Aquatic Animal Diseases and Vaccine Development

A Special Issue of Fishes (ISSN 2410-3888) belonging to the section "Welfare, Health and Disease".

Deadline for manuscript submissions: closed (20 November 2025) | Viewed by 1759

Editor


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Guest Editor
College of Fisheries, Tianjin Agricultural University, Tianjin 300384, China
Interests: bacterial pathogens; fish immunology; interaction of pathogen and host; multiomics
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Special Issue Information

Dear Colleagues,

The global aquaculture industry faces unprecedented challenges from emerging and re-emerging aquatic animal diseases that threaten food security, biodiversity, and economic stability. We recognize the urgent need to advance our understanding of pathogen–host interactions and accelerate vaccine development for sustainable aquatic health management. This Special Issue aims to publish work on research addressing critical gaps in aquatic animal disease mechanisms for pathogenic microorganisms such as fungal, bacterial, and viral infections, etiology, epidemiology, host non-specific immunity and adaptive immune response, molecular cytopathology, fish mucosal immunology, and vaccine application, as well as fish vaccine design and development and innovative disease control strategies.

Prof. Dr. Aijun Lv
Guest Editor

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Keywords

  • aquatic animal diseases
  • etiology
  • epidemiology
  • host immune response
  • vaccine
  • prevention and control

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Published Papers (1 paper)

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Research

26 pages, 3001 KB  
Article
Design, Construction, and Efficacy of a Novel Multiepitope Chimeric Vaccine Against Lumpfish (Cyclopterus lumpus) Infection
by Joy Chukwu-Osazuwa, Trung Cao, Ignacio Vasquez, Hajarooba Gnanagobal, Ahmed Hossain, Oluwatoyin Onireti, Setu Chakraborty, Vimbai Irene Machimbirike and Javier Santander
Fishes 2026, 11(2), 83; https://doi.org/10.3390/fishes11020083 - 30 Jan 2026
Viewed by 1326
Abstract
The development of effective vaccines is a critical step in effective disease management in aquaculture. This study introduces a novel Multiepitope Chimeric Vaccine (MCV) designed to enhance immunity in lumpfish against Vibrio anguillarum, Aeromonas salmonicida, Yersinia ruckeri, Moritella viscosa and [...] Read more.
The development of effective vaccines is a critical step in effective disease management in aquaculture. This study introduces a novel Multiepitope Chimeric Vaccine (MCV) designed to enhance immunity in lumpfish against Vibrio anguillarum, Aeromonas salmonicida, Yersinia ruckeri, Moritella viscosa and Piscirickettsia salmonis. Epitopes from major toxins and virulence factors were selected to construct the MCV in silico. Structural validation showed 96.7% of residues in favored regions, confirming stability. Codon optimization yielded a G+C content of 54.61% and a Codon Adaptation Index (CAI) of 1, indicating strong expression potential in Escherichia coli. Immune simulations predicted robust B- and T-cell responses, suggesting induction of both humoral and cell-mediated immunity. Experimental vaccination of lumpfish (n = 35/group) with E. coli-expressed MCV led to significantly elevated IgM levels at four- and six-weeks post-vaccination (p ≤ 0.05, p ≤ 0.01, respectively). Upon pathogen challenge, vaccinated groups showed delayed mortality against V. anguillarum, A. salmonicida, and P. salmonis, though survival differences were not statistically significant across treatments. These results highlight the immunogenicity potential of the MCV and its capacity to elicit targeted immune responses. However, further optimization is necessary to improve protective efficacy and survival outcomes. This study lays a foundation for the application of multiepitope vaccines in lumpfish aquaculture and supports ongoing efforts toward sustainable disease control strategies. Full article
(This article belongs to the Special Issue Aquatic Animal Diseases and Vaccine Development)
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