cGMP-Signalling in Cells: Molecular and Functional Features

Dear Colleagues,

Cellular signalling by cGMP is an expanding field which comprises molecular function and (patho)physiology in various organ systems. cGMP synthesis, degradation and function are modulated by a variety of signalling proteins and signal transduction pathways. Stuctural, biochemical and (patho)physiological aspects have been strongly developed in the last decade, e.g., regarding cardiovascular, renal, pulmonary and neuronal function. Dysregulation of cGMP generators (guanylyl cyclases), modulators (phosphodiesterases) and signalling molecules (e.g., kinases/substrates, channels) have been elucidated as cause of pathophysiological processes and diseases. Pharmacological approaches have been propagated into pharmacological treatments including hypertension and cardiovascular diseases. Therefore, the molecular and functional understanding of the diverse cGMP generators, signalling proteins and signal transduction pathways is fundamental for the insight into their (patho)physiological processes. The scope of the Special Issue is to summarize and enlarge the knowledge of these signalling processes and networks in diverse cells/tissues and to link it to (patho)physiological and pharmacological functions.

Therefore, authors are invited to submit original research and review articles which address the progress and current standing of cGMP signalling.

Topics include, but are not limited to:

• Identification of and new molecular and functional aspects in cGMP-signalling molecules and pathways
• Analysis of cGMP-signal generation, modulation, recognition and/or its transduction into physiological/pathophysiological responses
• Techniques for the analysis and identification of cGMP signalling molecules, complexes, pathways and networks

Prof. Dr. Jens Schlossmann
Guest Editor

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