Therapeutic Strategies and Targets for Reactive Oxygen Species Related Diseases

Dear Colleagues,

Oxidative stress, and namely over-production of ROS, involves in the initiation and progression of many diseases and disorders, including cardiovascular diseases, inflammation, ischemia–reperfusion (I/R) injury, viral pathogenesis, drug-induced tissue injury, hypertension, formation of drug resistant mutant, as well as cancer. Thus, it is essential to counterbalance ROS and to treat such ROS-related diseases by inhibiting ROS production. This aim could be achieved by focusing on the antioxidative defence systems including superoxide dismutase (SOD), catalase, glutathione peroxidase, and heme oxygenase-1 (HO-1), as well as using antioxidants ascorbate, tocopherol, glutathione, and more recently discovered persulfides/polysulfides (RSS). On the contrary, due to their highly cytotoxic nature, ROS can also be used to kill cancer cells if their generation can be selectively modulated in cancer. Generation of ROS is the major anticancer mechanism of many anticancer drugs such as doxorubicin, camptothecin, cisplatin, etc. Targeted delivery ROS to a tumor is a promising anticancer approach. This Special Issue focuses on the therapeutic strategies and potential target molecules for the treatment of ROS-related diseases.

Dr. Jun Fang
Prof. Dr. Tomohiro Sawa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.