Personalized Therapies and Clinical Outcomes for Older Patients with Lymphoma

Dear Colleagues,

By 2025, people 65 years or older will comprise about 20 percent of the total population in Japan. Among older adults, the percentage of patients over 80 years old will increase in Western Europe, China, and Japan. Recently several new drugs have been developed for the treatment of diffuse large B-cell lymphoma (DLBCL), including DLBCL biology, tumor microenvironment and epigenetics, some new therapies and drugs like molecular and signal pathway target therapy, chimeric antigen receptor T-cell therapy, immune checkpoint inhibitors, antibody drug-conjugate and tafasitamab. In clinical trials, patients with a poor performance status or renal, hepatic, or bone marrow dysfunction generally have been excluded, thus raising questions about the general applicability of data derived from such trials. This is particularly true for patients over 80 years. This special issue aims to collect and publish original research articles and reviews demonstrating recent advance in our knowledge on new diagnostic and therapeutic approaches in these clinical conditions with regarding the personalization of the patient's treatment based on his clinical characteristics, comorbidities, and preference.

Dr. Satoshi Yamasaki
Guest Editor

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