Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
3.6
3.6
Journals
Diagnostics
Special Issues
Coronary Artery Disease Imaging
share announcement

Coronary Artery Disease Imaging

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (10 April 2021) | Viewed by 10891

Special Issue Editor

Prof. Dr. Michael Henein

E-Mail Website
Guest Editor
Department of Public Health and Clinical Medical and Heart Center, Umea University, Umea, Sweden
Interests: non-invasive cardiology including valve disease; coronary artery disease; heart failure; cardiovascular imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Coronary artery disease is the most common life-threatening cardiac pathology, and constitutes a significant financial burden on the global economy. Coronary disease has traditionally been diagnosed and managed using electrocardiography, which indirectly reflects myocardial ischemia, rather than the actual arterial disease. Recent technological developments have enabled the direct visualization of the coronary arteries and hence the ability to ascertain the presence, nature, and extent of the disease. Multi-detector CT allows direct imaging of the coronary arterial lumen and wall, hence the easy detection of early disease before complete lumen obstruction develops. This Issue is dedicated to coronary artery imaging in the context of atherosclerosis, and aims to publish a series of novel findings and comprehensive review articles.

Prof. Dr. Michael Henein
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 3333 KiB  
Article
Early Detection of Coronary Artery Disease by Micro-RNA Analysis in Asymptomatic Patients Stratified by Coronary CT Angiography
by Andrew J. Patterson, Minwoo A. Song, David Choe, Daliao Xiao, Gary Foster and Lubo Zhang
Diagnostics 2020, 10(11), 875; https://doi.org/10.3390/diagnostics10110875 - 28 Oct 2020
Cited by 11 | Viewed by 2663
Abstract
Early detection of asymptomatic coronary artery disease (CAD) is essential but underdeveloped. The aim of this study was to assess micro-RNA (miRNA) expression profiles in patients with or without CAD as selected by coronary CT angiography (CTA) and stratified by risk of CAD [...] Read more.
Early detection of asymptomatic coronary artery disease (CAD) is essential but underdeveloped. The aim of this study was to assess micro-RNA (miRNA) expression profiles in patients with or without CAD as selected by coronary CT angiography (CTA) and stratified by risk of CAD as determined by Framingham Risk Score (FRS). In this pilot study, patients were divided into two groups based on the presence or absence of CAD. Disease status was determined by Coronary CTA by identification of atherosclerosis and/or calcified plaque in coronary arteries. There were 16 control subjects and 16 subjects with documented CAD. Groups were then subdivided based on FRS. Pathway-specific microarray profiling of 86 genes using miRNAs isolated from whole peripheral blood was analyzed. MiRNA were differentially expressed in patients with and without CAD and who were stratified on the basis of FRS with miRNA associated with endothelial function, cardiomyocyte protection and inflammatory response (hsa-miR-17-5p, hsa-miR-21-5p, hsa-miR-210-3p, hsa-miR-29b-3p, hsa-miR-7-5p and hsa-miR-99a-5p) consistently upregulated by greater than twofold in groups with CAD. The present study reveals that miRNA expression patterns in whole blood as selected on the basis of coronary CTA and risk scores vary significantly depending on the subject phenotype. Thus, profiling miRNA may improve early detection of CAD. Full article
(This article belongs to the Special Issue Coronary Artery Disease Imaging)
►▼ Show Figures

Figure 1

11 pages, 1816 KiB  
Article
Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease
by Chin-Chuan Chang, Ming-Hui Yang, Chih-Ting Liu, Hsiu-Lan Chu, Chia-Yang Lin, Wei-Jheng Yen, Chao-Yu Chung, Sheng-Yow Ho and Yu-Chang Tyan
Diagnostics 2020, 10(10), 772; https://doi.org/10.3390/diagnostics10100772 - 30 Sep 2020
Cited by 1 | Viewed by 2951
Abstract
This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease [...] Read more.
This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (p = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%. Full article
(This article belongs to the Special Issue Coronary Artery Disease Imaging)
►▼ Show Figures

Graphical abstract

9 pages, 636 KiB  
Article
Added Value of Transluminal Attenuation Gradient to Qualitative CCTA Ischemia Detection as Determined by 13N-ammonia PET Quantitative Myocardial Perfusion
by Andrea Monroy-Gonzalez, Erick Alexanderson-Rosas, Oscar Perez-Orpinel, Magdalena Dobrolinska, Rene Tio, Jan Cees de Groot, Riemer Slart and Niek Prakken
Diagnostics 2020, 10(9), 628; https://doi.org/10.3390/diagnostics10090628 - 24 Aug 2020
Viewed by 2086
Abstract
Transluminal attenuation gradient (TAG) represents the slope of intraluminal contrast that decreases along a coronary vessel during coronary computed tomography angiography (CCTA). The aim of this study was to determine the added value of TAG to qualitative CCTA assessment of significant stenosis (>50%) [...] Read more.
Transluminal attenuation gradient (TAG) represents the slope of intraluminal contrast that decreases along a coronary vessel during coronary computed tomography angiography (CCTA). The aim of this study was to determine the added value of TAG to qualitative CCTA assessment of significant stenosis (>50%) detecting ischemia as determined by stress myocardial blood flow (MBF) or myocardial flow reserve (MFR) measured by positron emission tomography (PET). Individual contributions of TAG, qualitative assessment and the impact of calcium score were also investigated. Methods: We studied 38 consecutive patients that were referred due to suspected or known coronary artery disease (CAD). All patients underwent a two-phase hybrid 13N-ammonia PET/CT and CCTA. Results: TAG and presence of qualitatively assessed significant stenosis, but not calcium score, were associated with stress myocardial blood flow (MBF) and myocardial flow reserve (MFR). The area under the curves (AUC) of the linear predictor model including qualitative assessment and TAG was superior to the AUC of separate qualitative assessment or TAG for the detection of ischemia according to stress MBF (AUCs were: 88% vs. 79% and 77%; p = 0.01 and p = 0.01, respectively). Conclusions: TAG combined with qualitative CCTA assessment improved ischemia detection. Full article
(This article belongs to the Special Issue Coronary Artery Disease Imaging)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 4783 KiB  
Review
Current Role of Computed Tomography in the Evaluation of Acute Coronary Syndrome
by Min Ji Son, Seung Min Yoo, Dongjun Lee, Hwa Yeon Lee, In Sup Song, Eun Ju Chun and Charles S White
Diagnostics 2021, 11(2), 266; https://doi.org/10.3390/diagnostics11020266 - 09 Feb 2021
Cited by 4 | Viewed by 2302
Abstract
This review article provides an overview regarding the role of computed tomography (CT) in the evaluation of acute chest pain (ACP) in the emergency department (ED), focusing on characteristic CT findings. Full article
(This article belongs to the Special Issue Coronary Artery Disease Imaging)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop