Personalized Therapies and Clinical Outcomes for Older Patients with Lymphoma

A special issue of Hematology Reports (ISSN 2038-8330).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1886

Special Issue Editor


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Guest Editor
Department of Hematology, St. Mary's Hospital, 422 Tsubukuhonmachi, Kurume 830-8543, Japan
Interests: older adults; diffuse large B-cell lymphoma; clinical trial; new drugs; comorbidity; dose intensity; comprehensive geriatric assessment; quality of life

Special Issue Information

Dear Colleagues,

By 2025, people 65 years or older will comprise about 20 percent of the total population in Japan. Among older adults, the percentage of patients over 80 years old will increase in Western Europe, China, and Japan. Recently several new drugs have been developed for the treatment of diffuse large B-cell lymphoma (DLBCL), including DLBCL biology, tumor microenvironment and epigenetics, some new therapies and drugs like molecular and signal pathway target therapy, chimeric antigen receptor T-cell therapy, immune checkpoint inhibitors, antibody drug-conjugate and tafasitamab. In clinical trials, patients with a poor performance status or renal, hepatic, or bone marrow dysfunction generally have been excluded, thus raising questions about the general applicability of data derived from such trials. This is particularly true for patients over 80 years. This special issue aims to collect and publish original research articles and reviews demonstrating recent advance in our knowledge on new diagnostic and therapeutic approaches in these clinical conditions with regarding the personalization of the patient's treatment based on his clinical characteristics, comorbidities, and preference.

Dr. Satoshi Yamasaki
Guest Editor

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Keywords

  • older adults
  • diffuse large B-cell lymphoma
  • clinical trial
  • new drugs
  • comorbidity
  • dose intensity
  • comprehensive geriatric assessment
  • quality of life

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Published Papers (1 paper)

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Research

10 pages, 840 KiB  
Article
Feasibility of Quality of Life Assessment in Patients with Lymphoma Aged ≥80 Years Receiving Reduced-Intensity Chemotherapy: A Single-Institute Study
by Satoshi Yamasaki
Hematol. Rep. 2024, 16(1), 1-10; https://doi.org/10.3390/hematolrep16010001 - 22 Dec 2023
Cited by 1 | Viewed by 1249
Abstract
Quality of life (QOL) must be carefully monitored in older patients with lymphoma who are suitable for chemotherapy, but few reports have assessed QOL in older patients who received reduced-intensity chemotherapy. This study investigated QOL in patients with lymphoma aged ≥80 years to [...] Read more.
Quality of life (QOL) must be carefully monitored in older patients with lymphoma who are suitable for chemotherapy, but few reports have assessed QOL in older patients who received reduced-intensity chemotherapy. This study investigated QOL in patients with lymphoma aged ≥80 years to clarify the feasibility of such assessments following reduced-intensity chemotherapy. QOL was prospectively analyzed (using the QOL Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL-ACD)] and the SF-36®, a comprehensive survey of patient health) among 13 patients (seven women) aged ≥80 years with lymphoma who received reduced-intensity chemotherapy at 4-week intervals at Kyushu University Beppu Hospital between June 2022 and August 2023. Patients were assessed at baseline, in the middle of the protocol, at the end of the protocol, and 6 months after the end of the protocol. The overall response rate was 69%. Almost all severe adverse events (10 patients) occurred during early cycles (cycles 1–2). Common adverse events included hematological toxicities such as neutropenia (10 patients). The daily activity (p = 0.048) and social attitude (p = 0.027) scores of the QOL-ACD and the general health perception (p = 0.044) and social functioning (p = 0.030) scores of the SF-36® were significantly improved during and after chemotherapy. Reduced-dose chemotherapy, if implemented before treatment selection, might permit evaluations of QOL in older patients aged ≥80 years; further investigation is warranted. Full article
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