Modification Technologies, Interaction Mechanisms, and Functional Applications of Food-Derived Macromolecules

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Physics and (Bio)Chemistry".

Deadline for manuscript submissions: 10 September 2026 | Viewed by 992

Special Issue Editors


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Guest Editor
School of Food Engineering, Ludong University, Yantai, China
Interests: food-derived macromolecules; modification technologies; interaction mechanisms; bioactive compound delivery; food microbiology

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Guest Editor
School of Life Sciences, Yantai University, Yantai, China
Interests: food protein; physical modification; food additives; functional ingredients; comprehensive utilization; lipid digestion; emulsion process
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State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China
Interests: clean production; comprehensive utilization; biorefinery; functional food additives; biomacromolecules’ modification; bioconversion; green extraction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As known by many, macromolecules derived from food are the core functional components of food systems. These macromolecules play an indispensable role in the nutrition, texture, and encapsulation of bioactive compounds, serving as the key material basis for the innovative development of the modern food industry. However, natural food-derived macromolecules often exhibit inherent limitations, such as poor solubility, insufficient emulsifying stability, and weak acid–base tolerance. These limitations significantly restrict their applications in high-end food products, functional foods, and green additives. Employing precise modification techniques to optimize their structure and function, as well as comprehensively understanding their interaction mechanisms in complex systems, is significant for realizing the full potential of food-derived macromolecules. This Special Issue focuses on cutting-edge research regarding modification techniques, interaction mechanisms, and functional applications of food-derived macromolecules. It aims to promote interdisciplinary innovation, transform the functional limitations of natural macromolecules into application advantages, and provide theoretical and technical support for the sustainable development of the food industry. By bridging the gap between fundamental research and industrial applications, this Special Issue will serve as a platform for researchers to disseminate new discoveries and advance more efficient, sustainable, and high-value utilization of food-derived macromolecules in this field.

Therefore, the primary objective of this Special Issue is to achieve efficient utilization and high-value development of food-derived macromolecules through academic exchange and knowledge translation, with emphasis on the following research areas (including but not limited to):

  • Novel physical modification techniques;
  • Sustainable chemical modification strategies;
  • Biological modification approaches and structure–function relationships;
  • Mechanistic studies of macromolecule–macromolecule interactions;
  • Macromolecule–small molecule interactions;
  • Functional applications of modified macromolecules in food emulsification, stabilization, gelation, and thickening;
  • Design and development of bioactive compound delivery systems;
  • Research and development of functional foods, plant-based alternatives, and low-fat/gluten-free products.

Dr. Bin Liang
Dr. Chanchan Sun
Dr. Wenjie Sui
Guest Editors

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Keywords

  • food-derived macromolecules
  • modification technologies
  • interaction mechanisms
  • structure–activity relationships
  • bioactive compound delivery
  • food additives
  • functional foods

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Published Papers (2 papers)

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Research

14 pages, 3261 KB  
Article
Identification and Antioxidant Characterization of Caffeic Acid–Cysteine Adduct in Meat Products Supplemented with Dandelion Extract
by Xiaohan Li, Fengtao Xiang, Shaobing Ye, Yinhong Chen, Hao Sun and Changbo Tang
Foods 2026, 15(10), 1770; https://doi.org/10.3390/foods15101770 - 17 May 2026
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Abstract
Caffeic acid (CA), a catechol-containing phenolic acid, is readily oxidized to its quinone form during food processing and can form covalent adducts with amino acid residues in proteins. This study aimed to detect the presence of caffeic acid–cysteine adduct (CA-Cys) in meat products [...] Read more.
Caffeic acid (CA), a catechol-containing phenolic acid, is readily oxidized to its quinone form during food processing and can form covalent adducts with amino acid residues in proteins. This study aimed to detect the presence of caffeic acid–cysteine adduct (CA-Cys) in meat products supplemented with dandelion extract, and further investigate its antioxidant properties and intestinal absorption characteristics. Compared with CA, CA-Cys exhibited stronger ABTS radical scavenging activity, greater ferric-ion reducing capability, and lower cytotoxicity in cultured cells. In the oxidative stress model induced by hydrogen peroxide (H2O2) in Caco-2 cells, CA-Cys treatment enhanced antioxidant enzyme activities in a dose-dependent manner. In the Caco-2 cell monolayer model, the apparent permeability coefficient and cellular uptake of CA-Cys were 4.32 × 10−5 cm/s and 0.85 ± 0.14 nmol/mg protein, respectively. These values were approximately 1.23-fold and 1.67-fold higher than those of CA, suggesting that CA-Cys may have significant advantages in intestinal absorption. These results indicate that adducts represent potentially beneficial substances for green food processing. Full article
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19 pages, 2392 KB  
Article
Synergistic Modification of Steam Explosion Combined with Enzymatic Hydrolysis on Wheat Bran to Improve Dough Properties, Bread Quality, and In Vitro Digestibility
by Xiaoxuan Li, Xiaomeng Guo, Jie Yu, Zixin Zhao, Xue Tian, Wenjie Sui, Jing Meng, Tao Wu and Min Zhang
Foods 2026, 15(9), 1465; https://doi.org/10.3390/foods15091465 - 22 Apr 2026
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Abstract
Wheat bran, as a major nutrient-rich agricultural by-product, is underutilized due to poor functional properties. This study investigated the synergistic effects of steam explosion (SE), enzymatic hydrolysis (EH), and SE combined with EH (SE-EH) on wheat bran to improve the dough properties, bread [...] Read more.
Wheat bran, as a major nutrient-rich agricultural by-product, is underutilized due to poor functional properties. This study investigated the synergistic effects of steam explosion (SE), enzymatic hydrolysis (EH), and SE combined with EH (SE-EH) on wheat bran to improve the dough properties, bread quality, and in vitro starch digestion. Results showed that SE destroyed the dense structure of wheat bran to form a porous surface morphology and promoted the conversion of insoluble dietary fiber (IDF) to soluble dietary fiber (SDF). This structural loosening facilitated further fiber degradation for subsequent EH and achieved the obvious improvements in hydration properties after combined treatment. For the dough system, the addition of SE-EH bran increased the water absorption, hardness, and viscosity, but reduced the development and stability time of the dough, in comparison with the control dough. These changes suggested that the modified bran altered dough hydration behavior and gluten network continuity, contributing to the increment of bread’s specific volume. The starch hydrolysis rate of bread adding SE-EH wheat bran was decreased; the slowly digestible starch (SDS) and resistant starch (RS) contents were 2.59-fold and 1.31-fold higher than the control group, respectively. Additionally, the incorporation of modified wheat bran delayed bread hardening during storage, with the SE-modified group showing the best effect. Wheat bran modification enhanced its processing functionality, providing a feasible approach for bread production to improve storage stability and nutritional quality. Full article
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