Bioactive Polysaccharides in Foods: Novel Sources, Characterization, Activity, and Applications

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Physics and (Bio)Chemistry".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 680

Special Issue Editors


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Guest Editor
Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM, Jiangxi University of Chinese Medicine, Nanchang, China
Interests: structure and functional activity of polysaccharides; intestinal health; gut microbiota; fermentation; synthesis; functional food
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China
Interests: polysaccharide; chromatography carbohydrate; proteins; phytochemicals; nutraceuticals; food science; antioxidants; immunomodulation; gut microbiota; functional food
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive food polysaccharides have emerged as crucial components in the realm of functional foods and nutraceuticals due to their health-promoting activities and relatively low toxicity. A growing number of researchers are increasingly interested in exploring novel resources from sustainable and unconventional sources, such as marine biomass, food processing by-products, novel plant extracts, and microbial fermentation. These novel polysaccharides exhibit superior biological activity due to their unique structural characteristics, including immunomodulatory, antioxidant, prebiotic, and metabolic regulatory effects. These findings suggest that they can be applied in the development of functional foods, nutritional supplements, and bioactive food packaging.

For this Special Issue, authors may submit original research articles and reviews. Topics may include, but are not limited to, novel sources, structure–activity relationships, action mechanisms, and the application of bioactive polysaccharides in food.

Dr. Liuming Xie
Prof. Dr. Jianhua Xie
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive polysaccharides
  • novel sources
  • sustainable ingredients
  • characterization
  • activity
  • structure–activity relationship
  • health benefits
  • applications
  • food technology

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Published Papers (1 paper)

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Research

17 pages, 5314 KB  
Article
Chinese Yam Polysaccharide Alleviates DSS-Induced Ulcerative Colitis After Antibiotic Pretreatment
by Yushun Qian, Fuhao Leng, Yan Yu, Yi Wu, Jiaxin Zhang, Lanlan Cheng, Mingyue Shen and Jianhua Xie
Foods 2026, 15(10), 1633; https://doi.org/10.3390/foods15101633 - 8 May 2026
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Abstract
This study investigated whether the therapeutic efficacy of Chinese yam polysaccharide (CYP) against ulcerative colitis (UC) depends on an intact gut microbiota. A dextran sulfate sodium (DSS)-induced colitis mouse model was established, and one treatment group received broad-spectrum antibiotics (ABXs) before CYP administration [...] Read more.
This study investigated whether the therapeutic efficacy of Chinese yam polysaccharide (CYP) against ulcerative colitis (UC) depends on an intact gut microbiota. A dextran sulfate sodium (DSS)-induced colitis mouse model was established, and one treatment group received broad-spectrum antibiotics (ABXs) before CYP administration to deplete the intestinal microbiota. CYP markedly attenuated colonic injury, reduced disease activity, and suppressed inflammatory mediators under both microbiota-intact and microbiota-depleted conditions. CYP also enhanced intestinal barrier integrity, as evidenced by reduced serum endotoxin levels and increased expression of MUC-2, Claudin-1, Occludin, and ZO-1. In addition, CYP improved hepatic antioxidant status by increasing GSH-Px and catalase activities and decreasing malondialdehyde levels. Moreover, CYP reduced the activation of the NF-κB and MAPK signaling pathways, with similar trends observed under microbiota-depleted conditions. Microbiota profiling showed that CYP partially corrected DSS-induced dysbiosis, whereas the ABX + CYP group exhibited distinct microbial patterns with enrichment of carbohydrate-related metabolic pathways predicted by PICRUSt2. Collectively, these findings suggest that CYP retains protective efficacy after antibiotic pretreatment, indicating that its effects may not be exclusively dependent on gut microbiota modulation, possibly involving direct actions on immune and intestinal epithelial cells. Full article
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