Gel-Based Materials for Cartilage Regeneration

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: 30 July 2026 | Viewed by 1294

Special Issue Editors


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Guest Editor
Department of Internal Medicine III, Cardiology and Angiology, Medical University Innsbruck, 6020 Innsbruck, Austria
Interests: regenerative medicine; tissue engineering; regenerative orthopaedics; regenerative cardiovascular medicine; gels

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Guest Editor
Center for Regenerative Medicine, Department for Health Sciences, Medicine and Research, University for Continuing Education Krems, 3500 Krems, Austria
Interests: osteoarthrits; cartilage regeneration; tissue engineering; OA treatment; viscosupplementation and blood-derived products; gels
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Interests: skeletal regeneration; hydrogels; cell based therapy; tissue engineering
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Special Issue Information

Dear Colleagues,

Cartilage injuries, which are associated with profound clinical implications, represent one of the most formidable challenges in regenerative medicine. The intrinsic inability of cartilage to heal itself necessitates the pursuit of groundbreaking solutions. In this context, gel-based materials stand at the forefront of innovation, offering unparalleled capacities to replicate the intricate architecture and biomechanical properties of native cartilage. With their remarkable biocompatibility and tunable biodegradability, these materials present an elegant solution to a complex biological dilemma.

This Special Issue seeks to illuminate the most recent advancements in gel-based strategies for cartilage regeneration, fostering a deeper understanding of their mechanisms and applications. We will explore pioneering efforts in the development of injectable hydrogels, architecturally sophisticated biomimetic scaffolds, and the strategic incorporation of bioactive molecules that accelerate healing.

The scope of this Special Issue includes, but is not limited to, the following topics:

  • Hydrogels: Ingeniously designed to recapitulate the functional intricacies of cartilage, providing both mechanical integrity and a conducive cellular environment.
  • Injectable Gels: Enabling minimally invasive administration, thereby reducing patient burden and enhancing therapeutic precision.
  • Natural vs. Synthetic Gels: A comparative analysis aimed at optimizing the synergy between biocompatibility and mechanical robustness.
  • Advanced Fabrication Techniques: Leveraging state-of-the-art methodologies such as 3D bioprinting and electrospinning to construct intricately tailored scaffolds.
  • Bioactive Molecules: Harnessing the power of growth factors, cytokines, and ECM components to potentiate regenerative outcomes.
  • Clinical Translation: Bridging the gap from bench to bedside, with insights from ongoing clinical trials and translational research.

We invite the global scientific community to contribute original research articles, comprehensive reviews, and case studies that advance the field of cartilage tissue engineering. Together, we can unravel the complexities of cartilage regeneration and aid in the development of transformative therapies.

Dr. Vivek Jeyakumar
Dr. Christoph Bauer
Dr. Chao Wan
Guest Editors

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Keywords

  • cartilage regeneration
  • hydrogels
  • injectable gels
  • biomaterials
  • tissue engineering
  • bioactive molecules
  • 3D bioprinting
  • anti-inflammatory agents

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Published Papers (1 paper)

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Research

22 pages, 8225 KB  
Article
Migration and Chondrogenesis of Cells from Minced Nasal Cartilage in Type I Collagen Hydrogel: A Workflow for One-Step Engineering of Injectable Grafts
by Alexander Gensch, Atharva Damle, Orhan Sonsöz, Diana Mock, Martin Haug, Davide Adamo, Ewelina M. Bartoszek, Gyözö Lehoczky, Ivan Martin and Andrea Barbero
Gels 2026, 12(3), 190; https://doi.org/10.3390/gels12030190 - 25 Feb 2026
Viewed by 816
Abstract
Articular cartilage (AC) damage heals poorly and can progress to osteoarthritis. Implantation of AC fragments (Minced Cartilage Implantation, MCI) is a promising one-step repair technique but is constrained by the limited availability of healthy AC. In this study, we evaluated the feasibility of [...] Read more.
Articular cartilage (AC) damage heals poorly and can progress to osteoarthritis. Implantation of AC fragments (Minced Cartilage Implantation, MCI) is a promising one-step repair technique but is constrained by the limited availability of healthy AC. In this study, we evaluated the feasibility of MCI using nasal septal cartilage (NSC) as an alternative source of hyaline tissue with strong regenerative capacity. NSC obtained from rhinoplasties was decontaminated using a novel protocol, minced with or without Poloxamer 188 (P188), embedded in collagen I gel (0.5 mL per sample), and cultured for 42 days in platelet-rich plasma (PRP)-supplemented medium. The decontamination procedure with a combination of antibiotics was effective and did not impair cell viability. Histology of the resulting constructs confirmed robust cellular outgrowth and matrix deposition. Tissues produced from NSC and fragmented with P188 contained more cartilaginous matrix than those from NSC fragmented without P188 and those from AC fragmented with P188. NSC fragments embedded in a 1 mL hydrogel, sufficient for clinically relevant defect volumes, also demonstrated strong outgrowth and satisfactory matrix formation. Overall, the developed protocol supports the use of NSC as a viable tissue source in gel-based, injectable MCI grafts for focal cartilage repair. Full article
(This article belongs to the Special Issue Gel-Based Materials for Cartilage Regeneration)
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