Journal Description
Healthcare
Healthcare
is an international, scientific, peer-reviewed, open access journal on health care systems, industry, technology, policy, and regulation, and is published semimonthly online by MDPI. The European Medical Association (EMA), Ocular Wellness & Nutrition Society (OWNS) and Italian Society of Nephrology Nurses (SIAN) are affiliated with Healthcare and their members receive discounts on the article processing charges.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, SCIE and SSCI (Web of Science), PubMed, PMC, and other databases.
- Journal Rank: JCR - Q2 (Health Policy and Services) / CiteScore - Q1 (Leadership and Management)
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 21.5 days after submission; acceptance to publication is undertaken in 2.6 days (median values for papers published in this journal in the first half of 2025).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
- Companion journals for Healthcare include: Trauma Care and European Burn Journal.
- Journal Cluster of Healthcare Sciences and Services: Geriatrics, Journal of Ageing and Longevity, Healthcare, Hospitals, Hygiene, International Journal of Environmental Research and Public Health and Nursing Reports.
Impact Factor:
2.7 (2024);
5-Year Impact Factor:
2.8 (2024)
Latest Articles
The Reform That Was Never Completed: Why Greece Must Redesign Its Health Financing Architecture
Healthcare 2025, 13(24), 3213; https://doi.org/10.3390/healthcare13243213 (registering DOI) - 8 Dec 2025
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Health financing is a core determinant of the resilience and equity of health systems. Using WHO’s three-pillar framework as an orienting reference—rather than a prescriptive template—this article analyzes the evolution, structural shortcomings, and policy dilemmas of the Greek health financing model, within a
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Health financing is a core determinant of the resilience and equity of health systems. Using WHO’s three-pillar framework as an orienting reference—rather than a prescriptive template—this article analyzes the evolution, structural shortcomings, and policy dilemmas of the Greek health financing model, within a comparative European context. While many EU countries have strengthened public financing to ensure universal access, Greece maintains a hybrid, fragmented model in which out-of-pocket payments play a disproportionately large role. Despite recurrent reform attempts, Greece has not developed a cohesive public system with a clear commitment to social solidarity. Instead, the system has silently shifted into a de facto semi-privatized two-tier model that exacerbates social inequities, limits access and undermines efficiency. Drawing on international experience and documented policy lessons, the article proposes a strategic redesign of the health financing architecture. The proposal is conceptual and does not enter implementation specifics. Its central axis is the establishment of two national single purchasers of health services by level of care, with a clear allocation of responsibilities and authority, the Ministry of Health for hospital care, and the National Organization for Healthcare Services Provision (EOPYY) for primary, outpatient, and post-acute/rehabilitation care, to strengthen prevention, equitable access, and chronic care management while easing pressure on hospitals. The proposed model includes targeted investments in human resources and infrastructure, the enhancement of prospective payment mechanisms, the strengthening of primary care networks, and the leveraging of innovation. At the same time, it provides for reforms in governance, digital transformation of the system, and reallocation of resources based on principles of equity and efficiency. The proposed overall restructuring aims to strengthen financial protection, reduce inequities in access, and improve health outcomes through a publicly oriented, socially responsive, and strategically governed system.
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Open AccessArticle
Postural Assessment: An Online Survey of Practicing Chiropractors in the UK
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Jane Johnson, Josette Bettany-Saltikov, Paul van Schaik, Julien Cordry, David Newell and Roongtip Duangkaew
Healthcare 2025, 13(24), 3212; https://doi.org/10.3390/healthcare13243212 (registering DOI) - 8 Dec 2025
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Background: This study aimed to (a) determine how frequently chiropractors use postural assessment when treating patients with back or neck pain, (b) determine the rationale for the use of postural assessment by chiropractors, (c) examine the assessment methods employed, (d) explore which
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Background: This study aimed to (a) determine how frequently chiropractors use postural assessment when treating patients with back or neck pain, (b) determine the rationale for the use of postural assessment by chiropractors, (c) examine the assessment methods employed, (d) explore which specific aspects of posture are assessed and (e) determine the types of back and neck conditions being treated. Methods: An 11-item online questionnaire was developed. A link to this survey was distributed using SurveyMonkey to the entire membership of the Royal College of Chiropractors. Results: There were 272 respondents to the survey. Of the respondents, 79% ‘almost always’ used postural assessment when treating patients with back or neck pain. Respondents reported using postural assessment to help determine whether a patient was making progress (61.8%), provide an outcome measure (57.1%) and help inform the diagnosis (89.2%) and treatment plan (81.8%); almost all respondents (98.1%) reported carrying out a postural assessment visually, with no aids. Most respondents reported assessing their patients posteriorly, anteriorly and from both left and right sides, observing 44 specific anatomical items. The conditions treated included sacroiliac pain (96.7%), stiff neck (95.6%), non-specific lowback pain (92.6%), lumbar disc herniation (91.5%), cervical arthritis (89.7%), lumbar strain (87.1%), lumbar arthritis (86.4%), thoracic pain (86.4%), neck strain (84.9%) and whiplash (79.8%). Conclusions: The findings suggest that the unaided visual assessment of posture using a large range of anatomical points is used by UK chiropractors for the purposes of aiding diagnosis and treatment of patients with back and neck pathologies.
