Therapeutic Applications and Biology of Extracellular Vesicles

Dear Colleagues,

Extracellular vesicles (EVs) have emerged as key players in complex multicellular organism communication networks. These nano-sized particles, lipid-enveloped structures, secreted by virtually all cell types, transport many bioactive molecules, such as nucleic acids, proteins, and lipids, reflecting the cargo of their parental cells. EVs have been involved in a wide range of biological processes, from immune modulation to angiogenesis and tumorigenesis, prompting innovative strategies to harness their potential as diagnostic biomarkers and therapeutic delivery systems.

Their ability to cross biological barriers, biocompatibility, and low immunogenicity highlight EVs as new vehicles for targeted therapies. Engineered EVs have been proposed to increase drug accumulation at tumour sites and overcome resistance mechanisms, demonstrating great potential in precision medicine. Likewise, EVs derived from mesenchymal stem cells are employed in research in regenerative medicine due to their immunomodulatory properties and tissue repair-promoting capability.

This Special Issue delves into the biology of EVs and their potential therapeutic applications, presenting cutting-edge research that underlines their great potential in medicine. By examining these aspects, we aim to inspire and explore novel strategies to harness EVs both as a potential diagnostic tool and as an innovative method for therapeutic applications.

Dr. Paola Lanuti
Prof. Dr. Francesco Cappello
Dr. Celeste Caruso Bavisotto
Guest Editors

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