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Dentistry Journal
Special Issues
Bone Regeneration and Tissue Reconstruction in Dentistry
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Bone Regeneration and Tissue Reconstruction in Dentistry

A special issue of Dentistry Journal (ISSN 2304-6767).

Deadline for manuscript submissions: 31 May 2026 | Viewed by 12464

Special Issue Editor

Dr. Juho Suojanen

E-Mail Website
Guest Editor
1. Päijät-Häme Joint Authority for Health and Wellbeing, Department of Oral and Maxillofacial Surgery, Central Hospital, 15850 Lahti, Finland
2. Clinicum, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland
3. Cleft Palate and Craniofacial Center, Department of Plastic Surgery, HUS Helsinki University Hospital and University of Helsinki, 00029 Helsinki, Finland
Interests: maxillo-facial surgery; orthognathic surgery; virtual surgical planning; deformity surgery; CAD-CAM; patient-specific implants; medical modeling; facial trauma

Special Issue Information

Dear Colleagues,

Oral and maxillo-facial deformities, trauma, and various diseases can lead to impaired function and facial aesthetics. Long-lasting and functional reconstructions of facial structures often require a multidisciplinary approach and, sometimes, various operations with a focus on both bone and soft tissue reconstruction. Virtual surgical planning and medical modeling assistance through collaborations among all specialties in the field of dentistry represent everyday practice in most offices. Additionally, the development of bone and soft tissue substitutes and alloplastic materials, as well as surgical techniques, are rendering the reconstruction toolkit more and more versatile. However, a proper understanding of the basics of tissue reconstruction, deformity surgery, and a combination of surgical, periodontal, and prosthodontic techniques is essential and should be based on scientific background knowledge.

We welcome submissions of papers addressing the topics listed above for this Special Issue, including in vitro and animal models, clinical studies, epidemiological surveys, clinical trials, reviews, and meta-analyses. The Special Issue will focus on novel technigues such as additive manufacturing. It will also feature reports on novel materials and novel imaging and modeling techniques.

Dr. Juho Suojanen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone grafting
  • bone substitutes
  • soft tissue regeneration
  • orthognathic surgery
  • virtual surgical planning
  • deformity surgery
  • CAD-CAM structures
  • patient-specific implants
  • additive manufacturing
  • implantology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (5 papers)

