Precision Nutrition Targeting Intestinal Microbiota: Probiotics, Functional Foods, and Human Health

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 736

Special Issue Editors


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Guest Editor
National Marine Food Engineering Technology Research Center, Dalian Polytechnic University, Dalian, China
Interests: intestinal microbes; probiotics and prebiotics; metabolites of probiotics; intestinal barrier; functional foods; probiotics function and nutrition; human health
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Special Issue Information

Dear Colleagues,

The intestinal microbiota plays a critical role in regulating host metabolism, immune homeostasis, and intestinal barrier integrity. Growing evidence indicates that dietary components, including polysaccharides, peptides, polyphenols, probiotics, prebiotics, and other food-derived bioactive substances, can effectively modulate gut microbial composition and metabolic activity, thereby exerting beneficial effects on human health. With advances in microbiome research and nutritional sciences, precision nutrition has emerged as a promising strategy to develop targeted dietary interventions based on individual microbiota profiles and physiological characteristics.

This Special Issue, entitled “Precision Nutrition Targeting Intestinal Microbiota: Probiotics, Functional Foods, and Human Health,” aims to showcase recent progress in microbiota-oriented nutritional research and functional food development. Particular emphasis will be placed on the interactions between food-derived bioactive compounds (such as polysaccharides, peptides, and polyphenols), probiotics and prebiotics, microbial metabolites (postbiotics), and host signaling pathways involved in intestinal barrier function and health regulation.

Original research articles and high-quality reviews involving in vitro, in vivo, and translational studies are welcome. By integrating multidisciplinary insights from food science, nutrition, and microbiology, this Special Issue seeks to advance evidence-based functional foods and precision nutrition strategies targeting gut microbiota to promote human health.

Dr. Xiaomeng Ren
Prof. Dr. Xinping Lin
Guest Editors

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Keywords

  • precision nutrition
  • gut microbiota
  • probiotics and prebiotics
  • functional foods
  • food-derived bioactive compounds
  • polysaccharides
  • peptides and polyphenols
  • intestinal barrier function
  • microbial metabolites (postbiotics)

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Published Papers (1 paper)

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Research

19 pages, 19227 KB  
Article
Larimichthys crocea Swim Bladder Polysaccharides Attenuate 5-Fluorouracil-Induced Intestinal Injury by Modulating the Gut–Metabolic Axis
by Shouhao Zhao, Ruixue Zhao, Donglin Sui, Yixuan Li, Huan Li, Shugang Li, Chunqing Ai, Xueting Bai, Yilin Sha, Jingxian Yan, Wudeng Wang and Xiaomeng Ren
Foods 2026, 15(8), 1425; https://doi.org/10.3390/foods15081425 - 19 Apr 2026
Viewed by 425
Abstract
5-Fluorouracil (5-FU) is a first-line chemotherapeutic agent for solid tumors, but its clinical application is severely limited by dose-dependent intestinal injury that impairs patient quality of life and compromises therapeutic efficacy. Natural polysaccharides, especially marine-derived ones, have become safe and multi-targeted gut-protective candidates [...] Read more.
5-Fluorouracil (5-FU) is a first-line chemotherapeutic agent for solid tumors, but its clinical application is severely limited by dose-dependent intestinal injury that impairs patient quality of life and compromises therapeutic efficacy. Natural polysaccharides, especially marine-derived ones, have become safe and multi-targeted gut-protective candidates due to their excellent biocompatibility and prebiotic-like activities. Larimichthys crocea swim bladder is a characteristic marine biological resource, and its polysaccharides (CIPs) have shown potential bioactivities, yet their protective mechanism against 5-FU-induced intestinal injury remains unclear. Our study explored the protective effects of Larimichthys crocea swim bladder polysaccharides (CIPs) against 5-FU-induced intestinal injury in mice. Following 14-day preventive administration, CIPs alleviated 5-FU-induced body weight loss, diarrhea, colonic shortening, and mucosal injury, and restored goblet cell function. Mechanistically, CIPs enhanced intestinal barrier integrity by upregulating ZO-1, Occludin, and MUC2, suppressed the MyD88/NF-κB pathway to balance inflammatory cytokines, and ameliorated oxidative stress by regulating MDA, GSH, SOD, and CAT. CIPs also restored gut microbial diversity and the Firmicutes/Bacteroidota ratio, and modulated retinol and arginine metabolism. In vitro, CIPs reduced inflammation and oxidative damage in Caco-2 cells and promoted M2 macrophage polarization. Thus, CIPs alleviate 5-FU-induced intestinal injury via multi-targeted regulation of the gut–metabolic axis, showing great potential as a dietary intervention and gut health support agent in food science and oncology nutrition, and boosting the high-value utilization of marine resources. Full article
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