Int. J. Mol. Sci. 2018, 19(3), 801; https://doi.org/10.3390/ijms19030801
cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging
1
Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg 20246, Germany
2
German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Hamburg 20246, Germany
*
Author to whom correspondence should be addressed.
Received: 31 January 2018 / Revised: 1 March 2018 / Accepted: 7 March 2018 / Published: 10 March 2018
(This article belongs to the Special Issue cGMP-Signalling in Cells: Molecular and Functional Features)
Abstract
The ubiquitous second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system. View Full-TextKeywords:
cGMP; cardiovascular system; imaging; FRET; compartmentation
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Bork, N.I.; Nikolaev, V.O. cGMP Signaling in the Cardiovascular System—The Role of Compartmentation and Its Live Cell Imaging. Int. J. Mol. Sci. 2018, 19, 801.
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