Human and Animal Monocytes and Macrophages in Homeostasis and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 45285
Special Issue Editors
Interests: macrophages; actin cytoskeleton; RhoA pathway; chronic rejection; transplantation; germ cells; stem cells; Xenopus laevis; development
Special Issues, Collections and Topics in MDPI journals
Interests: embryo development; cell cycle; gene regulation; cancer; stem cells; gonads; genetic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Monocytes and macrophages play fundamental roles in organisms’ homeostasis and inflammatory processes, in both physiological and pathological situations. Tissue-resident macrophages participate in tissue/organ renewal, and by changing their microbicidal properties, they accommodate organism microbiota. In SARS-CoV-2 infection, monocytes and alveolar macrophages are involved in the development of the acute respiratory distress syndrome (ARDS) through the exacerbated secretion of pro-inflammatory factors. The management of this macrophage-derived cytokine storm is of paramount importance during the current COVID-19 pandemic. Another burning issue in which monocytes and macrophages play important roles is diabetes mellitus and the inflammatory processes involved in its etiology. The specialized subpopulation of macrophages, tumor-associated macrophages (TAMs), plays a role in the development and metastasis of cancer. Monocytes and macrophages are also responsible for the chronic rejection and long-term failure of transplanted organs. The efficient fight against these scourges requires a better understanding of the molecular and cellular mechanisms allowing monocytes and macrophages to underreact or overreact in their homeostatic and/or pathogen fighting roles. For this Special Issue, we invite research and review articles on recent progress in physiology and pathology linked to human and animal monocyte and macrophage functions in homeostasis and diseases.
Prof. Dr. Malgorzata Kloc
Prof. Dr. Jacek Z Kubiak
Guest Editors
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Keywords
- monocytes
- macrophages
- inflammation
- diseases
- COVID-19
- diabetes mellitus
- polarity
- phagocytosis
- cytokine secretion
- chemotaxis
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