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Technical and Clinical Applications of Long-Axial-Field-of-View/Total Body PET-CT, 2nd Edition
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Technical and Clinical Applications of Long-Axial-Field-of-View/Total Body PET-CT, 2nd Edition

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1334

Special Issue Editors

Prof. Dr. Riemer H.J.A. Slart

E-Mail Website
Guest Editor
Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: cardiovascular diseases; PET/CT; SPECT/CT; (hybrid) imaging; multimodality imaging
Special Issues, Collections and Topics in MDPI journals
Dr. Joyce van Sluis

E-Mail Website
Guest Editor
Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: nuclear medicine and molecular imaging; biomedical technology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Andor W.J.M. Glaudemans

E-Mail Website
Guest Editor
Medical Imaging Center, Department of Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
Interests: infections; inflammatory diseases; PET/CT; imaging; (tumor)immunology; multimodality imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

PET is widely considered the most sensitive technique available for noninvasively studying physiology, metabolism, and molecular pathways in living human beings. The introduction of total-body (TB)- and long-axial-field-of-view (LAFOV) PET/CT instruments has recently initiated a new and exciting era in medical imaging. Two developments offer the potential to dramatically increase the effective sensitivity of PET. First, by increasing the geometric coverage to encompass the entire body and increasing the sensitivity by a factor up to 40 times for total-body imaging. TB/LAFOV PET/CT will allow for accurate assessment of the extent of disease, particularly including the entire axial and appendicular skeleton. Quantitative global disease assessment provided by this new PET/CT approach will be superior to conventional measurements, which do not reflect overall disease activity. TB/LAFOV PET/CT imaging may have a revolutionary impact on the day-to-day practice of medicine and may become the leading imaging modality in the future. This Special Issue aims to present the role of TB/LAFOV PET/CT in the diagnosis and imaged-based therapeutic management of different (non)oncological diseases, large vessel vasculitis, and also with a focus on the technical background and developments in the era of TB/LAFOV PET/CT camera systems and quantification methodology. We encourage authors to submit both technical and clinical studies in this field. Clinical studies may include systematic reviews/meta-analysis, original retrospective studies, and prospective studies.

Prof. Dr. Riemer H.J.A. Slart
Dr. Joyce van Sluis
Prof. Dr. Andor W.J.M. Glaudemans
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • total body PET/CT
  • LAFOV PET/CT
  • technical
  • clinical
  • tracers

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Published Papers (1 paper)

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Research

13 pages, 5489 KiB  
Article
CT-Free Attenuation Correction in Paediatric Long Axial Field-of-View Positron Emission Tomography Using Synthetic CT from Emission Data
by Maria Elkjær Montgomery, Flemming Littrup Andersen, René Mathiasen, Lise Borgwardt, Kim Francis Andersen and Claes Nøhr Ladefoged
Diagnostics 2024, 14(24), 2788; https://doi.org/10.3390/diagnostics14242788 - 12 Dec 2024
Cited by 1 | Viewed by 999
Abstract
Background/Objectives: Paediatric PET/CT imaging is crucial in oncology but poses significant radiation risks due to children’s higher radiosensitivity and longer post-exposure life expectancy. This study aims to minimize radiation exposure by generating synthetic CT (sCT) images from emission PET data, eliminating the [...] Read more.
Background/Objectives: Paediatric PET/CT imaging is crucial in oncology but poses significant radiation risks due to children’s higher radiosensitivity and longer post-exposure life expectancy. This study aims to minimize radiation exposure by generating synthetic CT (sCT) images from emission PET data, eliminating the need for attenuation correction (AC) CT scans in paediatric patients. Methods: We utilized a cohort of 128 paediatric patients, resulting in 195 paired PET and CT images. Data were acquired using Siemens Biograph Vision 600 and Long Axial Field-of-View (LAFOV) Siemens Vision Quadra PET/CT scanners. A 3D parameter transferred conditional GAN (PT-cGAN) architecture, pre-trained on adult data, was adapted and trained on the paediatric cohort. The model’s performance was evaluated qualitatively by a nuclear medicine specialist and quantitatively by comparing sCT-derived PET (sPET) with standard PET images. Results: The model demonstrated high qualitative and quantitative performance. Visual inspection showed no significant (19/23) or minor clinically insignificant (4/23) differences in image quality between PET and sPET. Quantitative analysis revealed a mean SUV relative difference of −2.6 ± 5.8% across organs, with a high agreement in lesion overlap (Dice coefficient of 0.92 ± 0.08). The model also performed robustly in low-count settings, maintaining performance with reduced acquisition times. Conclusions: The proposed method effectively reduces radiation exposure in paediatric PET/CT imaging by eliminating the need for AC CT scans. It maintains high diagnostic accuracy and minimises motion-induced artifacts, making it a valuable alternative for clinical application. Further testing in clinical settings is warranted to confirm these findings and enhance patient safety. Full article
(This article belongs to the Special Issue Technical and Clinical Applications of Long-Axial-Field-of-View/Total Body PET-CT, 2nd Edition)
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