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Anti-Inflammatory Diet and Chronic Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 1123

Special Issue Editors


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Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95124 Catania, Italy
Interests: immunology; degenerative diseases; nutrients
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95124 Catania, Italy
Interests: physiopathology; immunology; micronutrients
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Low-grade chronic inflammation triggers unequivocal reactions and the manifestation of various chronic diseases including renal, respiratory, cardio-, and neuro-vascular diseases, as well as muscular and osteo-articular degeneration. Since nutrients influence microbiota and components of the immune system, the essential principle of an anti-inflammatory diet is to induce the production of molecules that counteract oxidative stress and pro-inflammatory factors. Currently, multiple studies indicate that vegetables, fruits, and other natural sources rich in bioactive compounds such as vitamins, polyphenols, flavonoids, tannins, and terpenoids are able to modulate inflammatory pathways through a wide range of biological functions and consequently mitigate the development and progression of chronic diseases.

This Special Issue, entitled Anti-inflammatory Diet and Chronic Disease, aims to present high-quality research that explores mechanistic processes and the effects of nutritional status, dietary patterns, and food bioactivities on systemic inflammation, immune cell populations, and lymphoid tissues, as well as their associations with the pathogenesis of infectious and chronic diseases. The in-depth study of interactions between natural compounds and inflammatory processes is fundamental in promoting integrated food advice for the effective achievement of new preventive and therapeutic strategies.

Prof. Dr. Lucia Malaguarnera
Dr. Cristina Russo
Guest Editors

Manuscript Submission Information

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Keywords

  • inflammation
  • nutrients
  • bioactive molecules
  • immuno-response
  • oxidative stress
  • microbiota
  • chronic disease

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Published Papers (1 paper)

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Review

15 pages, 689 KB  
Review
The Role of Zinc in Pediatric Asthma and Allergic Rhinitis: Mechanisms and Clinical Implications
by Giulio Dinardo, Cristiana Indolfi, Angela Klain, Carolina Grella, Maria Angela Tosca, Eleonora Ruocco, Michele Miraglia del Giudice and Giorgio Ciprandi
Nutrients 2025, 17(16), 2660; https://doi.org/10.3390/nu17162660 - 17 Aug 2025
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Abstract
Pediatric asthma and allergic rhinitis are prevalent chronic inflammatory diseases ruled by complex interactions among genetic, environmental, and nutritional factors. Zinc, an essential trace element, plays a crucial role in immune modulation, oxidative stress regulation, and epithelial barrier maintenance, all of which are [...] Read more.
Pediatric asthma and allergic rhinitis are prevalent chronic inflammatory diseases ruled by complex interactions among genetic, environmental, and nutritional factors. Zinc, an essential trace element, plays a crucial role in immune modulation, oxidative stress regulation, and epithelial barrier maintenance, all of which are significant in the context of allergic airway diseases. This review aimed to explore and synthesize current evidence on the biological mechanisms and clinical implications of zinc in pediatric asthma and allergic rhinitis. A comprehensive literature search was conducted through PubMed and the Cochrane Library for studies published between 2015 and 2025. Eligible studies included observational and interventional research focused on zinc status or supplementation in children with asthma or allergic rhinitis. Numerous observational studies and meta-analyses indicated reduced circulating zinc levels in children with asthma, often correlating with poor symptom control, increased oxidative stress, and lower pulmonary function. In allergic rhinitis, zinc depletion in nasal mucosa was associated with elevated local inflammation, although paradoxical increases in zinc concentrations have been observed in nasal secretions during active disease. Interventional trials in pediatric asthma populations showed that zinc supplementation may improve clinical symptoms, reduce inflammation, and enhance lung function, although the results were inconsistent and limited by methodological variability. In conclusion, zinc plays a multifactorial role in modulating immune responses and maintaining mucosal health in pediatric allergic airway diseases. While zinc supplementation holds promise as a safe and accessible adjunctive therapy, further high-quality randomized controlled trials are needed to define its clinical utility and establish evidence-based guidelines. Full article
(This article belongs to the Special Issue Anti-Inflammatory Diet and Chronic Disease)
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