Genomic Profiling for Biomarker Discovery and Validation

Dear Colleagues,

Due to the constantly decreasing cost of high-throughput genomic technologies, we are beginning to appreciate the breadth of information we can learn from genomic profiling. For example, genomic profiling can reveal the timing of aberrations that occur as a disease develops and the spatial heterogeneity within a tissue, person, or population. Genomic biomarkers have become valuable tools for (1) disease diagnosis, prognosis, staging, or monitoring, (2) the determination of drug treatment efficacy, and (3) the stratification of patient populations into risk groups. However, many studies remain biased at the discovery phases because of the overall study design or analysis method. In addition, few studies carefully validate novel genomic biomarkers through functional studies or demonstrate the practicality of the biomarker in question.

This Special Issue aims to present cutting-edge methods that address current limitations at the discovery and validation phases of genomic profiling.  We are especially interested in articles involving novel software or statistical methods, interdisciplinary and collaborative work, multi-omics, integration with imaging, and new genomic profiling technology. Methods that repurpose published data in innovative ways, as well as methods that make genomic profiling more accessible, are also strongly encouraged.

Prof. Paul Spellman
Dr. Sebnem Ece Eksi
Dr. Josiah T. Wagner
Guest Editors

Manuscript Submission Information

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