Therapeutic Strategies and Targets for Reactive Oxygen Species Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 24454
Special Issue Editors
Interests: nanomedicine; tumor-targeting; EPR effect; carbon monoxide; inflammation; reactive oxygen species
Special Issues, Collections and Topics in MDPI journals
Interests: Oxidative stress; redox signaling; Nitric oxide persulfide and sulfur metabolism; inflammation; infectious diseases
Special Issue Information
Dear Colleagues,
Oxidative stress, and namely over-production of ROS, involves in the initiation and progression of many diseases and disorders, including cardiovascular diseases, inflammation, ischemia–reperfusion (I/R) injury, viral pathogenesis, drug-induced tissue injury, hypertension, formation of drug resistant mutant, as well as cancer. Thus, it is essential to counterbalance ROS and to treat such ROS-related diseases by inhibiting ROS production. This aim could be achieved by focusing on the antioxidative defence systems including superoxide dismutase (SOD), catalase, glutathione peroxidase, and heme oxygenase-1 (HO-1), as well as using antioxidants ascorbate, tocopherol, glutathione, and more recently discovered persulfides/polysulfides (RSS). On the contrary, due to their highly cytotoxic nature, ROS can also be used to kill cancer cells if their generation can be selectively modulated in cancer. Generation of ROS is the major anticancer mechanism of many anticancer drugs such as doxorubicin, camptothecin, cisplatin, etc. Targeted delivery ROS to a tumor is a promising anticancer approach. This Special Issue focuses on the therapeutic strategies and potential target molecules for the treatment of ROS-related diseases.
Dr. Jun Fang
Prof. Dr. Tomohiro Sawa
Guest Editors
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