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Cardiovascular Risk Stratification in Hypertension
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Cardiovascular Risk Stratification in Hypertension

A special issue of Diseases (ISSN 2079-9721). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 1 July 2025 | Viewed by 519

Special Issue Editors

Dr. Giulio Geraci

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Guest Editor
Department of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy
Interests: hypertension; atherosclerosis; vascular damage; chronic kidney disease; metabolism
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Mulè

E-Mail Website
Guest Editor
Unit of Nephrology and Dialysis, Hypertension Excellence Centre, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90133 Palermo, Italy
Interests: hypertension; atherosclerosis; insulin resistance; echocardiography; diabetes; blood pressure; internal medicine; cardiovascular medicine; heart failure; myocardial infarction
Special Issues, Collections and Topics in MDPI journals
Dr. Giacomo Pucci

E-Mail Website
Guest Editor
Department of Internal Medicine, University of Perugia, Perugia, Italy
Interests: hypertension; heart failure; atherosclerosis; cardiovascular medicine; clinical cardiology; echocardiography; cardiac function; insulin resistance; internal medicine

Special Issue Information

Dear colleagues,

Hypertension is the leading modifiable factor associated with stroke, coronary events, and cardiovascular (CV) death. However, hypertensive patients represent a heterogeneous group with different CV risks due to different organ damage and comorbidities, and both therapeutic options as well as targets change depending on a patient's global CV risk. Therefore, stratifying CV risk as best as possible is essential for predicting prognoses and to personalize target therapies.

We are pleased to invite you to submit an article for this Special Issue, titled “Cardiovascular Risk Stratification in Hypertension”, which will be published in Diseases (IF: 2.9). The main purpose of this Special Issue is to collect the most recent clinical and experimental evidence about new and traditional indices associated with CV risk in hypertensive patients, as well as about the scores used to estimate CV risk. In particular, considerable relevance will be given to the new genetic, molecular, clinical, and instrumental indices or markers that could improve the stratification of cardiovascular risk in hypertensive individuals.

In this Special Issue, original research articles and reviews are welcome.

I look forward to receiving your contributions.

Dr. Giulio Geraci
Dr. Giuseppe Mulè
Dr. Giacomo Pucci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diseases is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypertension
  • cardiovascular risk
  • cardiovascular death
  • risk score
  • organ damage

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Published Papers (1 paper)

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Research

12 pages, 1185 KiB  
Article
Relationships of Isolated Nocturnal Hypertension with Glomerular Filtration Rate and Albuminuria
by Caterina Carollo, Giulio Geraci, Alessandra Sorce, Raffaella Morreale Bubella, Emanuele Cirafici, Maria Elena Ciuppa, Salvatore Evola and Giuseppe Mulè
Diseases 2025, 13(4), 107; https://doi.org/10.3390/diseases13040107 - 2 Apr 2025
Viewed by 231
Abstract
Background/Objectives: Isolated nocturnal hypertension (INH) represents a unique phenotype that can only be identified through ambulatory blood pressure monitoring (ABPM). An increasing body of evidence suggests a significant association between INH and heightened cardiovascular morbidity, mortality, and, more recently, kidney disease progression. Considering [...] Read more.
Background/Objectives: Isolated nocturnal hypertension (INH) represents a unique phenotype that can only be identified through ambulatory blood pressure monitoring (ABPM). An increasing body of evidence suggests a significant association between INH and heightened cardiovascular morbidity, mortality, and, more recently, kidney disease progression. Considering these findings, this study aims to retrospectively assess the prevalence of INH and its relationship with glomerular filtration rate (GFR) and albumin excretion rate (AER) in a large cohort of hypertensive patients. Methods: A total of 1340 subjects selected from the patients of our European Hypertension Excellence Centre of the University of Palermo were enrolled. Biochemical tests, urinalysis, 24 h ambulatory blood pressure monitoring, and collection of anamnestic and anthropometric data were performed on each patient. Results: In our cohort, the prevalence of INH was 11%. Logistic regression analyses revealed that male sex, AER, and eGFR were significantly associated with the INH phenotype. AER ≥ 5.8 µg/min predicted the presence of INH with 73.7% sensitivity and 58.4% specificity. An eGFR < 60 mL/min/1.73 m2 was also correlated with INH, although its predictive value was less prominent. Multivariable regression models confirmed that AER and eGFR, along with male sex, were independent predictors of INH. In patients with normal blood pressure, AER and metabolic syndrome were also associated with INH. CKD (AER < 30 mg/day and eGFR < 60 mL/min/1.73 m2) was significantly linked to INH. Conclusions: Our research confirms the direct relationship between AER and INH and the inverse relationship between GFR and INH, thus underlining the leading role of renal function in the onset of INH, as widely observed in the literature. The confirmed association between renal markers and INH in the subgroup of subjects with a clinically normal blood pressure could help us to identify the subjects who should undergo ABPM. Full article
(This article belongs to the Special Issue Cardiovascular Risk Stratification in Hypertension)
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