Cell Therapies in Hematology: Current Updates and Perspectives
A special issue of Hematology Reports (ISSN 2038-8330).
Deadline for manuscript submissions: closed (15 May 2024) | Viewed by 3414
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cell therapy and transfusion medicine have been the most common treatment option for hematological problems such as sickle cell anemia, thalassemia, hemophilia and bleeding disorders. Lately, with the technological advances, once seemingly challenging stem cell transplantation is now becoming more and more approachable with a widespread applicability including, but not restricted, to the primary immune deficiencies, hemoglobinopathies and heme neoplasms. For many primary immune deficiency diseases such as Wiskott Aldrich Syndrome, and SCID, hematopoietic stem cell transplantation remains the most curative treatment option. With significant graft versus leukemia response, allogeneic stem cell transplant is now becoming a routine practice for leukemia treatment. At the same time, improved gene engineering, viral vectors, and cell manipulation techniques, have enabled engineered stem cell transplants to be a lucrative treatment strategy for primary immune deficiencies and hemoglobinopathies. Cell therapies based on engineered T cells in the form of CAR-T, TCR-T and TIL, are showing their promise in several neoplasms. This special issue will be an update on cell therapies in hematology including recent developments, new ideas, and basic concepts, pre-clinical and clinical reports on advances and challenges in the field. We would like to invite basic and translational research manuscripts with an emphasis on cell therapies, specifically, novel vector designs, new gene therapy and bioassays for hematological problems, advanced cell preparation, transduction, and proliferation methods. Review articles covering the advances in cell therapies in benign or malignant hematological problem and chronological reports are welcome. Single case reports are also welcome if they present a sufficiently novel approach. We look forward to preparing a gripping special issue for clinicians, basic research scientists and interested audience.
Dr. Swati Garg
Guest Editor
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Keywords
- cell therapy
- hematopoietic stem cell transplant
- engineered T cells
- hemoglobinopathies,
- primary immune deficiencies
- leukemia
- bone marrow failure
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