Special Issue "Genomic Profiling for Biomarker Discovery and Validation"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Technologies and Resources for Genetics".

Deadline for manuscript submissions: 15 March 2019

Special Issue Editors

Guest Editor
Prof. Paul Spellman

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon 97201, USA
Website | E-Mail
Interests: cancer genomics; cancer early detection; biomarkers of outcome
Guest Editor
Dr. Sebnem Ece Eksi

CEDAR, Oregon Health & Science University, Portland, Oregon 97201, USA
Website | E-Mail
Interests: single cell profiling; early detection of prostate cancer; gene regulatory networks; tumor heterogeneity
Guest Editor
Dr. Josiah T. Wagner

CEDAR, Oregon Health & Science University, Portland, Oregon 97201, USA
Website | E-Mail
Interests: mitochondrial biology; developmental biology; molecular diagnostics; functional genomics

Special Issue Information

Dear Colleagues,

Due to the constantly decreasing cost of high-throughput genomic technologies, we are beginning to appreciate the breadth of information we can learn from genomic profiling. For example, genomic profiling can reveal the timing of aberrations that occur as a disease develops and the spatial heterogeneity within a tissue, person, or population. Genomic biomarkers have become valuable tools for (1) disease diagnosis, prognosis, staging, or monitoring, (2) the determination of drug treatment efficacy, and (3) the stratification of patient populations into risk groups. However, many studies remain biased at the discovery phases because of the overall study design or analysis method. In addition, few studies carefully validate novel genomic biomarkers through functional studies or demonstrate the practicality of the biomarker in question.

This Special Issue aims to present cutting-edge methods that address current limitations at the discovery and validation phases of genomic profiling.  We are especially interested in articles involving novel software or statistical methods, interdisciplinary and collaborative work, multi-omics, integration with imaging, and new genomic profiling technology. Methods that repurpose published data in innovative ways, as well as methods that make genomic profiling more accessible, are also strongly encouraged.

Prof. Paul Spellman
Dr. Sebnem Ece Eksi
Dr. Josiah T. Wagner
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • integrative genomics
  • genomic profiling
  • precision medicine
  • genomic-based diagnostics
  • biomarker discovery
  • biomarker validation
  • reproducibility
  • genomic heterogeneity
  • multi-omics

Published Papers

This special issue is now open for submission.
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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