Designing Gels for Wound Dressing (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 1232

Special Issue Editor


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Guest Editor
School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan-si 38541, Gyeongsangbuk-do, Republic of Korea
Interests: nanobiotechnology; tissue engineering; nanomaterials; nanofabrication; microbiology; molecular biology; protein chemistry
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Special Issue Information

Dear Colleagues,

Currently, healthcare is facing a growing problem of traumatic wounds causing death. Skin is the major external defense system that protects the body from microbial infections and external environmental stressors. In developing countries, >90% of accidents cause skin injuries and subsequent deaths yearly. Molecules controlling inflammation and tissue repair are often associated with wound healing, and these factors’ dysregulation leads to mortality in wounded patients. To promote wound healing and skin tissue repair, effective wound dressing materials are active supplements to overcome the limitations of natural wound repair processes and to avoid scar formation. Hydrogels can be used as an active wound dressing material to enhance the repair process by maintaining optimal conditions for wound healing. The advantages of hydrogel dressings over conventional dressings are numerous. A topical application can help remove infected and necrotic tissue from dry wounds, scabs, and necrotic wounds and keep them clean. 

Designing hydrogels with spatiotemporal regulation in the drug release for the wound-healing process is critical in wound management. As a multidisciplinary topic, this Special Issue will assist chemists, material scientists, engineers, and medical practitioners in understanding the benefits and limitations of hydrogels to build and create therapeutically beneficial biomaterial platforms for translational applications. It can also bring out the recent advances and novel methodologies in designing and developing active hydrogels to treat and heal wounds for cost-effective treatment. Furthermore, this field invites research on innovative functionalization chemistries, variable combinations/compositions of natural and synthetic hydrogels, introducing natural therapies, creating dynamic crosslinking chemistries, and fabricating multi-modal and intelligent hydrogels for wound management.

We gladly receive research and review articles relevant to the topics below, and other highly significant articles closely related to these topics are also welcome.

  • Novel crosslinking methods in designing hydrogels; 
  • Three-dimensional/four-dimensional-printed hydrogels for wound healing; 
  • Antibacterial hydrogels in wound dressing;
  • Biopolymer-based hydrogels in wound healing;
  • Metal nanocomposite hydrogels for wound healing;
  • Hydrogels for controlled drug delivery; 
  • Self-healing hydrogels for wound management;
  • Smart responsive hydrogels for specific wound healing;
  • Functional hydrogels for wound healing. 

Dr. Kannan Badri Narayanan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogels
  • biopolymers
  • nanocomposite
  • antibacterial
  • wound healing
  • wound dressing
  • wound management

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Published Papers (1 paper)

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23 pages, 1356 KiB  
Review
Enhancing Wound Healing Through Secretome-Loaded 3D-Printed Biomaterials
by Tithteeya Rattanachot, Yogeswaran Lokanathan, Mh Busra Fauzi and Manira Maarof
Gels 2025, 11(7), 476; https://doi.org/10.3390/gels11070476 - 20 Jun 2025
Viewed by 1095
Abstract
Wound healing remains a significant hurdle within the field of medical practice, especially concerning chronic and non-healing injuries. Conventional interventions, such as skin grafts, wound dressings, and biomaterials, offer structural support for the regenerated tissues but often lack the biological signaling cues essential [...] Read more.
Wound healing remains a significant hurdle within the field of medical practice, especially concerning chronic and non-healing injuries. Conventional interventions, such as skin grafts, wound dressings, and biomaterials, offer structural support for the regenerated tissues but often lack the biological signaling cues essential for tissue regeneration. However, these approaches often lack the biological signals necessary to promote effective tissue repair. An emerging strategy involves incorporating cell-secreted proteins, known as the secretome, into biomaterials. The secretome contains bioactive elements such as cytokines, growth factors, and extracellular vesicles (EVs), which enhance the wound healing process. This review explores the potential of secretome-loaded biomaterials in modulating inflammation, promoting angiogenesis, and assisting in the remodeling of the extracellular matrix (ECM). Recent advancements in biomaterial engineering technology, such as 3-dimensional (3D) bioprinting, have improved the controlled delivery and bioactivity of secretome at the wound site. These gel-based biomaterials enhance wound healing by providing sustained bioactive molecule release, improving cell growth, and tissue repair. Despite these promising outcomes, limitations including variations in secretome composition and difficulties in large-scale production. Hence, secretome-loaded biomaterials offer a promising solution for wound healing, but further research is needed to optimize formulations, ensure stability, and validate clinical applications. Full article
(This article belongs to the Special Issue Designing Gels for Wound Dressing (2nd Edition))
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