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Open AccessArticle

Two Different Strategies to Enhance Osseointegration in Porous Titanium: Inorganic Thermo-Chemical Treatment Versus Organic Coating by Peptide Adsorption

1
Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Metallurgical Engineering, Universitat Politècnica de Catalunya (UPC), 08019 Barcelona, Spain
2
Barcelona Research Center in Multiscale Science and Engineering, Universitat Politècnica de Catalunya (UPC), 08019 Barcelona, Spain
3
Departamento de Cirugía Animal, Facultad de Veterinaria, Universidad Autónoma de Barcelona, Bellaterra, 08193 Barcelona, Spain
4
Facultad de Odontología, Campus de Medicina y Ciencias de la Salud, Universidad Internacional de Cataluña (UIC), 08017 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2574; https://doi.org/10.3390/ijms19092574
Received: 21 July 2018 / Revised: 8 August 2018 / Accepted: 25 August 2018 / Published: 30 August 2018
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering)
In this study, highly-interconnected porous titanium implants were produced by powder sintering with different porous diameters and open interconnectivity. The actual foams were produced using high cost technologies: Chemical Vapor Deposition (CVD), Physical Vapor Deposition (PVD), and spark plasma sintering, and the porosity and/or interconnection was not optimized. The aim was to generate a bioactive surface on foams using two different strategies, based on inorganic thermo-chemical treatment and organic coating by peptide adsorption, to enhance osseointegration. Porosity was produced using NaCl as a space holder and polyethyleneglicol as a binder phase. Static and fatigue tests were performed in order to determine mechanical behaviors. Surface bioactivation was performed using a thermo-chemical treatment or by chemical adsorption with peptides. Osteoblast-like cells were cultured and cytotoxicity was measured. Bioactivated scaffolds and a control were implanted in the tibiae of rabbits. Histomorphometric evaluation was performed at 4 weeks after implantation. Interconnected porosity was 53% with an average diameter of 210 µm and an elastic modulus of around 1 GPa with good mechanical properties. The samples presented cell survival values close to 100% of viability. Newly formed bone was observed inside macropores, through interconnected porosity, and on the implant surface. Successful bone colonization of inner structure (40%) suggested good osteoconductive capability of the implant. Bioactivated foams showed better results than non-treated ones, suggesting both bioactivation strategies induce osteointegration capability. View Full-Text
Keywords: titanium foams; osseointegration; porosity; bioactive materials titanium foams; osseointegration; porosity; bioactive materials
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MDPI and ACS Style

Ortiz-Hernandez, M.; Rappe, K.S.; Molmeneu, M.; Mas-Moruno, C.; Guillem-Marti, J.; Punset, M.; Caparros, C.; Calero, J.; Franch, J.; Fernandez-Fairen, M.; Gil, J. Two Different Strategies to Enhance Osseointegration in Porous Titanium: Inorganic Thermo-Chemical Treatment Versus Organic Coating by Peptide Adsorption. Int. J. Mol. Sci. 2018, 19, 2574. https://doi.org/10.3390/ijms19092574

AMA Style

Ortiz-Hernandez M, Rappe KS, Molmeneu M, Mas-Moruno C, Guillem-Marti J, Punset M, Caparros C, Calero J, Franch J, Fernandez-Fairen M, Gil J. Two Different Strategies to Enhance Osseointegration in Porous Titanium: Inorganic Thermo-Chemical Treatment Versus Organic Coating by Peptide Adsorption. International Journal of Molecular Sciences. 2018; 19(9):2574. https://doi.org/10.3390/ijms19092574

Chicago/Turabian Style

Ortiz-Hernandez, Monica; Rappe, Katrin S.; Molmeneu, Meritxell; Mas-Moruno, Carles; Guillem-Marti, Jordi; Punset, Miquel; Caparros, Cristina; Calero, Jose; Franch, Jordi; Fernandez-Fairen, Mariano; Gil, Javier. 2018. "Two Different Strategies to Enhance Osseointegration in Porous Titanium: Inorganic Thermo-Chemical Treatment Versus Organic Coating by Peptide Adsorption" Int. J. Mol. Sci. 19, no. 9: 2574. https://doi.org/10.3390/ijms19092574

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