Next Article in Journal
Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease
Next Article in Special Issue
The Unique Phenotype of Lipid-Laden Macrophages
Previous Article in Journal
The PI3Kδ Inhibitor Idelalisib Diminishes Platelet Function and Shows Antithrombotic Potential
Previous Article in Special Issue
Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages
 
 
Review

Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease

by 1,2, 1,2,3 and 2,3,4,5,*
1
Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany
2
REBIRTH Research Center for Translational and Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany
3
Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, 30625 Hannover, Germany
4
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany
5
Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Malgorzata Kloc and Jacek Z Kubiak
Int. J. Mol. Sci. 2021, 22(7), 3308; https://doi.org/10.3390/ijms22073308
Received: 24 February 2021 / Revised: 19 March 2021 / Accepted: 20 March 2021 / Published: 24 March 2021
Macrophages act as immune scavengers and are important cell types in the homeostasis of various tissues. Given the multiple roles of macrophages, these cells can also be found as tissue resident macrophages tightly integrated into a variety of tissues in which they fulfill crucial and organ-specific functions. The lung harbors at least two macrophage populations: interstitial and alveolar macrophages, which occupy different niches and functions. In this review, we provide the latest insights into the multiple roles of alveolar macrophages while unraveling the distinct factors which can influence the ontogeny and function of these cells. Furthermore, we will highlight pulmonary diseases, which are associated with dysfunctional macrophages, concentrating on congenital diseases as well as pulmonary infections and impairment of immunological pathways. Moreover, we will provide an overview about different treatment approaches targeting macrophage dysfunction. Improved knowledge of the role of macrophages in the onset of pulmonary diseases may provide the basis for new pharmacological and/or cell-based immunotherapies and will extend our understanding to other macrophage-related disorders. View Full-Text
Keywords: alveolar macrophage; surfactant; pulmonary infections; asthma; fibrosis; tolerogenic potential; pulmonary alveolar proteinosis; monocytes alveolar macrophage; surfactant; pulmonary infections; asthma; fibrosis; tolerogenic potential; pulmonary alveolar proteinosis; monocytes
Show Figures

Figure 1

MDPI and ACS Style

Hetzel, M.; Ackermann, M.; Lachmann, N. Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease. Int. J. Mol. Sci. 2021, 22, 3308. https://doi.org/10.3390/ijms22073308

AMA Style

Hetzel M, Ackermann M, Lachmann N. Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease. International Journal of Molecular Sciences. 2021; 22(7):3308. https://doi.org/10.3390/ijms22073308

Chicago/Turabian Style

Hetzel, Miriam, Mania Ackermann, and Nico Lachmann. 2021. "Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease" International Journal of Molecular Sciences 22, no. 7: 3308. https://doi.org/10.3390/ijms22073308

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop