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Application of Chromatography and Mass Spectrometry in Food Safety Monitoring

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Analytical Methods".

Deadline for manuscript submissions: closed (12 September 2025) | Viewed by 1548

Special Issue Editors


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REQUIMTE/LAQV, Instituto Superior de Engenharia do Porto, Politécnico do Porto, 4249-015 Porto, Portugal
Interests: antioxidants; endocrine disruptors; fatty acids, food safety; lipid oxidation; One Health
Special Issues, Collections and Topics in MDPI journals
REQUIMTE/LAQV, ISEP, Polytechnic of Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal
Interests: analytical chemistry; food safety; gas chromatography; public and environmental health; OneHealth; quality control
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

Chromatography is a cornerstone analytical technique in food monitoring, critical in ensuring food safety, quality, and regulatory compliance. It is widely used to detect, identify, and quantify various substances, including contaminants, residues, and additives in food products.

Mass spectrometry (MS) enhances analytical capabilities by providing precise molecular weight data and structural information. Gas chromatography (GC) coupled with MS allows for separating and quantifying multiple contaminant residues in food. Liquid chromatography (LC) is equally valuable, especially for compounds that are not volatile or thermally stable, such as mycotoxins and antibiotics.

Chromatographic techniques can identify the presence of unauthorized substances (food fraud and adulteration) or the dilution of high-value ingredients, such as olive oil or honey, with cheaper alternatives.

Overall, the application of chromatography in food monitoring is essential for maintaining food safety, upholding regulatory standards, and ensuring consumer protection, thus allowing for the precise and reliable analysis of complex matrices and supporting the integrity of the global food supply chain.

Prof. Dr. Valentina Fernandes Domingues
Dr. Sara Sousa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chromatography
  • mass spectrometry
  • food
  • pesticides
  • dioxins
  • contaminants
  • residues
  • additives in food
  • mycotoxins
  • plasticizers

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Published Papers (1 paper)

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Research

17 pages, 1633 KB  
Article
High-Throughput Screening and Confirmation of 420 Hazardous Substances in Feed Based on Liquid Chromatography−High-Resolution Mass Spectrometry
by Jie Wang, Xu Gu, Ming Jia, Yunfeng Gao, Peng Wang, Wenlong Du, Qingshi Meng, Jing Li and Donghui Liu
Foods 2026, 15(3), 502; https://doi.org/10.3390/foods15030502 - 1 Feb 2026
Viewed by 810
Abstract
Detection of hazardous substances in feed is important for ensuring human health. A method based on liquid chromatography-high-resolution mass spectrometry (LC-HRMS) was developed and validated for the screening and confirmation of 420 hazardous substances, including pesticides, veterinary drugs, and mycotoxins commonly found in [...] Read more.
Detection of hazardous substances in feed is important for ensuring human health. A method based on liquid chromatography-high-resolution mass spectrometry (LC-HRMS) was developed and validated for the screening and confirmation of 420 hazardous substances, including pesticides, veterinary drugs, and mycotoxins commonly found in feed. The screening phase employed less stringent criteria to minimize false negatives caused by matrix effects. Subsequently, stricter identification criteria were applied for confirmation to avoid false positives from interfering compounds. The performance of the proposed method was verified by limit of detection (LOD, 5~500 μg/L), screening detection limits (SDL, 50~500 μg/L), matrix effect (ME, 36.12~121.16%), precision (0.02~14.98%), stability, and accuracy. The method was successfully applied to real feed samples, demonstrating its capability to detect the presence of the 420 target hazardous substances. We believe our method provides strong technical support for ensuring the quality and safety of feed. Full article
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