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Clinical Implications of Kinesiotaping for Forearm Muscle Function: Acute Effects on Grip Strength, Pain Sensitivity, and Muscle Oxygenation in Healthy Active Adults: A Randomized Controlled Trial
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José Ángel del-Blanco-Muñiz, Arturo Ladriñán-Maestro, Guillermo Vergara-Gatica, Cristóbal Orellana-García, Guillermo García-Pérez-de-Sevilla, Daniel Martín-Vera and Alberto Sánchez-Sierra
Healthcare 2025, 13(24), 3211; https://doi.org/10.3390/healthcare13243211 (registering DOI) - 8 Dec 2025
Abstract
Background/Objective: Kinesiotaping (KT) is widely used in sports and rehabilitation; however, evidence regarding its acute physiological effects on strength, pain sensitivity, and muscle oxygenation remains inconsistent. This study aimed to examine the acute effects of forearm KT on maximal grip strength, pressure pain
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Background/Objective: Kinesiotaping (KT) is widely used in sports and rehabilitation; however, evidence regarding its acute physiological effects on strength, pain sensitivity, and muscle oxygenation remains inconsistent. This study aimed to examine the acute effects of forearm KT on maximal grip strength, pressure pain threshold (PPT), and muscle oxygenation in healthy, physically active adults who performed a fatiguing exercise protocol. Methods: A randomized controlled trial was conducted with 28 participants (56 forearms), each randomly assigned to one of four conditions: KT applied proximal-to-distal, KT applied distal-to-proximal, placebo taping (no tension), or no taping (control). All assessments were performed within a single session, before and after a standardized forearm fatigue protocol. The outcomes included maximal and average grip strength (digital dynamometer), PPT (digital algometer), muscle oxygen saturation (SmO2) and total hemoglobin (THb) measured using near-infrared spectroscopy (NIRS). Data were analyzed using two-way ANOVA (time × group) with Bonferroni-adjusted post hoc tests. Results: All groups showed significant within-group reductions in grip strength after the fatigue protocol (Δ −2.8 to −7.9 kg; all p ≤ 0.01), confirming the effectiveness of fatigue induction. Between-group analysis revealed a significant effect only for SmO2 (p < 0.001; η2p = 0.317), with the proximal-to-distal KT group showing the largest post-fatigue increase (Δ +22.4; p < 0.001; Cohen’s d = 2.99) in SmO2. However, a comparable increase in SmO2 was also observed in the control group, suggesting a possible nonspecific reperfusion or oxygenation recovery effect. No between-group differences were observed in THb (p = 0.061), maximal grip strength (p = 0.092), average grip strength (p = 0.465), or PPT (p = 0.431). Conclusions: In healthy, physically active adults, forearm kinesiotaping did not produce significant acute effects on grip strength, pain threshold, or total hemoglobin levels following fatigue. Although a transient increase in SmO2 was observed with proximal-to-distal taping, this change likely reflects a non-specific post-fatigue reperfusion response rather than a direct enhancement of perfusion. These findings support a physiological, rather than clinical, interpretation of KT’s effects. Future studies should include clinical or athletic populations and explore whether repeated applications produce cumulative adaptations in muscle oxygenation and recovery processes.
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(This article belongs to the Special Issue Dysfunctions or Approaches of the Musculoskeletal System)
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Open AccessReview
Substance-Specific Treatment Responses and Resistance Patterns in Induced Psychoses: A Scoping Review of Antipsychotic Efficacy
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Valerio Ricci, Stefania Chiappini, Giovanni Martinotti and Giuseppe Maina
Healthcare 2025, 13(24), 3210; https://doi.org/10.3390/healthcare13243210 (registering DOI) - 8 Dec 2025
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Objective: To scope the available literature on antipsychotic treatment in substance-induced psychotic disorders, summarize evidence across substance categories, and highlight priorities for future research. Methods: This scoping review followed Arksey and O’Malley’s framework and PRISMA-ScR guidelines. A systematic search of PubMed, Scopus, Embase,
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Objective: To scope the available literature on antipsychotic treatment in substance-induced psychotic disorders, summarize evidence across substance categories, and highlight priorities for future research. Methods: This scoping review followed Arksey and O’Malley’s framework and PRISMA-ScR guidelines. A systematic search of PubMed, Scopus, Embase, PsycINFO, and Cochrane Library (January 1985–August 2025) identified studies examining antipsychotic treatment in cannabis-, stimulant-, and hallucinogen-induced psychoses. Two reviewers independently screened studies and extracted data using a standardized form. Given marked heterogeneity, findings were synthesized descriptively. Results: Seventeen studies met inclusion criteria: 3 randomized controlled trials (17.6%), 10 observational studies (58.8%), and 4 case series (23.5%). Most evidence involved cannabis-induced (n = 7) and methamphetamine-induced (n = 6) psychosis. Randomized trials showed comparable efficacy between risperidone and haloperidol for cannabis-induced psychosis, and between quetiapine and haloperidol for methamphetamine-induced psychosis. Case series suggested potential benefits of third-generation antipsychotics such as lurasidone and cariprazine. No controlled studies were identified for cocaine- or hallucinogen-induced psychoses. Conclusions: Evidence for antipsychotic treatment in substance-induced psychoses remains scarce and uneven. While conventional antipsychotics appear effective for cannabis- and methamphetamine-related presentations, other substances remain virtually unstudied. Substantial evidence gaps and limited methodological quality highlight urgent research needs.
