Special Issue "Chemokines in Cancer and Inflammatory Diseases"
Deadline for manuscript submissions: closed (30 April 2019).
Interests: chemokines; posttranslational modification; chemokine-glycosaminoglycan interactions; chemokine signaling properties; chemokines in disease
Interests: inflammation; arthritis; chemokines; pain; resolution of inflammation
Chemokines are critical mediators during homeostatic and pathological conditions, controlling cellular proliferation, differentiation, movement, and activation. The chemokine biology is a complex system that is regulated at multiple levels including ligand and receptor expression in tissues, interaction with glycosaminoglycans, biased signaling through G protein-coupled receptors, synergy between chemoattractants and posttranslational modifications of chemokines and chemokine receptors. In an inflammatory environment, chemokines have a major function in controlling leukocyte migration in the productive and the resolving phases of inflammation. Besides their active participation in acute and chronic inflammatory disorders, some chemokine have angiogenic or fibrotic properties. In addition, in cancer immunity, chemokines shape the tumor microenvironment by controlling the accumulation of different cellular populations that impact on tumor progression. Therefore, detailed knowledge on the activity of the chemokine system during pathological situations is essential for the development of new strategies to treat diseases targeting this chemokine system. Here, we invite authors to submit studies on the role of chemokines in homeostasis, inflammation or cancer.Prof. Dr. Paul Proost
Prof. Dr. Flavio A. Amaral
Manuscript Submission Information
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