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Special Issue "Extracellular Vesicles as a New Source of Liquid Biopsy"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 15 November 2020.

Special Issue Editor

Dr. Paola Lanuti
Guest Editor
Department of Medicine and Aging Science, University “G. d’Annunzio” of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy
Interests: extracellular vesicles; flow cytometry; biomarkers

Special Issue Information

Dear colleagues,

Within the past decade, extracellular vesicles have progressively emerged as key regulators of organized communities of cells within multicellular organisms in health and disease. Extracellular vesicles have been described as shuttle vectors or signal transducers that can deliver specific biological information even at long distances. Due to their substantial stability, extracellular vesicles circulate through bodily fluids and have been identified in blood, urine, cerebrospinal fluid, saliva, milk, and tears. It is known that extracellular vesicles are a heterogeneous group of lipidic structures ranging from 30–50,000 nm in size, generically subclassified as small, if within 100 nm, and medium/large, if above 100–200 nm.

The extracellular vesicle cargo, consisting of genomic DNA, RNAs, miRNAs, proteins, and lipids dynamically reflecting the characteristics of the cells of origin, makes them an attractive source of biological information. For all of these reasons, extracellular vesicles have high potential as dynamic biomarkers of diseases and/or response to therapies. The deep characterization of extracellular vesicle general characteristics and cargoes related to their roles in tumorigenesis, immunity, and vascular biology may present interesting perspectives in the assessment of extracellular vesicles as a reliable liquid biopsy source.

Dr. Paola Lanuti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Exosomes
  • Microvesicles
  • Apoptotic bodies
  • Large oncosomes
  • Extracellular vesicles
  • Biomarkers
  • Liquid biopsy
  • Intercellular communication
  • Cancer

Published Papers (1 paper)

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Open AccessArticle
Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study
Int. J. Mol. Sci. 2020, 21(13), 4624; https://doi.org/10.3390/ijms21134624 - 29 Jun 2020
The tumor microenvironment has gained a lot of attention from the scientific community since it has a proven impact in the development of tumor progression and metastasis. Extracellular vesicles (EVs) are now considered one of the key players of tumor microenvironment modulation. Clear [...] Read more.
The tumor microenvironment has gained a lot of attention from the scientific community since it has a proven impact in the development of tumor progression and metastasis. Extracellular vesicles (EVs) are now considered one of the key players of tumor microenvironment modulation. Clear cell renal cell carcinoma (ccRCC) is the most lethal urological neoplasia and presents a high metastatic potential, which reinforces the need for the development of more effective predictive biomarkers. Our goal was to evaluate the applicability of EV-derived matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) as prognostic biomarkers for ccRCC. To do so, we studied the plasma EV content of 32 patients with localized ccRCC and 29 patients with metastatic ccRCC. We observed that patients with localized disease and tumors larger than 7 cm presented higher levels of plasma EV-derived TIMP-1 mRNA when compared with patients presenting smaller tumors (p = 0.020). Moreover, patients with metastatic disease presented higher levels of EV-derived TIMP-1 mRNA when compared with patients with localized disease (p = 0.002) and when we stratified those patients in high and low levels of TIMP-1 EV-derived mRNA, the ones presenting higher levels had a lower overall survival (p = 0.030). EV-derived TIMP-1 mRNA may be a good prognostic biomarker candidate for ccRCC. Full article
(This article belongs to the Special Issue Extracellular Vesicles as a New Source of Liquid Biopsy)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Extracellular vesicle components in liquid biopsies for lung diseases

Title: MiR-365 (microRNA): Potential Biomarker In Oral Squamous Cell Carcinoma Exosomes

Title: Placental Exosomes Revisited

Title: Exosomal RNA of Melanoma Origin Contain Pro-metastasis miRNA and lncRNA

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