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(This article belongs to the Special Issue Substance Abuse, Mental Health Disorders, and Intervention Strategies)
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Open AccessArticle
Perceptions of Fall Prevention and Engagement in Social Prescribing Activities Among Older Adults: A Cross-Sectional Study in Portugal
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Cristiano Matos, Cristina Rosa Baixinho, Violeta Alarcão, Maria Adriana Henriques, Ricardo Oliveira Ferreira, Tiago Nascimento, Miguel Arriaga, Tatiana Alves, Paulo Nogueira and Andreia Costa
Healthcare 2025, 13(24), 3209; https://doi.org/10.3390/healthcare13243209 (registering DOI) - 8 Dec 2025
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Background: Falls are a major cause of injury, functional decline, and reduced quality of life among older adults, posing a significant public health challenge. Social prescribing is gaining relevance in gerontology, offering structured strategies to engage individuals in preventive activities, including fall
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Background: Falls are a major cause of injury, functional decline, and reduced quality of life among older adults, posing a significant public health challenge. Social prescribing is gaining relevance in gerontology, offering structured strategies to engage individuals in preventive activities, including fall prevention strategies, through engagement in community-based activities. Aim: To examine older adults’ perception of the relevance of personal protection and development activities (e.g., prevention against falling) and compare sociodemographic, behavioural, and engagement profiles between those who agree and those who disagree with its relevance. Methods: A cross-sectional study was conducted with 613 older adults aged 65–93 years. Data collection included sociodemographic, health-related, and behavioural/social engagement variables (including perceptions regarding the benefits of social prescribing and interest in community-based activities). For this analysis, participants were dichotomized based on their agreement with the relevance of personal protection and development activities (e.g., prevention against falling). Of the 569 participants included, 538 (94.5%) agreed with its relevance and 31 (5.5%) disagreed. Descriptive and exploratory analyses were conducted to compare the two groups across variables. Multivariate logistic regression analyses were conducted to explore independent predictors of agreement across sociodemographic, behavioural, social prescribing, and health-related variables. Results: Significant differences were observed between the groups in awareness of active ageing (p = 0.018), volunteering (p < 0.001), participation in social and community activities (p < 0.001), and hobbies like gardening, fishing, or cooking (p = 0.002). Those who agreed with the importance of personal protection and development activities were significantly more likely to value a range of initiatives, including social activities in recreational organizations, physical activity in the community (e.g., hiking), artistic and creative activities (e.g., visual arts, music), technical or technological activities (e.g., do-it-yourself, computers), and cultural enrichment activities (e.g., visiting museums), (p < 0.001). Multivariate analyses showed no effects of sociodemographic or health-related factors, whereas behavioural and engagement-related variables—including volunteering, hobbies, and several social prescribing activities—significantly predicted agreement with the relevance of personal protection and development activities. Discussion: The findings suggest that older adults who perceive fall prevention as relevant are more actively engaged in diverse health-promoting activities, including volunteering, hobbies, and community-based programmes. This pattern may reflect higher health literacy, stronger social networks, and proactive attitudes towards ageing. Conclusions: Perceptions of fall prevention are closely linked to broader patterns of engagement in health-promoting activities among older adults. Recognizing and addressing differences in how these activities are valued can inform more inclusive and targeted gerontological interventions.
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(This article belongs to the Special Issue Fall Prevention and Geriatric Nursing)
Open AccessReview
Unveiling the Algorithm: The Role of Explainable Artificial Intelligence in Modern Surgery
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Sara Lopes, Miguel Mascarenhas, João Fonseca, Maria Gabriela O. Fernandes and Adelino F. Leite-Moreira
Healthcare 2025, 13(24), 3208; https://doi.org/10.3390/healthcare13243208 - 8 Dec 2025
Abstract
Artificial Intelligence (AI) is rapidly transforming surgical care by enabling more accurate diagnosis and risk prediction, personalized decision-making, real-time intraoperative support, and postoperative management. Ongoing trends such as multi-task learning, real-time integration, and clinician-centered design suggest AI is maturing into a safe, pragmatic
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Artificial Intelligence (AI) is rapidly transforming surgical care by enabling more accurate diagnosis and risk prediction, personalized decision-making, real-time intraoperative support, and postoperative management. Ongoing trends such as multi-task learning, real-time integration, and clinician-centered design suggest AI is maturing into a safe, pragmatic asset in surgical care. Yet, significant challenges, such as the complexity and opacity of many AI models (particularly deep learning), transparency, bias, data sharing, and equitable deployment, must be surpassed to achieve clinical trust, ethical use, and regulatory approval of AI algorithms in healthcare. Explainable Artificial Intelligence (XAI) is an emerging field that plays an important role in bridging the gap between algorithmic power and clinical use as surgery becomes increasingly data-driven. The authors reviewed current applications of XAI in the context of surgery—preoperative risk assessment, surgical planning, intraoperative guidance, and postoperative monitoring—and highlighted the absence of these mechanisms in Generative AI (e.g., ChatGPT). XAI will allow surgeons to interpret, validate, and trust AI tools. XAI applied in surgery is not a luxury: it must be a prerequisite for responsible innovation. Model bias, overfitting, and user interface design are key challenges that need to be overcome and will be explored in this review to achieve the integration of XAI into the surgical field. Unveiling the algorithm is the first step toward a safe, accountable, transparent, and human-centered surgical AI.
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(This article belongs to the Section Artificial Intelligence in Healthcare)
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Open AccessArticle
Exploring the Implications of Aged Care Reform on Allied Health Workforce and Capacity to Deliver Palliative and End-of-Life Care
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Olivia Farrer and Jennifer Tieman
Healthcare 2025, 13(24), 3207; https://doi.org/10.3390/healthcare13243207 - 8 Dec 2025
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Background: The aged care sector in Australia is increasingly focused on a personalised care approach which prioritises dignity and respect for older adults. With a growing ageing population, we are also seeing more complexity in health needs and palliative care. Allied health
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Background: The aged care sector in Australia is increasingly focused on a personalised care approach which prioritises dignity and respect for older adults. With a growing ageing population, we are also seeing more complexity in health needs and palliative care. Allied health professionals are skilled in the delivery of care that fosters independence and quality of life as health deteriorates. However, in the recent aged care reform, there has been concern that allied health are not clearly recognised for their role in aged and palliative care. Methods: Qualitative study using semi-structured interviews with aged care service providers and allied health peak body representatives and clinicians to understand the perceived impact of aged care reforms in Australia on allied health workforce. Guided by a constructivist epistemology, reflexive thematic analysis was used to understand key themes. Results: Eight interviews were conducted, yielding one key theme and three sub themes. These were person-centred palliative care, advocates, location of care matters, and funding model, with the key theme of the funding model intersecting with all other themes. Conclusions: The issue of recognising allied health best practice in aged and palliative care is multifactorial. At the heart of the problem appears to be how well recognised allied health disciplines are for the value of their contribution, and constraints imposed by funding models and sector priorities on the sufficient input of the full scope of practice. Without a sufficient and skilled workforce supported to enact their full scope, the ability to deliver a personalised care approach and outcomes for our ageing population will suffer.
