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Feature Papers in Section 'Cardiology' in 2024–2025
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Feature Papers in Section 'Cardiology' in 2024–2025

A special issue of Diseases (ISSN 2079-9721). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 2255

Special Issue Editor

Prof. Dr. Carl J. Lavie

grade E-Mail Website
Guest Editor
1. Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
2. Ochsner Clinical School, The University of Queensland Medical School, New Orleans, LA 70121, USA
Interests: ardiac rehabilitation and preventive cardiology; impact of physical activity and fitness on obesity and obesity paradox; COVID-19
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Cardiology section offers an open forum to present either innovative investigations or new insights into cardiovascular disease’s open questions, eventually leading to significant contributions in the understanding of key and emerging cardiovascular disease mechanisms from either basic or translational research.

Topics of interest include, but are not limited to, the following:

  • Prevention and screening;
  • Cardiovascular biochemistry;
  • Cardiovascular biophysics;
  • Cellular cardiovascular biology;
  • Molecular cardiovascular biology;
  • Cardiovascular genetics;
  • Cardiovascular pathology;
  • Cardiovascular physiology;
  • Cardiovascular pharmacology and clinical pharmacology;
  • Translational research;
  • Clinical trials;
  • Personalized medicine;
  • Pharmacogenetics.

For this Special Issue, we aimed to collect high-quality papers related to human cardiovascular disease. All submitted articles will undergo a rigorous peer review process to ensure that the highest scientific quality and relevance to the field are ensured.

Thank you for your attention, and we eagerly anticipate receiving your valuable submissions.

Prof. Dr. Carl J. Lavie
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diseases is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular diseases
  • prevention
  • obesity
  • fitness hypertension

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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15 pages, 2190 KiB  
Review
The Efficacy and Safety of Ferric Carboxymaltose in Heart Failure with Reduced Ejection Fraction and Iron Deficiency: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Inderbir Padda, Sneha Annie Sebastian, Daniel Fabian, Yashendra Sethi and Gurpreet Johal
Diseases 2024, 12(12), 339; https://doi.org/10.3390/diseases12120339 - 22 Dec 2024
Viewed by 1809
Abstract
Background: Iron deficiency (ID) often coexists with heart failure (HF), and its prevalence increases with the severity of HF. Intravenous ferric carboxymaltose (FCM) has been associated with improvements in clinical outcomes, functional capacity, and quality of life (QoL) in patients with HF and [...] Read more.
Background: Iron deficiency (ID) often coexists with heart failure (HF), and its prevalence increases with the severity of HF. Intravenous ferric carboxymaltose (FCM) has been associated with improvements in clinical outcomes, functional capacity, and quality of life (QoL) in patients with HF and ID. However, while earlier studies showed favorable results, more recent studies have failed to demonstrate significant improvements in outcomes for patients with heart failure with reduced ejection fraction (HFrEF) and ID. This meta-analysis seeks to provide updated insights into the effectiveness and safety of FCM compared to placebo/standard of care (SoC) among patients with HFrEF and ID/iron deficiency anemia (IDA). Methods: We performed a systematic review and meta-analysis of the literature from inception to December 2023, utilizing databases such as MEDLINE (via PubMed), Google Scholar, the Cochrane Library, ClinicalTrials.gov, and the ScienceDirect portal. A statistical analysis was carried out using RevMan 5.4 with a random-effects model. Dichotomous outcomes were reported as odds ratios (OR), while continuous outcomes were presented as the weighted mean difference (WMD) with corresponding 95% confidence intervals (CI), and heterogeneity was assessed using the I2 test. Results: The final analysis included data from six randomized controlled trials (RCTs), comprising 5132 patients. Our findings indicate a significant reduction in total HF hospitalizations among patients with HFrEF and ID/IDA treated with FCM compared to those receiving the placebo or SoC, with an OR of 0.59 (95% CI: 0.40 to 0.88, p < 0.010). However, no statistically significant difference was observed in the total number of deaths between the FCM and placebo/SoC groups (OR: 0.85; 95% CI: 0.70 to 1.03, p = 0.09), non-HF hospitalizations (OR: 0.71; 95% CI: 0.41 to 1.25, p = 0.24), or the composite outcome of cardiovascular hospitalizations and cardiovascular deaths (OR: 0.65; 95% CI: 0.40 to 1.04, p = 0.07). Regarding functional capacity, as assessed by the change in 6-min walk test (6MWT) distance, no significant improvement was found, with a weighted mean difference (WMD) of 14.03 (95% CI: −10.94 to 38.99, p = 0.27). QoL, measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ) score, also did not show significant enhancement, with a WMD of 3.85 (95% CI: −0.55 to 8.24, p = 0.09). Furthermore, the safety analysis revealed no significant difference in the incidence of serious adverse events between the FCM and placebo/SoC groups, with an OR of 0.73 (95% CI: 0.49 to 1.10, p = 0.13). Conclusions: In patients with HFrEF and IDA, treatment with intravenous FCM significantly lowers the risk of total HF hospitalizations but does not appear to affect functional capacity, QoL, or mortality. Full article
(This article belongs to the Special Issue Feature Papers in Section 'Cardiology' in 2024–2025)
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