Risk Assessment of Activity, Transformation and Metabolism of Food Constituents and Contaminants

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Quality and Safety".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 281

Special Issue Editors

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Guest Editor
Department of Food and Drug, University of Parma, 43124 Parma, Italy
Interests: food chemistry and toxicology; xenobiotics of food origin; in silico/in vitro approaches; transformation and metabolic fate of food constituents and contaminants; enzyme-based strategies to mitigate food contaminants
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy
Interests: food chemistry; analytical chemistry; mass spectrometry; gas and liquid chromatography; free and masked mycotoxins; food contaminants; food characterization; food flavor; volatile fraction characterization; food contituents modifications; simulated gastro-intestinal digestion
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Foods notoriously include a vast variety of compounds of different origin, ranging to low-molecular-weight molecules to proteins and peptides, which may exert adverse effects on living organisms at many different levels. The list of potentially harmful compounds includes contaminants of both anthropic and natural origin, as well as food constituents which may threaten human health and wellbeing, such as allergens and alkaloids naturally present in certain food matrices used as ingredients and anti-nutritional compounds, to cite but a few. Food processing may also increase the complexity of chemical mixtures in processed foods, possibly extending the number of potentially harmful compounds. In addition, compounds with adverse effects co-occur in food with an equally wide number of health-protecting compounds. The whole chemical complexity is crucial to determine the overall effects on living organisms based on the combined action, such as additive, antagonistic and synergistic effects, that these chemicals are likely to exert on each other.

In this scenario, the risk assessment of food compounds requires i) their precise detection and quantification in various food matrices to provide data for exposure assessment; as well as ii) the investigation of their activity at diverse levels of complexity (i.e., from the molecular level to the whole organism), taking into account the metabolic transformations and those arising from food processing, which may modify the activity/toxicity of parent compounds; and iii) the study of the toxicokinetics and toxicodynamics, being crucial to properly assess the risks to humans.

This Special Issue is intended to collect original research papers, meta-analyses and reviews on those aspects with emphasis on innovative methods (including NAMs—new alternative methodologies) and on the evaluation of emerging threats and mixtures towards effective risk assessment studies.

Dr. Luca Dellafiora
Prof. Dr. Martina Cirlini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • food contaminant
  • food bioactive
  • risk assessment
  • chemical mixture
  • food safety
  • xenobiotic metabolism
  • toxicokinetics
  • toxicodynamics
  • combined action
  • metabolomics

Published Papers

This special issue is now open for submission.
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