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Natural Products and Oral Health: Challenges and Opportunities

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 940

Special Issue Editors


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Guest Editor
REQUIMTE/UCIBIO, MedTech-Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira nº. 228, 4050-313 Porto, Portugal
Interests: encapsulation; drug delivery systems; modified drug delivery; pharmaceutics

Special Issue Information

Dear Colleagues,

Oral diseases encompass a range of diseases and conditions that include periodontal (gum) disease, oral mucositis (OM), oral cancer, etc., which are among the most common noncommunicable diseases worldwide. The use of bioactive compounds extracted from natural sources with biological properties is an interesting approach to prevent/treat oral diseases and their related complications, such as OM.

Recently, attention has been paid to polyphenols and their positive effects against oral diseases in human trials, due to their antioxidant, anti-inflammatory, or anti-proliferative activities.

Therefore, the use of bioactive compounds extracted from natural sources with biological properties may be an approach to prevent/treat oral diseases and, most importantly, discover new potential compounds. Importantly, targeting metabolic, oxidative stress, and mitochondrial pathways could provide disease-selective natural compounds.

However, the orally absorbed bioactive compound concentration is often low, avoiding an acceptable therapeutic effect. Other drawbacks regarding the pharmacokinetics (PK) profile or stability across the gastrointestinal tract (GIT) may occur. Encapsulation could be a strategy to prevent such problems and improve buccal delivery.

This Special Issue of IJMS invites research articles, reviews, and opinion reviews on fascinating advancements in the area of the efficacy of natural compounds for oral diseases and their related complications.

Dr. Francisca Rodrigues
Dr. Paulo Cardoso Da Costa
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • phytochemicals
  • natural compounds 
  • antitumor activity
  • oral mucositis
  • encapsulation 
  • drug delivery systems 
  • oxidative stress
  • metabolic pathways 
  • protein expression
  • cellular signaling 
  • cancer prevention 
  • immunomodulation 
  • adjuvant therapy
  • preventive therapy

Published Papers (1 paper)

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Research

16 pages, 1671 KiB  
Article
Clinical Effect of Thioglycosides Extracted from White Mustard on Dental Plaque and Gingivitis: Randomized, Single-Blinded Clinical Trial
by Konrad Michałowski and Aniela Brodzikowska
Int. J. Mol. Sci. 2024, 25(10), 5290; https://doi.org/10.3390/ijms25105290 - 13 May 2024
Viewed by 417
Abstract
The antibacterial and anti-inflammatory effect of thioglycosides has already been established. This study investigates the effects of thioglycosides extracted from white mustard, specifically the “Bamberka” variety, in the context of oral hygiene. The aim of the study is to clarify an evidence-based link [...] Read more.
The antibacterial and anti-inflammatory effect of thioglycosides has already been established. This study investigates the effects of thioglycosides extracted from white mustard, specifically the “Bamberka” variety, in the context of oral hygiene. The aim of the study is to clarify an evidence-based link between the documented antibacterial and anti-inflammatory effects attributed to thioglycosides and their practical application in oral care. A randomized, single-blinded (patient-blinded) clinical study was performed on 66 patients using mustard-based toothpaste for oral hygiene. The patients were examined at baseline and after 6 and 12 months. The values of the Approximal Plaque Index (API), the Plaque Index (PI), and Bleeding on probing (BOP) were taken into consideration. The results show a significant reduction in plaque accumulation, especially after 6 months of using mustard-based toothpaste in all examined parameters. This suggests that thioglycosides from mustard contribute to a considerable decrease in dental plaque accumulation, confirming their potential in natural oral care solutions, which is indicated in the main conclusions or interpretations. Full article
(This article belongs to the Special Issue Natural Products and Oral Health: Challenges and Opportunities)
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