The Involvement of Cholinergic and Norepinephrine Network Modulation in Alzheimer’s Disease Cognitive Dysfunction

Dear Colleagues,

Some people can tolerate more Alzheimer’s-related pathological change, senile plagues, and neurofibrillary tangles than others, due to having a “cognitive reserve.” In individuals with cognitive reserve, the functional network connection in the cerebral cortex can be visualized as intact using functional Magnetic Resonance Imaging. However, the details of the molecular mechanism underlying the prevention of cognitive impairment in the presence of AD-related pathology are still unknown. Interestingly, the cholinergic and/or adrenergic neural signaling may modulate hippocampal glutamatergic neural activity under the AD-related pathology. In this Special Issue, we are seeking novel research and/or review articles on:

• The pathological condition and cognitive dysfunction
• The advancement of AD model animal from a standpoint of neural network
• Neurophysiological network and/or modulation
• Prevention of impairment in cognition/neural network under AD-related pathology
• Functional Magnetic Resonance Imaging and neural network

In this issue, we are looking for articles clearly articulating the molecular and/or physiological mechanism underlying cognitive reserve in patients with AD-related pathology.

Dr. Noriyuki Matsukawa
Dr. Daisuke Kato
Guest Editors

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