Antimicrobial Hydrogels (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: closed (10 April 2024) | Viewed by 3818

Special Issue Editors

MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
Interests: hydrogels; biomaterials; bioprinting; microfluidics; wound dressing; tissue engineering
Special Issues, Collections and Topics in MDPI journals
College of Light Industry and Textile, Qiqihar University, Qiqihar 161000, China
Interests: hydrogel; cellulose; 3D bioprinting; wound dressing; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to all authors, reviewers, and readers for their responses to the first Edition of our Special Issue on “Antimicrobial Hydrogels”. You can access these articles for free via the link:

https://www.mdpi.com/journal/gels/special_issues/Antimicrobial_Hydrogels

This Special Issue on “Antimicrobial Hydrogels” is dedicated to recent developments in the field, from theoretical and fundamental aspects to the synthesis, characterization, and applications of antimicrobial hydrogels. Within this context, a broad range of subjects, including the materials, structure, manufacture technology, theory and applications, will be discussed.

Hydrogel is a kind of polymer with a three-dimensional network structure, which can keep its original structure without being dissolved after swelling. Hydrogels can be formed by the copolymerization of different hydrophilic and hydrophobic monomers. Due to their good biocompatibility, hydrogels are widely used as excellent biomedical materials, such as drug carriers, tissue scaffolds, and wound dressings which can maintain a moist environment and are useful for sustained drug delivery for wound repair and act as a barrier against exogenous bacteria. Hydrogels are used in combination with different types of antibiotics to accelerate wound healing. As such, there is wide interest in antibacterial hydrogels because of their hydrogel and antibacterial performance.

Therefore, this Special Issue of Gels, “Antimicrobial Hydrogels”, serves to provide a platform for researchers to report the recent advances in antimicrobial hydrogels and antimicrobial hydrogel-based composites.

Dr. Feng Cheng
Dr. Hongbin Li
Guest Editors

Manuscript Submission Information

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Keywords

  • hydrogel
  • antibacterial
  • synthesis and characterization
  • wound dressing
  • tissue engineering

Published Papers (3 papers)

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Research

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14 pages, 10681 KiB  
Article
The Effects of Pectin–Honey Hydrogel in a Contaminated Chronic Hernia Model in Rats
by Anna Cerullo, Gessica Giusto, Lorella Maniscalco, Patrizia Nebbia, Mitzy Mauthe von Degerfeld, Matteo Serpieri, Cristina Vercelli and Marco Gandini
Gels 2023, 9(10), 811; https://doi.org/10.3390/gels9100811 - 11 Oct 2023
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Abstract
Incisional hernia is a frequent complication after abdominal surgery. A previous study on rats evaluated the use of a Pectin–Honey Hydrogel (PHH)-coated polypropylene (PP) mesh for the healing of acute hernias. However, there are no studies investigating the use of PHH in association [...] Read more.
Incisional hernia is a frequent complication after abdominal surgery. A previous study on rats evaluated the use of a Pectin–Honey Hydrogel (PHH)-coated polypropylene (PP) mesh for the healing of acute hernias. However, there are no studies investigating the use of PHH in association with PP mesh in chronic contaminated hernia. The aims of this study are to assess the effectiveness of PHH in promoting abdominal hernia repaired with PP mesh and in counteracting infection. Twenty Sprague Dawley male rats were enrolled and a full thickness defect was made in the abdominal wall. The defect was repaired after 28 days using a PP mesh, and a culture medium (Tryptone Soy Broth, Oxoid) was spread onto the mesh to contaminate wounds in both groups. The rats were randomly assigned to a treated or untreated group. In the treated group, a PHH was applied on the mesh before skin closure. At euthanasia—14 days after surgery—macroscopical, microbiological and histopathological evaluations were performed, with a score attributed for signs of inflammation. An immunohistochemical investigation against COX-2 was also performed. Adhesions were more severe (p = 0.0014) and extended (p = 0.0021) in the untreated group. Bacteriological results were not significantly different between groups. Both groups showed moderate to severe values (score > 2) in terms of reparative and inflammatory reactions at histopathological levels. The use of PHH in association with PP mesh could reduce adhesion formation, extension and severity compared to PP mesh alone. No differences in terms of wound healing, contamination and grade of inflammation were reported between groups. Full article
(This article belongs to the Special Issue Antimicrobial Hydrogels (2nd Edition))
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14 pages, 1569 KiB  
Article
Intravaginal Gel for Sustained Delivery of Occidiofungin and Long-Lasting Antifungal Effects
by Andrew Cothrell, Kevin Cao, Rachele Bonasera, Abraham Tenorio, Ravi Orugunty and Leif Smith
Gels 2023, 9(10), 787; https://doi.org/10.3390/gels9100787 - 29 Sep 2023
Viewed by 791
Abstract
Fungal infections are caused by opportunistic pathogens that can be life threatening or debilitating. Candida spp. are becoming increasingly resistant to current clinically approved antifungal therapeutics. Candida infections afflict not only immunosuppressed but also immunocompetent individuals. Recurrent vulvovaginal candidiasis (RVVC) is a disease [...] Read more.
Fungal infections are caused by opportunistic pathogens that can be life threatening or debilitating. Candida spp. are becoming increasingly resistant to current clinically approved antifungal therapeutics. Candida infections afflict not only immunosuppressed but also immunocompetent individuals. Recurrent vulvovaginal candidiasis (RVVC) is a disease that afflicts 5–9% of women. Occidiofungin is a novel cyclic peptide that has a broad spectrum of antifungal activity with a novel fungicidal mechanism of action. A gel formulation containing occidiofungin (OCF001) is being developed for use to treat vulvovaginal candidiasis. The formulated gel for intravaginal application used hydroxyethyl cellulose as the primary gelling agent and hydroxypropyl β-cyclodextrin as a solubilizing agent for occidiofungin. Franz cells and LC-MS/MS were used to determine the rate of drug substance diffusion in the gel formulation. The formulation was tested in an ex vivo mouse skin efficacy study, and the safety was tested following repeat intravaginal administration in rabbits. In this study, the gel formulation was shown to reduce the drug substance rate of diffusion across a skin memetic membrane. The study showed that the formulation extends exposure time to inhibitory concentrations of occidiofungin over a 24-h period and supports a single daily application for the treatment of RVVC. Full article
(This article belongs to the Special Issue Antimicrobial Hydrogels (2nd Edition))
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Review

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23 pages, 4763 KiB  
Review
The Recent Progress of the Cellulose-Based Antibacterial Hydrogel
by Ying Sun, Jiayi Wang, Duanxin Li and Feng Cheng
Gels 2024, 10(2), 109; https://doi.org/10.3390/gels10020109 - 29 Jan 2024
Cited by 1 | Viewed by 1668
Abstract
Cellulose-based antibacterial hydrogel has good biocompatibility, antibacterial performance, biodegradability, and other characteristics. It can be very compatible with human tissues and degradation, while its good water absorption and moisturizing properties can effectively absorb wound exudates, keep the wound moist, and promote wound healing. [...] Read more.
Cellulose-based antibacterial hydrogel has good biocompatibility, antibacterial performance, biodegradability, and other characteristics. It can be very compatible with human tissues and degradation, while its good water absorption and moisturizing properties can effectively absorb wound exudates, keep the wound moist, and promote wound healing. In this paper, the structural properties, and physical and chemical cross-linking preparation methods of cellulose-based antibacterial hydrogels were discussed in detail, and the application of cellulose-based hydrogels in the antibacterial field was deeply studied. In general, cellulose-based antibacterial hydrogels, as a new type of biomaterial, have shown good potential in antimicrobial properties and have been widely used. However, there are still some challenges, such as optimizing the preparation process and performance parameters, improving the antibacterial and physical properties, broadening the application range, and evaluating safety. However, with the deepening of research and technological progress, it is believed that cellulose-based antibacterial hydrogels will be applied and developed in more fields in the future. Full article
(This article belongs to the Special Issue Antimicrobial Hydrogels (2nd Edition))
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