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Open AccessSystematic Review
Nonpharmacological Intervention Effects on Middle-Aged Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis
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Ji-Hyun Kim and Hea-Jin Yu
Healthcare 2025, 13(24), 3206; https://doi.org/10.3390/healthcare13243206 (registering DOI) - 8 Dec 2025
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Background: Middle-aged women frequently experience diverse physical and psychological symptoms, including depression, anxiety, sleep disturbances, vasomotor symptoms, and reduced quality of life, during menopause. With increasing concerns regarding the side effects of hormone therapy, nonpharmacological interventions have emerged as safer alternatives for symptom
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Background: Middle-aged women frequently experience diverse physical and psychological symptoms, including depression, anxiety, sleep disturbances, vasomotor symptoms, and reduced quality of life, during menopause. With increasing concerns regarding the side effects of hormone therapy, nonpharmacological interventions have emerged as safer alternatives for symptom management. Purpose: This systematic review and meta-analysis evaluated the effectiveness of nonpharmacological interventions for menopausal symptoms in middle-aged women. Methods: Thirty-two randomized controlled trials were selected from eight international and domestic databases. Interventions were categorized as nutritional or herbal, psychological, exercise-based, and complementary therapies. Risk of bias was assessed using the Cochrane risk of bias tool, and meta-analyses were performed using a random effects model. Results: Nonpharmacological interventions significantly reduced symptoms of depression (standardized mean difference (SMD) = −1.10), anxiety (−0.82), sleep disturbances (−0.90), menopausal symptoms (−1.18), and hot flashes (−0.34). Improvement in quality of life was observed, but it was not statistically significant (SMD = 1.40). Subgroup analyses revealed that nutritional and herbal interventions had the most consistent effects, and psychological and exercise-based interventions were particularly effective for improving sleep outcomes and emotional well-being. Conclusions: Nonpharmacological interventions effectively improve menopausal symptoms and quality of life, with tailored and multifaceted approaches showing the greatest impact. Nurse-led, community-based programs are key delivery platforms, and sustainable outcomes require standardized protocols, cultural responsiveness, and ongoing evaluation.
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(This article belongs to the Special Issue Menopause Transition and Postmenopausal Health)
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Open AccessArticle
Leading with Integrity: Impact of Ethical Leadership on Performance of Healthcare Professionals in Saudi Arabia
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Badr K. Aldhmadi, Rakesh Kumar, Bilesha Perera and Mohammad A. Algarni
Healthcare 2025, 13(24), 3205; https://doi.org/10.3390/healthcare13243205 - 8 Dec 2025
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Background/Objectives: Ethical leadership (EL) propels and enhances employee performance (EP), especially in healthcare, where ethics are paramount. However, existing research lacks a focus on how EL functions within Saudi Arabia (SA)’s public healthcare context. Primarily, this research investigates how EL directly affects EP.
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Background/Objectives: Ethical leadership (EL) propels and enhances employee performance (EP), especially in healthcare, where ethics are paramount. However, existing research lacks a focus on how EL functions within Saudi Arabia (SA)’s public healthcare context. Primarily, this research investigates how EL directly affects EP. The research also investigates how organizational support (OS) influences EP and moderates the EL-to-EP relationship. Methods: This cross-sectional study consisted of 312 responses from doctors, nurses, and other administrators within Saudi public healthcare units. To analyze the collected data statistically, structural equation modeling (SEM) was opted for with the help of Smart-PLS 4. It helped to assess the direct effects of EL and OS on EP and further examine OS’s moderating role. A multigroup analysis (MGA) was also conducted in comparative form. It examined subgroup variations across gender, age, marital status, experience, and departmental affiliation. Results: The findings confirmed a positive impact of EL on EP. Moreover, a positive effect of OS on EP was also confirmed. Similarly, OS strengthened the positive effect of EL on EP. The MGA revealed variations across employee groups. It offered practical insights into how EL and OS function in diverse organizational contexts. These differences across groups reflect cultural and structural features of Saudi public healthcare. Conclusions: The extended research contributes to the literature on ethical leadership (EL) theory by applying contextual and demographic contingencies within the Saudi public healthcare sector. It also introduces OS as a significant moderator and provides actionable implications for improving performance through context-sensitive leadership and support strategies.
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(This article belongs to the Section Healthcare Organizations, Systems, and Providers)
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Open AccessArticle
Implementation of the Maynard-Based Risk Assessment Model for Venous Thromboembolism Inpatient Prophylaxis: A Before-and-After Study
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Belisa Marin Alves, Raquel Pereira Vieira, Larissa Luma Tomasi Febras, Mauricio Santiago Soper, Jonas Michel Wolf, Vania Rohsig, Sidiclei Machado Carvalho, Cássia Cristine Damasio de Lima, Cintia Lazzari, Daniel Luft Machado, Luiz Antônio Nasi and Marcelo Basso Gazzana
Healthcare 2025, 13(24), 3204; https://doi.org/10.3390/healthcare13243204 - 8 Dec 2025
Abstract
Background/Objectives: Venous thromboembolism (VTE) is a common and potentially fatal condition in hospitalized patients. Although appropriate risk assessment and prophylaxis reduce VTE events, preventive measures remain underutilized. This study aimed to evaluate the effectiveness of an electronic risk stratification tool within multifaceted interventions
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Background/Objectives: Venous thromboembolism (VTE) is a common and potentially fatal condition in hospitalized patients. Although appropriate risk assessment and prophylaxis reduce VTE events, preventive measures remain underutilized. This study aimed to evaluate the effectiveness of an electronic risk stratification tool within multifaceted interventions for implementing VTE prophylaxis protocols in adult clinical and surgical patients at Hospital Moinhos de Vento, Brazil. Methods: A prospective before-and-after hospital-based study was conducted from 2017 to 2019, including 772 patients admitted to clinical and surgical units for over 48 h. The electronic tool based on the Maynard risk assessment model classified patients’ VTE risk. Padua and Caprini scores served as reference standards for clinical and surgical patients, respectively. Prophylaxis was considered adequate if it complied with institutional protocols. Results: Globally, the Maynard model classified 0.9% as low risk, 76.4% intermediate, and 22.7% high risk, differing notably in orthopedic surgical patients. Overall prophylaxis adequacy was 69.3%, with no significant difference between phases. Orthopedic surgical patients showed a significant decrease in prophylaxis adequacy in phase 2 (p = 0.02). Conclusions: The Maynard model underestimated high-risk classification compared to Padua and Caprini scores, especially in orthopedic surgical patients. Implementation of the electronic tool alongside multifaceted interventions did not improve prophylaxis adequacy.
