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Int. J. Mol. Sci. 2018, 19(3), 801;

cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging

Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg 20246, Germany
German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Hamburg 20246, Germany
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 1 March 2018 / Accepted: 7 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue cGMP-Signalling in Cells: Molecular and Functional Features)
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The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system. View Full-Text
Keywords: cGMP; cardiovascular system; imaging; FRET; compartmentation cGMP; cardiovascular system; imaging; FRET; compartmentation

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Bork, N.I.; Nikolaev, V.O. cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging. Int. J. Mol. Sci. 2018, 19, 801.

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