Next Article in Journal
Development of Rapid Extraction Method of Mycobacterium avium Subspecies paratuberculosis DNA from Bovine Stool Samples
Previous Article in Journal
Active Matrix Metalloproteinase-8 Point-of-Care (PoC)/Chairside Mouthrinse Test vs. Bleeding on Probing in Diagnosing Subclinical Periodontitis in Adolescents
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle

Very Early Response Evaluation by PET/MR in Patients with Lung Cancer—Timing and Feasibility

1
Dept. of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
2
Dept. of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
3
Dept. of Radiology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
4
Section of Biostatistics, Dept. of Public Health, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
5
PET Centre, School of Biomedical Engineering and Imaging Sciences, Kings College Hospital, Guy’s & St Thomas Hospital, SE1 9RT London, UK
*
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(1), 35; https://doi.org/10.3390/diagnostics9010035
Received: 18 January 2019 / Revised: 17 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Imaging of Early Response in Cancer Management 2019)
  |  
PDF [840 KB, uploaded 26 March 2019]
  |     |  

Abstract

Purpose: With the increasing number of therapy options available for patients with lung cancer, early response evaluation is needed. We performed this pilot study to assess the feasibility of early, repeated Positron emission tomography-magnetic resonance (PET/MR), the impact of timing and the capability for response prediction in lung tumors during chemotherapy. Methods: Patients with stage IV non-small cell lung cancer referred for chemotherapy were prospectively recruited. Fluorine-18-Fluorodeoxyglucose(18F-FDG)-PET/MR scans were performed prior to, during and after the first or second cycle of chemotherapy. Primary tumors were defined on all scans and size, FDG-uptake and apparent diffusion coefficient (ADC) were measured. Early response was described over time and a Standard Linear Mixed Model was applied to analyze changes over time. Results: 45 FDG-PET/MR scans were performed in 11 patients. Whereas the overall changes measured by ADC did not change significantly, there was an overall significant decrease in FDG-uptake from pre to post treatment scans. There was no difference in the FDG-uptake measured 1 or 3 weeks after therapy, but uptake measured 2 weeks after therapy differed from measurements at week 3. Changes measured in patients scanned during the first treatment cycle appeared more pronounced than during the second cycle. Conclusions: This pilot study indicates that response evaluation shortly after initiation of chemotherapy appears concordant with later evaluation and probably more reliable than evaluation midway between cycles. Responses during or after the first cycle of chemotherapy rather than during subsequent cycles are likely to be more readily measured. View Full-Text
Keywords: response evaluation; lung cancer; non-small-cell lung carcinoma (NSCLC); FDG-PET; diffusion weighted magnetic resonance imaging (DW-MRI) response evaluation; lung cancer; non-small-cell lung carcinoma (NSCLC); FDG-PET; diffusion weighted magnetic resonance imaging (DW-MRI)
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Langer, N.H.; Langer, S.W.; Johannesen, H.H.; Hansen, A.E.; Costa, J.; Klausen, T.L.; Forman, J.; Olin, A.; Rasmussen, S.H.; Sørensen, J.B.; Löfgren, J.; Kjær, A.; Fischer, B.M. Very Early Response Evaluation by PET/MR in Patients with Lung Cancer—Timing and Feasibility. Diagnostics 2019, 9, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diagnostics EISSN 2075-4418 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top