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(This article belongs to the Special Issue Data Analytics in the Context of Value-Based Healthcare)
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Open AccessProject Report
Ten Years of ECHO Chronic Pain and Opioid Stewardship in Ontario: Impact and Future Directions
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Andrea D. Furlan, Q. Jane Zhao, Paul Taenzer, Andrew J. Smith, Ralph Fabico, Kiera Morgan, Rhonda Mostyn and John F. Flannery
Healthcare 2025, 13(24), 3203; https://doi.org/10.3390/healthcare13243203 - 8 Dec 2025
Abstract
Background: ECHO Pain is a health professions education model that uses telehealth technology to connect specialists in academic centres to healthcare professionals who work in the community to disseminate best practice knowledge and foster interprofessional collaboration to support real patient cases. Methods
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Background: ECHO Pain is a health professions education model that uses telehealth technology to connect specialists in academic centres to healthcare professionals who work in the community to disseminate best practice knowledge and foster interprofessional collaboration to support real patient cases. Methods: This paper summarizes 10 years of ECHO Pain implementation and evaluation in Ontario. We reviewed participants’ demographics, characteristics of cases presented in ECHO sessions, and the research output of this ECHO Pain program. Results: From June 2014 to June 2024, there were 529 sessions, 1527 healthcare professionals from urban and rural regions attended ECHO, and 25,898 h of continuing medical education credits were provided. We published 11 papers in peer-reviewed scientific journals using qualitative and quantitative research methods. Conclusions: ECHO Pain has been implemented and sustained in Ontario for 10 years, with demonstrated interprofessional education and an ongoing community of practice to discuss chronic pain cases. ECHO Pain is filling a significant gap in health professions education related to chronic pain in Ontario, especially for primary care professionals living in rural, remote, and underserved areas.
Full article
(This article belongs to the Special Issue Improving Primary Care Through Healthcare Education)
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Open AccessArticle
The Impact of a Spanish Online and Telephone Intervention for Caregivers of Veterans Post-Stroke: Findings on Caregiver Burden
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Janet Lopez, Sara Snyder, Tatiana Orozco, Heather Foulke, Melanie Orejuela, Alexa Farriss, Naiomi Rivera-Rivera, Nathaniel Eliazar-Macke, Keryl Motta-Valencia and I. Magaly Freytes
Healthcare 2025, 13(24), 3202; https://doi.org/10.3390/healthcare13243202 - 8 Dec 2025
Abstract
Background/Objectives: Hispanic caregivers report higher levels of burden and poorer mental health compared to non-Hispanic caregivers. While problem-solving interventions have shown promise in improving stroke caregiver and patient well-being, they have not been specifically tailored or tested with Hispanic stroke caregivers. This study
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Background/Objectives: Hispanic caregivers report higher levels of burden and poorer mental health compared to non-Hispanic caregivers. While problem-solving interventions have shown promise in improving stroke caregiver and patient well-being, they have not been specifically tailored or tested with Hispanic stroke caregivers. This study aimed to evaluate the effectiveness of a telephone- and online-based problem-solving intervention that was culturally adapted for Spanish-speaking Hispanics on caregiver burden. Methods: A two-arm parallel randomized clinical trial (NCT03142841) with repeated measures was conducted with 210 Hispanic caregivers of veterans who had experienced a stroke within the past year. Participants were recruited from three VA medical centers. The intervention consisted of 8-telephone sessions using online materials conducted by a trained interventionist. Participants in the standard group received usual VA resources they would have received as part of routine care such as stroke-related information. Chi-square tests and regression analyses were used to assess outcomes at 9 and 21 weeks. Results: Most participants were female (88%), college-educated (49%), and spouses or partners of a veteran (46%). Caregivers in the intervention group showed significantly greater reductions in caregiver burden (p = 0.011; p < 0.001) compared to the standard care group. Conclusions: Similarly to others reporting positive findings with non-Hispanic caregivers, these findings suggest that the problem-solving intervention can potentially alleviate Hispanic Spanish-speaking stroke caregivers’ burden by improving coping skills, problem-solving, and social support. Further research is needed to address gaps in effective interventions and promote equitable care for this population.
