Application of In Vitro Digestion Models in Food Nutritional Assessment
A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".
Deadline for manuscript submissions: 4 May 2026 | Viewed by 35
Special Issue Editor
Special Issue Information
Dear Colleagues,
Assessing the nutritional quality and functional effects of foods is not limited to simply measuring their composition; it also requires understanding how nutrients are released, transformed, and absorbed in relation to the glycemic index during digestion. In vitro digestion models offer a practical approach for exploring nutrient behavior beyond compositional analysis and in relation to in vivo studies. These models are now widely used to investigate the bioaccessibility, stability, and interactions of nutrients and bioactive compounds in different food matrices. Compared to in vivo studies, in vitro approaches are more cost-effective, less labor-intensive, and can be conducted without ethical constraints. While they cannot completely replace in vivo experiments, they remain valuable complementary tools for the initial assessment of food behavior and the design of subsequent studies. Static, dynamic, and semi-dynamic models have long been used, and recent developments and the INFOGEST protocol have increased the reliability, reproducibility, and interlaboratory comparability of these models. This Special Issue aims to present recent methodological developments and applications in in vitro digestion models, with particular emphasis on chemical interactions between food components, transformations occurring during digestion, the role of the food matrix and processing, encapsulation strategies to improve nutrient delivery, and their implications for functional food design and nutritional strategies.
Prof. Dr. Osman Sagdic
Guest Editor
Manuscript Submission Information
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Keywords
- in vitro digestion
- bioaccessibility
- nutritional assessment
- food matrix
- INFOGEST
- bioactive compounds
- glycemic index
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