Recent Advances in Hepatitis E

Dear Colleagues,

Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. HEV is responsible for more than 50% of acute viral hepatitis cases in endemic countries. Approximately 2 billion individuals live in hepatitis E-endemic areas and, therefore, are at risk of infection. According to WHO, HEV causes about 20.1 million infections and 70,000 deaths every year. In developing countries with poor sanitation, this disease is transmitted through contaminated water and is associated with large outbreaks, affecting hundreds or thousands of people. In developed countries, autochthonous cases of HEV have been increasingly recognized in the past several years, associated with the consumption of contaminated food, such as pork, wildlife meat, or shellfish. Furthermore, other effective sources of transmission have been documented, suggesting a possibly much wider distribution of the virus. Despite the fact that this infectious disease usually takes a subclinical course, several extrahepatic manifestations have been reported in recent years, suggesting that the clinical magnitude of HEV may be underestimated. This significant increase in the knowledge of the epidemiology, pathogenesis, and clinical impact has pinpointed HEV as an emerging global health problem.

This Special Issue in International Journal of Environmental Research and Public Health is dedicated to the current knowledge of HEV and its future perspectives. We encourage the submission of original research papers and reviews on all aspects of HEV: life cycle, molecular epidemiology, diagnostic tools, transmission, pathogenesis, clinical impact, treatment, and prevention.

Prof. Dr. María Teresa Pérez-Gracia
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.