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(This article belongs to the Special Issue Recent Advances and Innovation in Telehealth Use Among Older Adults)
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Open AccessArticle
Linking Motor and Cognitive Decline in Aging: Gait Variability and Working Memory as Early Markers of Frailty
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Elisa Valeriano-Paños, Mª Nieves Moro-Tejedor, Mª Jesús Santamaria-Martin, Susana Vega-Albala, María Valeriano-Paños, Juan Francisco Velarde-García and Luis Enrique Roche-Seruendo
Healthcare 2025, 13(24), 3201; https://doi.org/10.3390/healthcare13243201 - 7 Dec 2025
Abstract
Background/Objectives: Frailty is an age-related clinical syndrome characterized by diminished physiological reserves and increased vulnerability to adverse outcomes. Growing evidence suggests that frailty involves shared brain networks that regulate both gait and cognitive functions. This study aimed to examine the relationship between frailty
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Background/Objectives: Frailty is an age-related clinical syndrome characterized by diminished physiological reserves and increased vulnerability to adverse outcomes. Growing evidence suggests that frailty involves shared brain networks that regulate both gait and cognitive functions. This study aimed to examine the relationship between frailty status, spatiotemporal gait parameters, and cognitive functions in community-dwelling older adults. Methods: A cross-sectional study was conducted with 99 adults aged ≥70 years, classified as non-frail, prefrail, or frail according to the Fried phenotype. Gait parameters were measured under usual and fast walking conditions using the OptoGait® photoelectric system. Cognitive status was assessed with the Montreal Cognitive Assessment (MoCA) and a comprehensive neuropsychological battery. Multivariate logistic regression analyses were performed to identify factors associated with transitions between frailty stages. Results: The prevalence of frailty was 9.1%, with 51.5% prefrail and 39.4% non-frail. The transition from non-frail to prefrail was associated with shorter stride length at fast pace (OR = 0.92, 95% CI: 0.88–0.96), mild cognitive impairment (OR = 3.71, 95% CI: 1.08–12.69), depressive symptoms (OR = 1.82, 95% CI: 1.26–2.62), and female sex (OR = 4.94, 95% CI: 1.20–16.77). The transition from prefrail to frail was linked to increased stride time variability at fast pace (OR = 2.94, 95% CI: 1.34–6.44) and poorer working memory (OR = 0.40, 95% CI: 0.16–0.97). Conclusions: Shorter stride length, mild cognitive impairment, and depressive symptoms emerged as key markers of the transition from non-frailty to prefrailty, whereas increased stride time variability and poorer working memory distinguished prefrail from frail individuals. These findings highlight gait- and executive-function-related markers as sensitive early indicators of vulnerability. Incorporating quantitative gait assessment and brief cognitive screening into routine geriatric evaluations may substantially enhance early detection and support targeted preventive strategies for healthy aging.
Full article
(This article belongs to the Special Issue Multidimensional Aging Care: Gait, Cognition, Sensory Decline, and Psychosocial Vulnerability in Later Life)
Open AccessArticle
Multidimensional Stratification of Severe Disability: Demographic, Clinical, Geographic, Socio-Economic Profiles and Healthcare Pathways in a Cross-Sectional Italian Cohort
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Rita Chiaramonte, Tamara Civello, Giuseppe Laganga Senzio, Liberato Longo, Alessandro Santo De Caro, Fabrizio Li Gotti and Michele Vecchio
Healthcare 2025, 13(24), 3200; https://doi.org/10.3390/healthcare13243200 - 7 Dec 2025
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Background: Individuals with severe disability require intensive and long-term healthcare, rehabilitation and social support. Updated population data are essential to inform planning and resource allocation. This study aimed to quantify—with a cross-sectional analysis conducted in 2025—the demographic, clinical, socioeconomic, and geographic characteristics
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Background: Individuals with severe disability require intensive and long-term healthcare, rehabilitation and social support. Updated population data are essential to inform planning and resource allocation. This study aimed to quantify—with a cross-sectional analysis conducted in 2025—the demographic, clinical, socioeconomic, and geographic characteristics of individuals with severe disability within the Provincial Health Authority (ASP) of Catania (Sicily) in Italy, and to identify statistically significant differences across subgroups. Methods: A cross-sectional analysis was conducted on 3277 individuals officially certified as having severe disability under the Italian Ministerial Decree of 26 September 2016. Data were extracted from administrative records and stratified by age, sex, clinical classification, income level, and healthcare district. Associations were tested using chi-square statistics. Results: Participants had a mean age of 39.14 ± 28.64 years; Minors represented 33% of the disability cohort (vs. 19.4% minors in the general provincial population) with a mean age 10.28 ± 3.55. Adults accounted for 67% of the cohort (vs. 81% adults in the general population), with a mean age of 69.94 ± 24.61 years. Females constituted 43% of the sample (compared with 51% females in the provincial population), whereas males represented 57% (vs. 49% males in the general population). Most individuals (95.9% of the cohort) had an income level below €25,000/year. Conclusions: The study reveals substantial demographic, socioeconomic, and clinical heterogeneity among individuals with severe disability and highlights significant district-level disparities. Notably, minors appear markedly over-represented in the disability cohort compared with the general population, while females are under-represented, indicating potential age- and sex-related differences in disability burden, access to assessment, or underlying diagnostic patterns. These findings indicate the need for stratified, district-sensitive planning approaches, ensuring equitable access to services and optimizing allocation of healthcare and social resources.
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Open AccessArticle
Intelligent Patient Management in Viral Diseases: An Integrated Regression Model and Multi-Criteria Decision-Making Approach to Convalescent Plasma Transfusion
by
Thura J. Mohammed, Ahmed S. Albahri, Alhamzah Alnoor, Khai Wah Khaw, Xin Ying Chew and Shiuh Tong Lim
Healthcare 2025, 13(24), 3199; https://doi.org/10.3390/healthcare13243199 - 6 Dec 2025
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Background/Objectives: Viral diseases remain a major threat to global public health, particularly during outbreaks when limited therapeutic resources must be rapidly and fairly distributed to large populations. Although Convalescent Plasma (CP) transfusion has shown clinical promise, existing allocation frameworks treat patient prioritization, donor
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Background/Objectives: Viral diseases remain a major threat to global public health, particularly during outbreaks when limited therapeutic resources must be rapidly and fairly distributed to large populations. Although Convalescent Plasma (CP) transfusion has shown clinical promise, existing allocation frameworks treat patient prioritization, donor selection, and validation as separate processes. This study proposes a credible, converged smart framework integrating multicriteria decision-making (MCDM) and regression-based validation within a telemedicine environment to enable transparent, data-driven CP allocation. Methods: The proposed framework consists of three stages: (i) Analytic Hierarchy Process (AHP) for weighting five clinically relevant biomarkers, (ii) dual prioritization of patients and donors using Order Preference by Similarity to Ideal Solution (TOPSIS) and Višekriterijumsko Kompromisno Rangiranje (VIKOR) with Group Decision-Making (GDM), and (iii) regression-based model selection to identify the most robust prioritization model. An external dataset of 80 patients and 80 donors was used for independent validation. Results: The external GDM AHP-VIKOR prediction model demonstrated strong predictive performance and internal consistency, with R2 = 0.971, MSE = 0.0010, RMSE = 0.032, and MAE = 0.025. Correlation analysis confirmed biomarker behavior consistency and stability in ranking, thereby reinforcing the reliability of the prioritization outcomes. Conclusions: The proposed patient–donor matching framework is accurate, interpretable, and timely. This work presents an initial step toward realizing safe AI-enabled transfusion systems within telemedicine, supporting transparent and equitable CP allocation in future outbreak settings.