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11 pages, 1617 KB  
Article
A 10-Year Follow-Up Study on the Success Rate of Maxillary Sinus Floor Augmentation and Implant Placement in Relation to Strontium Ranelate
by Eliza Dragan, Mihaela Ghinea, Danisia Haba and Gabriel Melian
Dent. J. 2025, 13(12), 565; https://doi.org/10.3390/dj13120565 - 1 Dec 2025
Viewed by 506
Abstract
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a dual-acting bone agent, stimulates osteoblasts while inhibiting osteoclasts, potentially improving bone density [...] Read more.
Background: Maxillary sinus floor augmentation (MSFA) is frequently required for implant placement in the atrophic posterior maxilla. However, limited bone quality and volume can compromise long-term success. Strontium ranelate (SrR), a dual-acting bone agent, stimulates osteoblasts while inhibiting osteoclasts, potentially improving bone density and osseointegration in grafted sites. Objective: This 10-year preliminary split-mouth study evaluated the long-term effects of SrR on bone density, volume, and implant success following MSFA. Methods: Six patients underwent bilateral MSFA using a lateral window approach. One side received systemic SrR (2 g/day for 6 months) after grafting, while the contralateral side served as a control. CBCT and DEXA analyses were performed to assess bone density and volume. Bone biopsies were examined histologically and by microindentation. Data were analyzed using paired t-tests or Wilcoxon signed-rank tests, depending on distribution, with significance at p < 0.05. Results: After 10 years, SrR-treated sites demonstrated a mean 22.9% increase in bone density versus 12.5% in untreated controls. Although both groups experienced minor reductions in bone volume (SrR: −13.3%; control: −12.8%), SrR samples exhibited greater mineralization, hardness, and lamellar bone maturity. Conclusions: SrR improved bone density and mechanical properties but not long-term volume preservation. Given the small sample size (n = 6) and absence of implant stability and patient-reported outcomes, these results should be interpreted with caution. Future large-scale clinical trials incorporating survival, ISQ, and quality-of-life data are warranted. Full article
(This article belongs to the Special Issue Bone Regeneration and Tissue Reconstruction in Dentistry)
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11 pages, 228 KB  
Article
Comparison of Postoperative Complications and Reoperation Rates of Le Fort I Osteotomies Using Demineralized Bone Matrix (DBM) or Autogenous Bone Grafts in Patients with Orofacial Clefts and Craniofacial Malformations
by Noémi Sipos, Junnu Leikola, Arja Heliövaara, Eeva Kormi and Juho Suojanen
Dent. J. 2025, 13(6), 256; https://doi.org/10.3390/dj13060256 - 9 Jun 2025
Viewed by 1940
Abstract
Background: This study aims to evaluate surgical outcomes and compares the prevalence and severity of postoperative complications and reoperations with maxillary osteotomies, focusing on the effectiveness of fixation with demineralized bone matrix (DBM) versus autogenous bone grafts (ABG) in patients with orofacial clefts [...] Read more.
Background: This study aims to evaluate surgical outcomes and compares the prevalence and severity of postoperative complications and reoperations with maxillary osteotomies, focusing on the effectiveness of fixation with demineralized bone matrix (DBM) versus autogenous bone grafts (ABG) in patients with orofacial clefts and craniofacial malformations. Methods: This retrospective cohort study included 138 consecutive patients treated at the Cleft Palate and Craniofacial Center, Helsinki University Hospital, from 2014 to 2022. The cohort consisted of patients with clefts (n = 113), craniosynostosis, and craniofacial syndromes (n = 25). The DBM group (n = 103) received DBX® (Musculoskeletal Transplant Foundation, Edison, NJ, USA), while the ABG group (n = 35) received autogenous bone grafts. Surgical procedures included Le Fort I and bimaxillary osteotomies. Complications involving the maxilla or both jaws were included in the analysis. Both major and minor complications, as well as reoperations, were analyzed and compared. Results: The DBM group had 13.6% of patients with complications, while the ABG group had 20.0%. Reoperation rates were 6.8% for the DBM group and 5.7% for the ABG group. There were no statistically significant differences in complication or reoperation rates between the DBM and ABG groups. Conclusions: The findings suggest that using DBM or ABG in maxillary osteotomies does not significantly affect complication or reoperation rates, supporting DBM as a viable alternative for maxillary surgeries. Full article
(This article belongs to the Special Issue Bone Regeneration and Tissue Reconstruction in Dentistry)
13 pages, 3200 KB  
Article
Socket Sealing Using Free Gingival Grafts: A Randomized Controlled Trial
by Ralitsa Yotsova
Dent. J. 2025, 13(1), 24; https://doi.org/10.3390/dj13010024 - 7 Jan 2025
Cited by 4 | Viewed by 2583
Abstract
Background: Post-extraction ridge resorption is an inevitable phenomenon that cannot be eliminated but is significantly reduced using additional surgical techniques known as socket preservation. They aim to create favorable conditions for implant placement and prosthetic restoration. This study aims to assess the effect [...] Read more.
