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Open AccessArticle

Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease

by Chin-Chuan Chang 1,2,3,4,†, Ming-Hui Yang 5, Chih-Ting Liu 1,†, Hsiu-Lan Chu 1, Chia-Yang Lin 1, Wei-Jheng Yen 1, Chao-Yu Chung 6, Sheng-Yow Ho 7,8,† and Yu-Chang Tyan 9,10,11,12,13,14,15,*
1
Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
2
Department of Electrical Engineering, I-Shou University, Kaohsiung 84001, Taiwan
3
School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
4
Neuroscience Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
5
Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan
6
Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
7
Department of Radiation Oncology, Chi Mei Medical Center, Tainan 71004, Taiwan
8
Graduate Institute of Medical Science, Chang Jung Christian University, Tainan 71101, Taiwan
9
Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
10
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
11
Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan
12
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan
13
Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
14
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
15
Graduate Institute of Animal Vaccine Technology, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally as first author to this work.
Diagnostics 2020, 10(10), 772; https://doi.org/10.3390/diagnostics10100772
Received: 10 August 2020 / Revised: 16 September 2020 / Accepted: 28 September 2020 / Published: 30 September 2020
(This article belongs to the Special Issue Coronary Artery Disease Imaging)
This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (p = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%. View Full-Text
Keywords: stress perfusion deficit; semi-quantitative parameters; thallium-201; myocardial perfusion imaging; coronary artery disease stress perfusion deficit; semi-quantitative parameters; thallium-201; myocardial perfusion imaging; coronary artery disease
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MDPI and ACS Style

Chang, C.-C.; Yang, M.-H.; Liu, C.-T.; Chu, H.-L.; Lin, C.-Y.; Yen, W.-J.; Chung, C.-Y.; Ho, S.-Y.; Tyan, Y.-C. Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease. Diagnostics 2020, 10, 772.

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