Polymer-Based Hydrogels Applied in Drug Delivery

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1209

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10 000 Zagreb, Croatia
Interests: in situ gelling system; nasal drug delivery; dermal drug delivery; hydrogels; spray drying; microspheres; mucoadhesion; rheology

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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10 000 Zagreb, Croatia
Interests: cyclodextrins; solubility; controlled release; oromucosal drug delivery; spray drying; mucoadhesion
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Special Issue Information

Dear Colleagues,

Hydrogels have gathered significant attention across a wide array of scientific disciplines, demonstrating their versatility and potential in numerous applications. They highlight a prospective area, with a constant increase in the number of articles describing innovative research. As a result, we are excited to announce the Special Issue titled "Polymer-Based Hydrogels Applied in Drug Delivery".

This Special Issue aims to highlight the most novel advancements in drug delivery systems formulated as hydrogels. The focus will be on innovations in the design of hydrogel-based formulations as well as the methods for their characterization. The developed hydrogels may be designed for all of the drug delivery routes, including ophthalmic, nasal, buccal, sublingual, oral, pulmonary, and vaginal routes, and may contain various polymers, both synthetic and from natural sources. Contributions addressing composite and hybrid systems as well as nanogels, in situ gels, and powder systems that gel at the site of application are highly anticipated.

We particularly encourage submissions that investigate novel aspects of hydrogel performance, with a focus on optimizing administration, enhancing safety profiles, and improving targeted drug delivery.

We believe that this Special Issue will serve as an important resource for researchers striving to advance the fields of pharmaceutics and hydrogel science. We cordially invite you to submit your original research articles and review papers for consideration.

Dr. Laura Nižić Nodilo
Prof. Dr. Mario Jug
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • polymer-based hydrogel
  • controlled drug release
  • targeted drug delivery
  • rheological characterization
  • viscoelastic systems
  • texture analysis
  • biocompatibility
  • muco-adhesion
  • natural polymers
  • novel (multi)functional polymers

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Published Papers (1 paper)

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Research

24 pages, 2480 KiB  
Article
Development and Characterization of In Situ Gelling Nasal Cilostazol Spanlastics
by Maryana Salamah, Mária Budai-Szűcs, Bence Sipos, Balázs Volk, Gábor Katona, György Tibor Balogh and Ildikó Csóka
Gels 2025, 11(2), 82; https://doi.org/10.3390/gels11020082 - 22 Jan 2025
Cited by 1 | Viewed by 938
Abstract
Cilostazol (CIL), a BCS class II antiplatelet aggregation and vasodilator agent, is used for cerebrovascular diseases to minimize blood–brain barrier dysfunction, white matter-lesion formation, and motor deficits. The current work aimed to develop and optimize cilostazol-loaded spanlastics (CIL-SPA) for nose-to-brain delivery to overcome [...] Read more.
Cilostazol (CIL), a BCS class II antiplatelet aggregation and vasodilator agent, is used for cerebrovascular diseases to minimize blood–brain barrier dysfunction, white matter-lesion formation, and motor deficits. The current work aimed to develop and optimize cilostazol-loaded spanlastics (CIL-SPA) for nose-to-brain delivery to overcome the low solubility and absorption, the first pass-metabolism, and the adverse effects. The optimal CIL-SPA formulation was loaded into Phytagel® (SPA-PG), Poloxamer-407 (SPA-P407), and chitosan (SPA-CS) gel bases and characterized in terms of colloidal properties, encapsulation efficiency (EE%), mucoadhesive properties, and biopharmaceutical aspects. The developed in situ gelling formulations showed a <300 nm average hydrodynamic diameter, <0.5 polydispersity index, and >|±30| mV zeta potential with a high EE% (>99%). All formulations met the droplet size-distribution criteria of nasal requirements (<200 µm), and all formulations showed adequate mucoadhesion properties. Both the BBB-PAMPA and horizontal permeability study through an artificial membrane revealed that all formulations had higher CIL flux and cumulative permeability at in vitro nose-to-brain conditions compared to the initial CIL. The in vitro drug-release study showed that all formulations released ca. 100% of CIL after 2 h. Therefore, the developed formulations could be promising for improving the low bioavailability of CIL through nose-to-brain delivery. Full article
(This article belongs to the Special Issue Polymer-Based Hydrogels Applied in Drug Delivery)
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