Background: Post-extraction ridge resorption is an inevitable phenomenon that cannot be eliminated but is significantly reduced using additional surgical techniques known as socket preservation. They aim to create favorable conditions for implant placement and prosthetic restoration. This study aims to assess the effect of socket sealing (SS) with free gingival grafts on the vertical resorption of socket walls at the premolar and molar regions over 3 months. Methods: This randomized two-arm controlled trial with parallel groups (1:1 allocation) was conducted at the Department of Oral Surgery, Medical University-Varna, Bulgaria, from 27 June 2022 to 20 April 2023. Forty patients aged 30–65 were equally and randomly allocated to the SS or the control groups. Atraumatic tooth extraction was performed. In the control group, the socket was left on secondary wound healing. In the SS group, the socket orifice was “sealed” with an FGG harvested from the hard palate or maxillary tuberosity. Results: Data analysis demonstrated that SS with an FGG is a successful method for reducing the post-extraction resorption of the socket walls. In addition, this study confirms that the thickness of the buccal wall is a significant factor in its vertical resorption. Conclusions: Socket sealing with an FGG is a valuable method that eliminates the need for flap reflection and compensates for the soft tissue deficit when immediate implant placement or bone augmentation is required. Further research is necessary to determine the role of different factors influencing bone resorption and compare the effect of different socket preservation methods. Full article
(This article belongs to the Special Issue Bone Regeneration and Tissue Reconstruction in Dentistry)
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20 pages, 13330 KB  
Case Report
Long-Term Clinical Outcome of a Surgically Treated Ameloblastoma: Over a Decade of Follow-Up and Oral Rehabilitation
by Ruxandra Elena Luca, Ciprian Ioan Roi, Alexandra Roi and Eduard Gîdea-Paraschivescu
Dent. J. 2026, 14(1), 39; https://doi.org/10.3390/dj14010039 - 7 Jan 2026
Viewed by 373
Abstract
Background: Ameloblastomas account for roughly 1% of all jaw tumours and cysts, typically manifesting as slow-growing, painless swellings that expand both buccal and lingual cortical plates and may infiltrate adjacent soft tissue, often leading to a delayed diagnosis. These benign tumours, characterized [...] Read more.
Background: Ameloblastomas account for roughly 1% of all jaw tumours and cysts, typically manifesting as slow-growing, painless swellings that expand both buccal and lingual cortical plates and may infiltrate adjacent soft tissue, often leading to a delayed diagnosis. These benign tumours, characterized by local invasiveness, originate from epithelial tissues and may develop from dental lamina cell rests, the enamel apparatus, the epithelial lining of odontogenic cysts, or basal epithelial cells of the oral mucosa. Methods: This paper aims to describe the comprehensive and interdisciplinary management of an extensive ameloblastoma in a 16-year-old patient, emphasizing the diagnostic challenges, surgical resection, reconstructive procedures, and subsequent oral rehabilitation. Results: At the eleven-year follow-up, clinical and radiographic examinations showed no signs of tumour recurrence. The patient presented no symptoms, indicating neither pain nor functional impairment. The prosthetic rehabilitation utilizing implant-supported fixed restorations was successfully completed, resulting in satisfactory masticatory function and aesthetics. This case adds to the existing evidence on the management of extensive ameloblastomas by demonstrating successful long-term outcomes following interdisciplinary surgical reconstruction and rehabilitation. Conclusions: The presented case highlights the complexity of restoring the lost tissues and functions, as well as the long-term clinical, functional, and aesthetic outcomes over an eleven-years follow-up period. Full article
(This article belongs to the Special Issue Bone Regeneration and Tissue Reconstruction in Dentistry)
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13 pages, 1522 KB  
Systematic Review
Hyaluronic Acid in Bone Regeneration: Systematic Review and Meta-Analysis
by Claudia Lorenzi, Andrea Leggeri, Ilaria Cammarota, Paolo Carosi, Vincenzo Mazzetti and Claudio Arcuri
Dent. J. 2024, 12(8), 263; https://doi.org/10.3390/dj12080263 - 19 Aug 2024
Cited by 21 | Viewed by 6176
Abstract
Aim: The aim of this systematic review and meta-analysis was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when hyaluronic acid (HA) was added and mixed with graft materials in bone regeneration. Materials and methods: This review [...] Read more.
Aim: The aim of this systematic review and meta-analysis was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when hyaluronic acid (HA) was added and mixed with graft materials in bone regeneration. Materials and methods: This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) of the National Institute of Health Research (registration number CRD42024530030). Electronic research was performed, and involved studies published up to 29 February 2024 using a specific word combination. The primary outcome was to assess possible histomorphometric differences in new bone formation and in remaining graft particles when HA was added and mixed with graft materials in bone regeneration. The search resulted in 138 potential studies. Meta-analyses were performed using the fixed and random effects model to identify significant changes in new bone formation and in the remaining graft particles. Results: After screening procedures, only three randomized controlled trials fulfilled the inclusion criteria and were selected for qualitative and quantitative analysis. The effect size of HA in the new bone formation was not statistically significant at 95% CI (Z = 1.734, p-value = 0.083, 95 % CI -,399; 6516). The effect size of HA in the remaining graft particles was not statistically significant at 95% CI (Z = −1.042, p-value = 0.297, CI -,835; 255). Conclusions: Within the limitations of the present systematic review and meta-analysis, the addition of HA to bone graft did not result in significant changes in bone regeneration procedures in terms of new bone formation and residues, even if the included studies showed encouraging and promising results. Full article
(This article belongs to the Special Issue Bone Regeneration and Tissue Reconstruction in Dentistry)
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