is found to be anomalous in all studied cases. Full article
(This article belongs to the Special Issue Recent Insights in Chemistry and Technology of Cyclodextrins)
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Open AccessArticle
Intracellular Fate and Impact on Gene Expression of Doxorubicin/Cyclodextrin-Graphene Nanomaterials at Sub-Toxic Concentration
Int. J. Mol. Sci. 2020, 21(14), 4891; https://doi.org/10.3390/ijms21144891 - 10 Jul 2020
Cited by 5 | Viewed by 758
Abstract
The graphene road in nanomedicine still seems very long and winding because the current knowledge about graphene/cell interactions and the safety issues are not yet sufficiently clarified. Specifically, the impact of graphene exposure on gene expression is a largely unexplored concern. Herein, we [...] Read more.
The graphene road in nanomedicine still seems very long and winding because the current knowledge about graphene/cell interactions and the safety issues are not yet sufficiently clarified. Specifically, the impact of graphene exposure on gene expression is a largely unexplored concern. Herein, we investigated the intracellular fate of graphene (G) decorated with cyclodextrins (CD) and loaded with doxorubicin (DOX) and the modulation of genes involved in cancer-associated canonical pathways. Intracellular fate of [email protected], tracked by FLIM, Raman mapping and fluorescence microscopy, evidenced the efficient cellular uptake of [email protected] and the presence of DOX in the nucleus, without graphene carrier. The NanoString nCounter™ platform provided evidence for 34 (out of 700) differentially expressed cancer-related genes in HEp-2 cells treated with [email protected] (25 µg/mL) compared with untreated cells. Cells treated with GCD alone (25 µg/mL) showed modification for 16 genes. Overall, 14 common genes were differentially expressed in both GCD and [email protected] treated cells and 4 of these genes with an opposite trend. The modification of cancer related genes also at sub-cytotoxic G concentration should be taken in consideration for the rational design of safe and effective G-based drug/gene delivery systems. The reliable advantages provided by NanoString® technology, such as sensibility and the direct RNA measurements, could be the cornerstone in this field. Full article
(This article belongs to the Special Issue Recent Insights in Chemistry and Technology of Cyclodextrins)
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