Bioactive Metabolites of Bacterial Origin

A special issue of Fermentation (ISSN 2311-5637). This special issue belongs to the section "Microbial Metabolism, Physiology & Genetics".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2394

Special Issue Editors


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Guest Editor
Academy of Biology and Biotechnology, Southern Federal University, Stachki 194/1, 344090 Rostov-on-Don, Russia
Interests: biosensors; bacteria; bacillus; probiotics; quorum-sensing; nonribosomal synthesis
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Guest Editor
Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia
Interests: NRPS; PKS; probiotics; PGPR; antimicrobials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

I would like to invite you to contribute a paper to a Special Issue dedicated to bioactive metabolites of bacterial origin.

This Special Issue will focus on the latest research advances in bioactive metabolites synthesized by bacteria. Bioactive metabolites produced by bacteria are known to exhibit a wide variety of biologically active properties, including antimicrobial, antifungal, anti-inflammatory, and anticancer activities, to name just a few. The discovery of new bioactive metabolites, as well as understanding their mechanisms of action, biosynthesis, and regulation, is of paramount importance for the development of novel drugs and medicine.

This Special Issue aims to provide a platform for experts to share their research and insights on various aspects of bioactive metabolites of bacterial origin. The scope of this Special Issue will cover recent findings in biosynthetic pathways, genomic analysis, identification, and characterization of novel compounds from bacterial sources, as well as the application of advanced biotechnological strategies to explore the potential of bacterial metabolites discovery.

We welcome research articles, review articles, and short communications on this subject, and we look forward to bringing together a collection of high-quality research contributions from around the world, which will stimulate further debate and understanding on the topic.

Dr. Evgenya V. Prazdnova
Dr. Anuj Ranjan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive metabolites
  • bacteria
  • antimicrobials
  • genomics
  • proteomics
  • nonribosomal synthesis
  • anticancer
  • antifungal
  • biotechnological strategies

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Published Papers (1 paper)

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Research

14 pages, 2329 KiB  
Article
Profile of PKS and NRPS Gene Clusters in the Genome of Streptomyces cellostaticus NBRC 12849T
by Hisayuki Komaki and Tomohiko Tamura
Fermentation 2023, 9(11), 924; https://doi.org/10.3390/fermentation9110924 - 24 Oct 2023
Cited by 1 | Viewed by 1570
Abstract
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has the potential to produce diverse polyketides and [...] Read more.
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has the potential to produce diverse polyketides and nonribosomal peptides. Here, we sequenced the whole genome of S. cellostaticus NBRC 12849T and surveyed polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) gene clusters in the genome. The genome encoded 12 PKS, one NRPS and eight hybrid PKS/NRPS gene clusters. Among the 21 gene clusters, products of 10 gene clusters were annotated to be an annimycin congener, fuelimycins, lankamycin, streptovaricin, spore pigment, flaviolin, foxicin, blasticidin, lankacidin and an incarnatapeptine congener via our bioinformatic analysis. Although the other clusters were orphan and their products were unknown, five of them were predicted to be compounds derived from two independent diketides, a tridecaketide, a triketide and a tetraketide with a cysteine residue, respectively. These results suggest that S. cellostaticus is a source of diverse polyketides and hybrid polyketide/nonribosomal peptides, including unknown and new secondary metabolites. Full article
(This article belongs to the Special Issue Bioactive Metabolites of Bacterial Origin)
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