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Special Issue "Technical and Clinical Applications on Long-Axial-Field-of-View/Total Body PET-CT"

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A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 4385

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Special Issue Editors

Prof. Dr. Riemer H.J.A. Slart

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Guest Editor

Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: cardiovascular diseases; PET/CT; SPECT/CT; (hybrid) imaging; multimodality imaging
Special Issues, Collections and Topics in MDPI journals

Dr. Joyce van Sluis

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Guest Editor

Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: clinical technology; PET methodology, processing & technology; biomarkers; (pharmacokinetic) quantitative analysis

Prof. Dr. Andor W.J.M. Glaudemans

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Guest Editor

Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: infections; inflammatory diseases; PET/CT; imaging; (tumor)immunology; multimodality imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

PET is widely considered the most sensitive technique available for noninvasively studying physiology, metabolism, and molecular pathways in living human beings. The introduction of total body (TB)-, and long-axial-field-of-view (LAFOV) PET/CT instruments has recently initiated a new and exciting era in medical imaging. Two developments offer the potential to dramatically increase the effective sensitivity of PET. First, by increasing the geometric coverage to encompass the entire body, and a sensitivity increased by a factor up to 40 times for total-body imaging. TB/LAFOV PET/CT will allow accurate assessment of the extent of disease, particularly, including the entire axial and appendicular skeleton. Quantitative global disease assessment provided by this new PET/CT approach will be superior to conventional measurements, which do not reflect overall disease activity. TB/LAFOV PET/CT imaging may have a revolutionary impact on day-to-day practice of medicine and may become the leading imaging modality in the future. This Special Issue aims to present the role of TB/LAFOV PET/CT in the diagnosis and imaged-based therapeutic management of different (non)oncological diseases, large vessel vasculitis, and also with a focus on the technical background and developments in the era of TB/LAFOV PET/CT camera systems and quantification methodology. We encourage authors to submit both technical and clinical studies in this field. Clinical studies may include systematic reviews/meta-analysis, original retrospective studies, and prospective studies.

Prof. Dr. Riemer H.J.A. Slart
Dr. Joyce van Sluis
Prof. Dr. Andor W.J.M. Glaudemans
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

total body PET/CT
LAFOV PET/CT
technical
clinical
tracers

Published Papers (3 papers)

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Research

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Open AccessArticle

Impact of Reduced Image Noise on Deauville Scores in Patients with Lymphoma Scanned on a Long-Axial Field-of-View PET/CT-Scanner

Flemming Littrup Andersen

and

Barbara Malene Fischer

Diagnostics 2023, 13(5), 947; https://doi.org/10.3390/diagnostics13050947 - 02 Mar 2023

Viewed by 1452

Abstract

Background: Total body and long-axial field-of-view (LAFOV) PET/CT represent visionary innovations in imaging enabling either improved image quality, reduction in injected activity–dose or decreased acquisition time. An improved image quality may affect visual scoring systems, including the Deauville score (DS), which is used for clinical assessment of patients with lymphoma. The DS compares SUVmax in residual lymphomas with liver parenchyma, and here we investigate the impact of reduced image noise on the DS in patients with lymphomas scanned on a LAFOV PET/CT. Methods: Sixty-eight patients with lymphoma underwent a whole-body scan on a Biograph Vision Quadra PET/CT-scanner, and images were evaluated visually with regard to DS for three different timeframes of 90, 300, and 600 s. SUVmax and SUVmean were calculated from liver and mediastinal blood pool, in addition to SUVmax from residual lymphomas and measures of noise. Results: SUVmax in liver and in mediastinal blood pool decreased significantly with increasing acquisition time, whereas SUVmean remained stable. In residual tumor, SUVmax was stable during different acquisition times. As a result, the DS was subject to change in three patients. Conclusions: Attention should be drawn towards the eventual impact of improvements in image quality on visual scoring systems such as the DS. Full article

(This article belongs to the Special Issue Technical and Clinical Applications on Long-Axial-Field-of-View/Total Body PET-CT)

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Open AccessCase Report

Long Axial Field-of-View PET for Ultra-Low-Dose Imaging of Non-Hodgkin Lymphoma during Pregnancy

Joyce van Sluis

Mar Bellido

Andor W. J. M. Glaudemans

and

Riemer H. J. A. Slart

Diagnostics 2023, 13(1), 28; https://doi.org/10.3390/diagnostics13010028 - 22 Dec 2022

Cited by 2 | Viewed by 1379

Abstract

Generally, positron emission tomography imaging is not often performed in the case of pregnant patients. The careful weighing of the risks of radiation exposure to the fetus and benefits for cancer staging and the swift onset of treatment for the mother complicates decision making in clinical practice. In oncology, the most commonly used PET radiotracer is 2-deoxy-2-[fluorine-18] fluoro-D-glucose (¹⁸F-FDG), a glucose analog which has established roles in the daily routines for, among other applications, initial diagnosis, staging, (radiation) therapy planning, and response monitoring. The introduction of long axial Field-of-View (LAFOV) PET systems allows for PET imaging with a reduced level of injected ¹⁸F-FDG activity while maintaining the image quality. Here, we discuss the first reported case of a pregnant patient diagnosed with follicular lymphoma using LAFOV PET imaging for the staging and therapy selection. The acquired PET images show diagnostic quality images with clearly distinguishable areas of lymphadenopathy, even with only 34 MBq of injected ¹⁸F-FDG activity, leading to a considerable decrease in the level of radiation exposure to the fetus. Full article

(This article belongs to the Special Issue Technical and Clinical Applications on Long-Axial-Field-of-View/Total Body PET-CT)

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Open AccessCase Report

A Case of Clinical Uncertainty Solved: Giant Cell Arteritis with Polymyalgia Rheumatica Swiftly Diagnosed with Long Axial Field of View PET

Pieter H. Nienhuis

Joyce van Sluis

Johannes H. van Snick

Andor W. J. M. Glaudemans

Sofie Meijering

Elisabeth Brouwer

and

Riemer H. J. A. Slart

Diagnostics 2022, 12(11), 2694; https://doi.org/10.3390/diagnostics12112694 - 04 Nov 2022

Cited by 2 | Viewed by 886

Abstract

The clinical presentation of giant cell arteritis (GCA) is often nonspecific. Differentiating GCA from infectious, malignant, or other autoimmune pathology based on signs, symptoms, and laboratory parameters may therefore be difficult. Fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging is an established tool in the diagnostic workup of GCA. An advantage of ¹⁸F-FDG-PET/CT is its ability to assist in the differential diagnosis by being able to demonstrate infection, inflammation, and malignancy when used in conjunction with clinical and laboratory data. Downsides to the use of ¹⁸F-FDG-PET/CT include its relatively low spatial resolution, associated radiation exposure, and the relatively long duration of imaging, causing limited availability and patient inconvenience. The advent of long axial field-of-view (LAFOV) PET/CT systems allows for PET imaging at a reduced imaging time or reduced tracer dose while maintaining high image quality. Here, we provide the first reported case of a patient with GCA and polymyalgia rheumatica (PMR) diagnosed using LAFOV PET/CT imaging. The patient presented in this case report had already been experiencing nonspecific symptoms for several years for which no cause was found. Lab investigations showed increased inflammatory parameters as well as persistent anemia. ¹⁸F-FDG LAFOV PET/CT attained high-quality images with clear signs of GCA and PMR even at 1 min of scan duration. Full article

(This article belongs to the Special Issue Technical and Clinical Applications on Long-Axial-Field-of-View/Total Body PET-CT)

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