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Open AccessSystematic Review
A Systematic Review and Meta-Analysis of Physical Activity Interventions in Colorectal Cancer Survivors: An Evidence Evaluation Attempt Across Racial/Ethnic Groups
by
Yves Paul Vincent Mbous, Rowida Mohamed, George A. Kelley and Kimberly Michelle Kelly
Healthcare 2025, 13(24), 3198; https://doi.org/10.3390/healthcare13243198 - 5 Dec 2025
Abstract
Aims: Recommendations for cancer survivors concur regarding physical activity (PA), and elucidating factors governing PA uptake among colorectal cancer (CRC) survivors is needed. This study examined the impact of PA interventions and investigated the variation in PA across several characteristics, including race/ethnicity. Design:
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Aims: Recommendations for cancer survivors concur regarding physical activity (PA), and elucidating factors governing PA uptake among colorectal cancer (CRC) survivors is needed. This study examined the impact of PA interventions and investigated the variation in PA across several characteristics, including race/ethnicity. Design: We performed a systematic review and aggregate data meta-analysis of randomized controlled trials (RCTs) of PA interventions. Data Sources: We used studies from CENTRAL, PubMed (NCBI), PsycINFO (EBSCOhost), CINAHL (EBSCOhost) with full text, Scopus (ELSEVIER), and the Web of Science (CLARIVATE) (1 May 1993–1 September 2023). Methods: For the meta-analysis, the inverse variance heterogeneity (IVhet) model was used to pool standardized mean difference effect sizes (Hedge’s g) for our primary outcome, changes in PA. Results: Sixteen studies representing 1668 participants were included in the meta-analysis. A moderate, statistically significant increase in PA was observed (g = 0.44, 95% CI 0.12–0.76; p = 0.01). However, a large amount of inconsistency was observed (I2 = 80.8%, 95% CI, 36.1% to 90.9%), as well as major asymmetry suggestive of small-study effects (publication bias, LFK = 3.04). Only 28% of trials reported race/ethnicity, limiting equity analyses. Subgroups comparing atheoretical vs. theory-based interventions did not differ statistically. Meta-regression results suggested associations with specific behavior change theories and delivery features. Based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment, the overall certainty of evidence was considered low. Conclusions: There is low-certainty evidence that PA interventions may improve PA among CRC survivors. Future trials should (i) recruit and report diverse samples in a clear and transparent manner, (ii) explicitly map theory constructs to techniques and test mechanisms, and (iii) report fidelity and clinically meaningful thresholds alongside behavioral outcomes.
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(This article belongs to the Special Issue Physical Activity, Healthy Lifestyle and Well-Being Across the Lifespan: Second Edition)
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Open AccessArticle
Effects of Continuous Glucose Monitoring on Glycemic Control, Mental Health and Self-Management in Adults with Type 1 Diabetes: A Randomized Controlled Trial
by
Rocío Romero-Castillo, Manuel Pabón-Carrasco, Shakira Kaknani-Uttumchandani and José Antonio Ponce-Blandón
Healthcare 2025, 13(24), 3197; https://doi.org/10.3390/healthcare13243197 - 5 Dec 2025
Abstract
Background/Objectives: Adults with type 1 diabetes (T1D) often experience psychological distress that interferes with their ability to maintain optimal self-care. The purpose of this study was to evaluate the effectiveness of the Diabself-care, a nurse-led structured diabetes self-management education (DSME) intervention
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Background/Objectives: Adults with type 1 diabetes (T1D) often experience psychological distress that interferes with their ability to maintain optimal self-care. The purpose of this study was to evaluate the effectiveness of the Diabself-care, a nurse-led structured diabetes self-management education (DSME) intervention designed to improve glycemic control, self-care practices and mental health among adults with T1D. Methods: A total of 224 adults with type 1 diabetes were randomized and final analyses included 110 participants in the intervention group and 106 in the control group. The intervention group received the Diabself-care program, consisting of five daily 90 min sessions integrating education, skill training, self-management and coping strategies in addition to usual care. The control group received standard diabetes care. Outcomes were assessed at baseline, 1 month and 3 months. The primary measure was glycemic control and secondary outcomes including self-management, anxiety and depressive symptoms. Results: The intervention group achieved a significant increase in time in range at both 1 and 3 months. Self-management adherence improved significantly in the intervention group (p < 0.001). Anxiety and depression scores decreased significantly in the intervention group at 1 and 3 months, while they remained unchanged in controls. Regression analyses identified depressive symptoms as the strongest predictor of anxiety (OR = 4.34, 95% CI = 2.99–6.28, p < 0.001), while female sex, older age, and low self-management were predictors of depression. Belonging to the intervention group was strongly protective against depression (OR = 0.11, 95% CI = 0.05–0.24, p < 0.001). Conclusions: The Diabself-care program significantly improved glycemic control, self-management, and psychological outcomes in adults with T1D. These findings highlight the dual clinical and mental health benefits of structured nurse-led DSME, supporting its integration into routine diabetes care. The trial is registered at ClinicalTrials.gov, ID: NCT05159843.
