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Special Issue "The Microbiota-Gut-Brain Axis in Relation to Non-communicable Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2022 | Viewed by 368

Special Issue Editors

Dr. Diego A. Moreno
E-Mail Website
Guest Editor
1. Phytochemistry and Healthy Foods Laboratory, Department of Food Science and Technology, National Council for Scientific Research (CEBAS-CSIC), Murcia, Spain
2. Associated Unit of R&D and Innovation CEBAS-CSIC+UPCT on “Quality and Risk Assessment of Foods”, CEBAS-CSIC, Campus Espinardo - 25, E-30100 Murcia, Spain
Interests: food science and technology; phytochemistry; bioactive compounds; health-promoters, functional ingredients; natural foods; healthy foods; energy metabolism (obesity and diabetes); human nutrition; wellbeing
Special Issues, Collections and Topics in MDPI journals
Dr. Bruno Ramos-Molina
E-Mail Website
Guest Editor
Obesity and Metabolism Research Group, Biomedical Research Institute of Murcia (IMIB-Arrixaca), 30120 Murcia, Spain
Interests: metabolism; obesity; diabetes; non-alcoholic fatty liver disease; nutrition; microbiota; metabolomics; epigenetics
Special Issues, Collections and Topics in MDPI journals
Dr. Antonio J. Ruiz-Alcaraz
E-Mail Website
Guest Editor
1. Department of Biochemistry, Molecular Biology B and Immunology, School of Medicine, University of Murcia. Regional Campus of International Excellence “Campus Mare Nostrum”, 30100 Murcia, Spain
2. Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain
Interests: immunology; inflammation; macrophages; cell biology; in vitro models for drug development; cirrhosis; endometriosis; diabetes; insulin resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, microbiome research has evolved rapidly, and, nowadays, it  not only represents a hot topic in basic, preclinical, and clinical research, but also for food science and nutrition, as well as for the pharmaceutical research, with implications for all the related industry of these areas.

The discovery of the gut–brain axis as the crucial connection between gut microbiota and the nervous system, and the growing body of evidence on the connections between gut microbiota and nervous system physiology and pathology is increasing awareness around bidirectional communication along the microbiota–gut–brain axis (MGBA) mediated by biologically active molecules and metabolites.

The appearance of intestinal dysbiosis leads to changes in the bidirectional relationship of the MGBA. It can also impact the brain, as well as the aging and the deterioration of the nervous system, driving towards pathological conditions such as Alzheimer’s disease and stroke.

Comparatively, the MGBA can be influenced by nutrients and bioactive molecules, inducing the secretion of specific hormones, which can then lead to changes in the energy metabolism and expenditure. The design of drugs, functional foods, and ingredients based on bioactive molecules exploiting the involved mechanisms may offer interesting alternatives for the treatment of non-communicable and high-prevalence diseases, such as obesity, type 2 diabetes, and other metabolic syndromes and co-morbidities.

This Special Issue aims to gain novel and applicable knowledge on all these aspects, with contributions from the different areas involved.

Dr. Diego A. Moreno
Dr. Bruno Ramos-Molina
Dr. Antonio J. Ruiz-Alcaraz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gut–brain axis
  • gut microbiota
  • behavior
  • bioactive molecules
  • cognitive health
  • diabetes
  • in vitro models
  • in vivo models
  • hormones
  • intestine
  • obesity
  • probiotics
  • prebiotics
  • synbiotics

Published Papers

This special issue is now open for submission.
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