Systemic Lupus Erythematosus: Research Updates in Immunopathogenesis, Biomarkers and Therapeutics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 64595
Special Issue Editors
Interests: role of dendritic cells in SLE pathogenesis; molecular regulatory mechanisms of dendritic cell functions; mechanistic studies of cellular immuno-dysregulation in SLE; evaluation of the clinical outcome of SLE
Special Issues, Collections and Topics in MDPI journals
Interests: C-type lectin receptors immunobiology and its role in autoimmune diseases and infection; cellular and molecular dysregulation in SLE; immuno-therapeutics development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations involving multiple organ systems. Clinically, SLE is still mainly managed by the use of conventional immunosuppressants and steroids with undesirable side-effects; the efficacies of new biologics are yet to be substantiated. Thus, understanding SLE pathogenic mechanisms is of imminent importance to advancing the management of this condition. SLE pathogenesis is highly intricate and etiologically contributed by a combination of multiple genetic and environmental elements. SLE is characterized by the loss of tolerance to self-antigens, dysregulated autoreactive T- and B-cell activation, the production of autoantibodies, and perturbed cytokine activities. In the past decade, advances in next-generation genomics technology have revealed many molecular targets that, as substantiated by many cellular and in vivo animal studies, can be further explored as potential therapeutics. In addition, new cellular players that contribute to disease progression and perpetuation have also been unveiled. This Special Issue aims to provide recent research highlights that focus on understanding the immuno-pathogenesis mechanisms, biomarkers, and novel therapeutics development in SLE. Topics include, but are not limited to, the following:
- The genetics of lupus
- The epigenetic regulation of lupus
- Cellular and molecular dysregulation in SLE
- Cytokine perturbation and contribution to lupus progression
- Innate and adaptive immunity in SLE
- Immuno-regulatory cells in lupus
- Biomarker development for prognosis and monitoring lupus disease
- Novel therapeutics and new treatment strategies for lupus
Prof. Dr. Chak-Sing Lau
Dr. Vera Sau-Fong Chan
Guest Editors
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Keywords
- Lupus
- Autoimmunity
- Cytokines
- Epigenetics
- Innate immunity
- Genetics
- Immunoregulation
- Biomarkers
- Therapeutics
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