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(This article belongs to the Section Chronic Care)
Open AccessArticle
The Effectiveness of Currently Recommended Questionnaires in Identifying Scoliosis Among Chronic Back Pain Patients: A Cross-Sectional Study
by
Fabio Zaina, Tito Bassani, René Castelein, Carmelo Pulici and Stefano Negrini
Healthcare 2025, 13(24), 3196; https://doi.org/10.3390/healthcare13243196 - 5 Dec 2025
Abstract
Background/Objectives: Low back pain (LBP) is the most prevalent musculoskeletal condition, significantly impacting quality of life and incurring high social costs. Although non-specific (without anatomical abnormalities) LBP accounts for nearly 80% of cases, LBP due to adult spinal deformities (ASDs), including scoliosis, remains
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Background/Objectives: Low back pain (LBP) is the most prevalent musculoskeletal condition, significantly impacting quality of life and incurring high social costs. Although non-specific (without anatomical abnormalities) LBP accounts for nearly 80% of cases, LBP due to adult spinal deformities (ASDs), including scoliosis, remains a major concern. Several patient-reported outcome measures (PROMs)—notably the Oswestry Disability Index (ODI), Scoliosis Research Society-22 questionnaire (SRS-22), and Core Outcome Measure Instrument (COMI)—are recommended for assessment in these populations. This study aims to verify if these PROMs can effectively distinguish between adults with scoliosis-associated LBP (SLBP) and those with non-specific LBP (LBP). Methods: subjects were categorised as either having idiopathic/degenerative scoliosis (>10° Cobb angle in the coronal plane) with LBP, or non-specific LBP. Statistical comparisons applied non-parametric tests (Wilcoxon rank-sum, Mood’s median, chi-square), Spearman’s correlation, and generalised linear regression analyses. Results: Among 1092 subjects (552 SLBP; 540 LBP), median ODI scores were similar between groups, while SRS-22 scores were modestly higher in the SLBP cohort. Females consistently reported higher ODI and lower SRS-22 scores. Significant correlations arose between ODI and COMI, with moderate inverse associations with SRS-22. Regression analysis demonstrated that pathology group, gender, age, and BMI weakly predicted PROM scores. Conclusions: ODI and SRS-22 perform comparably in assessing disability in adults with LBP regardless of scoliosis, suggesting they cannot discriminate different pathologies. These findings underscore the importance of employing multiple PROMs to capture clinical dimensions.
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(This article belongs to the Special Issue Scoliosis Deformity—Etiological Aspects, Management and Rehabilitation)
Open AccessCase Report
Effects of Adapted Physical Activity Programs on Body Composition and Sports Performance in a Patient with Parkinson’s Disease: A Case Report
by
Luciana Zaccagni, Natascia Rinaldo, Gaetano Campanale, Antonio Pastore, Francesca Rametta and Emanuela Gualdi-Russo
Healthcare 2025, 13(24), 3195; https://doi.org/10.3390/healthcare13243195 - 5 Dec 2025
Abstract
The benefits of physical activity on physical and mental health are well established. Exercise can be particularly advantageous in neurodegenerative disorders such as Parkinson’s disease (PD), where progressive loss of muscle mass and impaired motor performance are common. We report the case of
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The benefits of physical activity on physical and mental health are well established. Exercise can be particularly advantageous in neurodegenerative disorders such as Parkinson’s disease (PD), where progressive loss of muscle mass and impaired motor performance are common. We report the case of a 58-year-old man with PD who underwent a structured, adapted physical activity program in preparation for a relay swim across the Strait of Messina (Sicily, Italy). The aim was to evaluate changes in body composition (fat mass, fat-free mass) and performance following four months of adapted swimming training, alongside adapted physical activity in the gym and Nordic walking. The patient swam 1300 m in 42 min and 38 s in the relay, which was a marked improvement from the baseline and subsequent assessments. In conclusion, while a longer follow-up period and a larger patient sample would be necessary, the findings from this case study suggest that the adapted exercise program improved both physical fitness and body composition. This generally supports the key role of physical activity in managing Parkinson’s disease and, in particular, the positive effects of adaptive sports training.
Full article
(This article belongs to the Special Issue Physical Activity, Exercise, and Sport in People with Disabilities: Strategies for Health Promotion)
Open AccessArticle
Improved Gingival Margin Stability with a Digital Workflow in Esthetic Crown Lengthening: A Single-Center, Interventional, Non-Randomized, Open-Label Comparative Clinical Study on 622 Teeth
by
Sorin Gheorghe Mihali, Dan Loloș, Andreea Raissa Hojda, Bogdan Antonio Loloș and Roxana Oancea
Healthcare 2025, 13(24), 3194; https://doi.org/10.3390/healthcare13243194 - 5 Dec 2025
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Background/Objectives: The stability of the gingival margin after crown lengthening is a key determinant of esthetic success in anterior rehabilitation. Digital workflows have been proposed to improve surgical precision, but their long-term impact on marginal stability remains insufficiently substantiated. Methods: A
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Background/Objectives: The stability of the gingival margin after crown lengthening is a key determinant of esthetic success in anterior rehabilitation. Digital workflows have been proposed to improve surgical precision, but their long-term impact on marginal stability remains insufficiently substantiated. Methods: A total of 87 patients (622 maxillary anterior and premolar teeth) who underwent esthetic crown lengthening were retrospectively evaluated. Patients were allocated to either a digitally guided workflow (G1, n = 62) or a freehand approach (G2, n = 25). Gingival margin stability was assessed using standardized intraoral photography and calibrated digital measurements at baseline, 1–2 months, and 12 months. Recurrence, periodontal parameters, complications, and patient satisfaction (VAS) were recorded. Mixed-effects models accounted for the clustering of teeth within patients. Results: Both workflows achieved predictable crown lengthening outcomes. At 12 months, median gingival margin recurrence was significantly lower in the guided group (G1: 0.14 mm [IQR 0.10–0.19]) compared with the freehand group (G2: 0.27 mm [IQR 0.20–0.34]) (p < 0.001). Secondary surgical revision was required in 1.6% of G1 patients versus 16.0% of G2 patients (p < 0.001). Patient satisfaction was high overall but greater in G1 (mean VAS 9.65 ± 0.52) than in G2 (8.96 ± 0.73). No major biological complications occurred. Conclusions: Digitally guided crown lengthening resulted in improved gingival margin stability and reduced the need for secondary correction compared with the freehand approach. Precise control of the bone crest position relative to the planned gingival margin is critical for long-term esthetic success.
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